Anowara Begum

Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome

OBJECTIVE To compare the effectiveness of letrozole and clomiphene citrate (CC) in induction of ovulation in polycystic ovary syndrome (PCOS). DESIGN Prospective, randomized, not blinded, controlled trial. SETTING A tertiary level infertility care center. PATIENT(S) Sixty-four anovulatory patients with PCOS, who failed to ovulate when taking 100 mg/day CC in previous cycles. INTERVENTION(S) Patients were randomly divided into two groups by lottery and treated with either 7.5 mg/day letrozole (an aromatase inhibitor) or 150 mg/day CC for 5 days starting from day 3 of the menstrual cycle. MAIN OUTCOME MEASURE(S) Occurrence of ovulation, endometrial thickness, and pregnancy rate (PR). RESULT(S) Twenty (62.5%) patients from the letrozole group and 12 (37.50%) patients from the CC group ovulated during the observation period. Mean serum E2 level was 817.75 pg/mL and 448.03 pg/mL in the CC and letrozole groups, respectively, on the day of hCG administration. The mean endometrial thickness on the day of hCG administration was 9.03 mm and 10.37 mm in the CC and letrozole groups, respectively. The mean D21 serum P was 13.09 ng/mL and 19.09 ng/mL in the CC and letrozole groups, respectively. Thirteen patients from the letrozole group (40.63%) and six patients from the CC group (18.75%) became pregnant. CONCLUSION(S) Letrozole has better ovulation and PR in comparison to CC in patients with PCOS.

Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome.

Aim:  The aim of the present study was to assess whether continuation of metformin therapy throughout pregnancy can reduce the development of gestational diabetes in women with polycystic ovarian syndrome (PCOS).

A low dose ("Dhaka") magnesium sulphate regime for eclampsia.

Background. Eclampsia remains a common cause of maternal death in Bangladesh. Early experience of magnesium sulphate use for eclampsia in Bangladesh was based on a lower dose regime, tailored for use in the smaller woman.

Reducing maternal mortality from eclampsia, using magnesium sulphate

Since the introduction of low dose magnesium sulphate to treat eclamptic patients at Dhaka Medical College, mortality rates have fallen from 16% to 8%. Personal communications from other centres in Bangladesh show similar findings.

Loading dose versus standard regime of magnesium sulfate in the management of eclampsia: A randomized trial

To determine whether only loading dose of magnesium sulfate is effective in controlling convulsion in eclampsia.

Role of aromatase inhibitor in ovulation induction in patients with poor response to clomiphene citrate

Aim:  To examine the efficacy of aromatase inhibitor in the induction of ovulation.