Anthony L. Komaroff

Effect of the

The apolipoprotein Ee4 (APOEe4) allele increases vulnerability to Alzheimers disease, but its role in cognitive decline other than dementia has been

An Update on the Obesity Problem

We have all heard the statistics: 30% of U.S. adults are obese, and another 35% are overweight; 15% of children and adolescents weigh too much, and

Selective and Nonselective NSAIDs Are Associated with Excess Cardiovascular Risk

The cardiovascular risks of selective cyclooxygenase (COX)-2–blocking nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized (JW Gen Med Feb

Pandemic Influenza A (H1N1) Virus (“Swine Flu”) Probably Is More Virulent Than Seasonal Flu Virus

A Japanese team has examined whether pandemic influenza A (H1N1) virus is more virulent than a widely circulating seasonal H1N1 human flu virus. The

Interleukin-4 Therapy Improves Psoriasis

Psoriasis is an autoimmune disease that, like rheumatoid arthritis and Crohns disease, is characterized by activity of interferon-γ-producing T helper

“Leaky Gut” Is Real and Might Contribute to Disease

The tight cell–cell junctions in the gut epithelium control the passage of water, various molecules, cells, and organisms from the gut lumen into the

Aggressive Gene Sequencing Can Reveal Causes of Some Previously Undiagnosed Diseases

The cost of sequencing the human genome and of measuring large numbers of metabolites in a single blood sample (known as metabolomics) has plummeted.

Gut Microbiome Affects Salt-Sensitive Hypertension in Mice and Humans

Salt-sensitive hypertension is caused, at least in part, by expansion of intravascular volume due to a high-salt diet. In a new study, researchers

New Evidence That Bacteria Might Be a Cause of Colon Cancer

In 2011, investigators reported that Fusobacteria often were found in colon cancer tissue (NEJM JW Gen Med Dec 1 2011 and Genome Res 2012; 22:292).

Gut Microbiome Might Affect Effectiveness and Adverse Effects of Immune Checkpoint–Inhibitor Therapy

Immune checkpoint–inhibitor (ICI) therapy has proved to be remarkably effective for certain cancers (NEJM JW Gen Med Jun 16 2015; [e-pub] and Nature