Anthony N. Galanos

Nutrition and Function: Is There a Relationship Between Body Mass Index and the Functional Capabilities of Community-Dwelling Elderly?

Objective: To determine if there is a relationship between body mass index and the ability to perform the usual activities of living in a sample of community‐dwelling elderly.

Patients who want their family and physician to make resuscitation decisions for them : Observations from SUPPORT and HELP

OBJECTIVE: To determine the extent to which older or seriously ill inpatients would prefer to have their family and physician make resuscitation decisions for them rather than having their own stated preferences followed if they were unable to decide themselves.

Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients

OBJECTIVE To determine if body mass Index (BMI = weight [kg]/height [m]2), predictive of mortality in longitudinal epidemiologic studies, was also predictive of mortality in a sample of seriously ill hospitalized subjects. DESIGN Prospective, multicenter study. SETTING Five tertiary care medical centers in the United States. PATIENTS Patients > or = 18 yrs of age who had one of nine illnesses of sufficient severity to anticipate a 6-month mortality rate of 50% were enrolled at five participating sites in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT). INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Patients were asked their current height and weight as part of the demographic data. Stratifying body mass index by percentile rank (< or = 15, 15 to 85, and > or = 85th percentiles), risk ratios for mortality were calculated by Cox Proportional Hazards using the 15th to 85th percentile of body mass index as the reference group while controlling for multiple variables such as prior weight loss, albumin, and Acute Physiology Score. A body mass index in the < or = 15th percentile was associated with an excess risk of mortality (risk ratio = 1.23; p < .001) within 6 months. High body mass index (> or = 85th percentile) was not significantly related to risk of mortality. CONCLUSIONS Body mass index, a simple anthropometric measure of nutrition employed in community epidemiologic studies, has now been demonstrated to be a predictor of mortality in an acutely ill population of adults at five different tertiary centers. Even when controlling for multiple disease states and physiologic variables and removing from the analysis all patients with significant prior weight loss, a body mass index below the 15th percentile remained a significant and independent predictor of mortality. Examination of patient vs. proxy data did not change the results. Future studies examining variables predictive of mortality should include body mass index, even in acutely ill populations with a poor probability of survival.

Predicting functional status outcomes in hospitalized patients aged 80 years and older

OBJECTIVE: To develop a model estimating the probability of a patient aged 80 years or older having functional limitations 2 months and 12 months after being hospitalized.

Age-related differences in care preferences, treatment decisions, and clinical outcomes of seriously ill hospitalized adults: lessons from SUPPORT.

OBJECTIVES: To review previously published findings about how patient age influenced patterns of care for seriously ill patients enrolled in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT).

Prediction of Survival for Older Hospitalized Patients: The HELP Survival Model

OBJECTIVE: To develop and validate a model estimating the survival time of hospitalized persons aged 80 years and older.

Impact of Depressive Symptoms on Hospitalization Risk in Community‐Dwelling Older Persons

OBJECTIVE: To determine whether depressive symptoms in older adults are associated with an increased risk for hospitalization.

Ethnic Differences in the Place of Death of Elderly Hospice Enrollees

Elderly minorities are more likely to die in inpatient settings than their Caucasian counterparts. It is not known whether this difference is due to cultural preferences for place of death or decreased access to hospice. This analysis examines ethnic differences in the place of death of elderly hospice patients.

Sociodemographic Correlates of Health Beliefs among Black and White Community Dwelling Elderly Individuals.

This study examined the hypothesis that sociodemographic characteristics such as age, education, race, and gender would be predictive of Multidimensional Health Locus of Control Subscale scores in a population-based sample of 342 community dwelling elderly individuals. Bivariate analysis revealed associations between black race, lower socioeconomic status, and lower education on the Chance and Powerful Others Subscales. While the multivariate analysis revealed no predictors for the Internal Subscale, a higher socioeconomic status, white race, and a higher level of education continued to predict low scores on the Chance Subscale when controlling for all other variables. Scores on the Powerful Others Subscale appeared to be a function of socioeconomic status and gender. Of note, the higher the education level for both men and women, the lower the scores on the Chance and Powerful Others Subscales. This sex by education interaction term reached statistical significance for the Chance Subscale. The results demonstrate the measurable influence of sociodemographic variables on the health beliefs of community dwelling elderly individuals.

The comprehensive assessment of community dwelling elderly: Why functional status is not enough

The present study attempts to determine empirically the relationship of measures of functional status to other domains common to geriatric assessment, and to ascertain whether functional status can substitute for other domains of clinical assessment. A comprehensive research survey was administered in the home to a randomly selected population of 4163 community residents aged 65 and over in the Duke EPESE, one of the four sites of the National Institute on Aging- funded Established Populations for Epidemiologic Studies of the Elderly. Sample members were predominantly black (55%), female (65%), between 65 and 74 years of age (61%), and lived in five contiguous counties within the state of North Carolina. Measurements included three measures of functional status ranging from basic activities of daily living (ADL) to strenuous mobility items, and summary measures of cognition, depression, and overall physical health. The three functional status measures were inter- correlated. However, with the exception of cognitive status and performance of instrumental ADL, the functional status measures failed to show a clinically significant relationship with the domains of cognition, depression, or overall physical health status. Furthermore, even among those sample members impaired in all three domains, 8% could still perform strenuous activities, and over 50% could still perform the basic activities of daily living. The data show that functional status measures are not necessarily indicative of an elder’s mental or physical health. Each domain of assessment contributes unique data, and no one area can fully substitute for another. (Aging Clin. Exp. Res. 6: 343–352, 1994)