Antonia Kolokythas

Vascular Malformations and Their Treatment in the Growing Patient

Vascular anomalies consisting of 2 groups of lesions, vascular tumors and vascular malformations, frequently arise in the head and neck and often occur in the pediatric age group. This classification is based on the differences in natural history, histologic features, and cellular turnover of the 2 groups. The management of these anomalies can be challenging, and evidence-based decisions about treatment are complicated by an inconsistency in the nomenclature for these lesions found in the literature. This article covers the clinical presentation, etiology, and pathophysiology and treatment approaches of the vascular anomalies in the pediatric population.

Bone Margin Analysis for Benign Odontogenic Tumors

With the potential exception of the case of ameloblastoma, information relevant to the exact tumor-bone interface and extent of bone invasion by the commonly encountered odontogenic tumors is lacking. These tumors are rare. Treatment rendered varies significantly. Although commonly accepted practices are recommended, scientific evidence is relatively lacking. Prospective multicenter studies from tertiary treatment centers are required for evidence-based guidelines. Until studies are available, the proposed linear bone resection margin for odontogenic tumors and the evaluation of its adequacy in tumor eradication will be based on the limited data available.

Selective serotonin reuptake inhibitors and dental implant failure—A significant concern in elders?

OBJECTIVE Depression is a significantly prevalent health concern in geriatric populations. Selective serotonin reuptake inhibitor drugs (SSRI) are the most commonly prescribed antidepressant agents, with increasing rates of prescription. The present report aimed to present a concise review of the current understanding regarding SSRI effects on bone and dental implant outcomes. MATERIALS AND METHODS A broad-based review and summary of literature pertaining to the effects of SSRI on bone metabolism and on dental implant survival was performed. RESULTS The available literature indicates that serotonin plays a significant role in bone metabolism and experimental reports demonstrate adverse impacts of SSRI on multiple pathways of bone metabolism. Early clinical reports suggest detrimental effects of SSRI on dental implant survival. The type of SSRI drug, dosage and host-related genetic and metabolic factors could be potential modulating factors. There is a paucity of data regarding SSRI usage and dental implant survival specific to geriatric cohorts. CONCLUSION As older individuals comprise a high-risk group for both high oral rehabilitation and SSRI use, clinicians should be aware the potential association between SSRI and dental implant failures. Well-designed investigations specific to geriatric cohorts are essential to understand the implications of SSRI use on dental implant prognosis.