Antonio Barragán
Hospital Universitario de Canarias
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Featured researches published by Antonio Barragán.
Journal of the American College of Cardiology | 2003
Domingo Hernández; Alejandro de la Rosa; Antonio Barragán; Ysamar Barrios; Eduardo Salido; Armando Torres; B. Martin; Ignacio Laynez; Amelia Duque; Antonia María de Vera; V. Lorenzo; Antonio González
OBJECTIVES We studied the impact of the angiotensin-converting enzyme (ACE)/DD genotype on morphologic and functional cardiac changes in adult endurance athletes. BACKGROUND Trained athletes usually develop adaptive left ventricular hypertrophy (LVH), and ACE gene polymorphisms may regulate myocardial growth. However, little is known about the impact of the ACE/DD genotype and D allele dose on the cardiac changes in adult endurance athletes. METHODS; Echocardiographic studies (including tissue Doppler) were performed in 61 male endurance athletes ranging in age from 25 to 40 years, with a similar period of training (15.6 +/- 4 h/week for 12.6 +/- 5.7 years). The ACE genotype (insertion [I] or deletion [D] alleles) was ascertained by polymerase chain reaction (DD = 27, ID = 31, and II = 3). Athletes with the DD genotype were compared with their ID counterparts. RESULTS The DD genotype was associated with a higher left ventricular mass index (LVMI) than the ID genotype (162.6 +/- 36.5 g/m(2) vs. 141.6 +/- 34 g/m(2), p = 0.031), regardless of other confounder variables. As a result, 70.4% of DD athletes and only 42% of ID athletes met the criteria for LVH (p = 0.037). Although systolic and early diastolic myocardial velocities were similar in DD and ID subjects, a more prolonged E-wave deceleration time (DT) was observed in DD as compared with ID athletes, after adjusting for other biologic variables (210 +/- 48 ms vs. 174 +/- 36 ms, respectively; p = 0.008). Finally, a positive association between DT and myocardial systolic peak velocity (medial and lateral peak S(m)) was only observed in DD athletes (p = 0.013, r = 0.481). CONCLUSIONS The ACE/DD genotype is associated with the extent of exercise-induced LVH in endurance athletes, regardless of other known biologic factors.
Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques | 2012
Juan Lacalzada; Alejandro de la Rosa; J Jimenez; Rubén Juárez; Antonio Barragán; Gabriela Blanco; J Iribarren; Juan Alfonso Bonilla M.D.; Ignacio Laynez
Purpose: To determine whether echocardiographic calcium index (ECI) calculated using transthoracic echocardiography (TTE) predicts coronary ischemic events. We also wished to determine coronary artery calcium score (CACS), the presence of obstructive coronary artery disease (CAD) and plaque composition, all of which were assessed by multidetector computed tomography (MDCT). Methods: We carried out a prospective cohort study of 82 consecutive outpatients with chest pain and low‐moderate risk of CAD, referred for noninvasive coronariography by MDCT. ECI was blindly assessed by TTE and correlated with subsequent cardiovascular events during a follow up period of 36 months. Results: ECI values of ≥7 had a sensitivity of 77.3%, a specificity of 90%, positive predictive value of 73.9%, and negative predictive value of 91.5% with respect to future coronary ischemic events. In addition, patients with ECI ≥ 7 showed a greater presence of severe calcified and obstructive CAD and a linear increase of obstructed vessels and mixed and calcified plaques, with a linear trend according to ECI values. Conclusion: ECI values of ≥7 determine poor CAD prognosis in relation to ischemic events. Furthermore, ECI ≥ 7 may serve as a marker of content of coronary artery calcium, intraluminal obstruction, and plaque composition. Therefore, ECI seems to provide prognostic information as well as information about the characteristics of the plaque of atheroma.
Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques | 2016
Juan Lacalzada; J Jimenez; José Luis Iribarren; Alejandro de la Rosa; Marta Martín-Cabeza; María Manuela Izquierdo; Belén Marí-López; Martín J. García-González; Pablo Jorge-Pérez; Antonio Barragán; Ignacio Laynez
Postoperative atrial fibrillation (POAF) is frequent after cardiac surgery. We aimed to establish a predictive model of POAF based on postoperative transthoracic echocardiography (TTE) findings.
Revista Espanola De Cardiologia | 2009
J Iribarren; J Jimenez; Antonio Barragán; M Brouard; Juan Lacalzada; Leonardo Lorente; R Perez; Lorena Raja; Rafael Martínez; M Mora; Ignacio Laynez
INTRODUCTION AND OBJECTIVES Postoperative atrial fibrillation is a common complication of carrying out cardiac surgery with extracorporeal circulation (ECC). The aim of this study was to determine whether preoperative left atrial contractile dysfunction, as assessed by tissue Doppler echocardiography, is associated with the development of postoperative new-onset atrial fibrillation (PAF). METHODS Transthoracic Doppler echocardiography was performed preoperatively in patients undergoing elective cardiac surgery. Left atrial contractile function was evaluated by tissue Doppler imaging (TDI) of the mitral annulus. RESULTS The study included 92 patients in sinus rhythm preoperatively who underwent elective cardiac surgery with ECC: 73 (79%) were male and 19 (21%) were female, and their mean age was 67 (10) years. Of these, 19 (20.6%) developed PAF 34 (12) h postoperatively. Bivariate analysis showed that PAF was associated with older age (71 [7] years vs 66 [10] years; P=.034), a large left atrial diameter (LAD), and a low peak atrial systolic mitral annular velocity (A velocity) and a high mitral E/A ratio on TDI. Logistic regression analysis showed that PAF was independently associated with a large LAD (odds ratio [OR] =2.23; 95% confidence interval [CI], 1.05-4.76; P=.033) and a low A velocity (OR=0.70; 95% CI, 0.55-0.99; P=.034). CONCLUSIONS Preoperative left atrial dysfunction, as assessed by TDI, was associated with an increased risk of PAF.
Annals of Noninvasive Electrocardiology | 2000
Antonio Barragán; Alberto Domingez; Francisco Marrero; Martin Garcia; Juan Iacalzada; Antonio Lara; Manuel Moreno de Castro; Vicente Gonzalez; Francisco Bosa; Ignacio Laynez; Diego De Armas
Background: Patency of the infarct‐related artery is known to be a powerful determinant of the prognosis after AMI. Most studies have reported a lower incidence of late potentials from patients treated with thrombolytic agents than patients not so treated. The purpose of this study was to evaluate the use of ventricular late potentials in the first week after AM1 to differentiate patients according to the TIMI flow in the infarct‐related artery.
Archive | 2011
Juan Lacalzada; Amelia Duque; Alejandro de la Rosa; Antonio Barragán; María Manuela Izquierdo; Eduardo Arroyo; Ana Laynez; Ignacio Laynez
The normal cardiac cycle consists of two phases, systole and diastole, which are repeated over time to maintain an adequate cardiac output. The systole has been traditionally regarded as the main capital phase, leaving at diastole as a secondary process and almost forgotten. However, today we know that diastole is a crucial stage in the functioning of the heart. Its dysfunction can lead even in cases with preserved systolic function in heart failure. About half of patients with new diagnoses of heart failure have normal or near normal global ejection fractions. These patients are diagnosed with “diastolic heart failure” or “heart failure with preserved ejection fraction” (Zipes et al., 2011).
Kidney International | 2000
Domingo Hernández; Juan Lacalzada; Eduardo Salido; José Linares; Antonio Barragán; V. Lorenzo; Luz Higueras; B. Martin; Aurelio Rodríguez; Ignacio Laynez; José Manuel González-Posada; Armando Torres
Kidney International | 1997
Domingo Hernández; Juan Lacalzada; Margarita Rufino; Armando Torres; Natalia Martín; Antonio Barragán; Ysamar Barrios; Manuel Macía; Eduardo de Bonis; V. Lorenzo; Aurelio Rodríguez; José Manuel González-Posada; Eduardo Salido
Nephrology Dialysis Transplantation | 2007
Domingo Hernández; Ana Pilar Gonzalez; Margarita Rufino; Ignacio Laynez; Alejandro de la Rosa; Esteban Porrini; Juan Lacalzada; Antonio Barragán; V. Lorenzo; Armando Torres
International Journal of Cardiovascular Imaging | 2015
Juan Lacalzada; Alejandro de la Rosa; María Manuela Izquierdo; J Jimenez; J Iribarren; Martín J. García-González; Belén Marí López; María Amelia Duque; Antonio Barragán; Celestino Hernández; María Carrillo-Pérez; Ignacio Laynez