Antonio D’Andrilli

The Role of Lymphadenectomy in Lung Cancer Surgery

Adequate lymphadenectomy represents a fundamental procedure in lung cancer surgery for accurate staging and potential survival benefit. Various techniques are used in current surgical practice for the intraoperative lymph node removal associated with pulmonary resection, without definitive indications concerning the preferable option. Different studies in the last decades have compared complete mediastinal lymph node dissection with lymph node sampling regarding their effect on long-term survival, recurrence rate, accuracy of pathologic staging, and surgical morbidity. Literature data and technical aspects of lymph node dissection are reported and discussed in this article.

Extensive Resections: Pancoast Tumors, Chest Wall Resections, En Bloc Vascular Resections

Infiltration by lung tumor of adjacent anatomic structures including major vessels, main bronchi, and chest wall not only influences the oncologic severity of the disease but also increases the technical complexity of surgery, requiring extended resections and demanding reconstructive procedures. Completeness of resection represents in every case one of the main factors influencing the long-term outcome of patients. Technical and oncologic aspects of extended operations, including resection of Pancoast tumors and chest wall, bronchovascular sleeve resections, and en bloc resections of major thoracic vessels, are reported in this article.

Bronchial and Arterial Sleeve Resection After Induction Therapy for Lung Cancer

Lobectomy with reconstruction of the bronchus and pulmonary artery is a viable therapeutic option for patients with centrally located non-small cell lung cancer. Preoperative chemotherapy or chemoradiotherapy may represent an additional risk factor for postoperative complications because of increased difficulty in surgical dissection and potential impairment of bronchial healing. Although limited data are available in the literature in this setting, a few published studies have reported the possibility of performing even complex bronchovascular reconstructions after neoadjuvant treatment with no increased morbidity and mortality. This article discusses the main technical details and data from the literature.

Primary malignant tumour of the lung with neuroendocrine and melanoma differentiation.

Melanocytic differentiation has been described in rare cases of melanin-containing neuroendocrine tumours of the lung [1–5], thyroid [6] and thymus [7]. In some of the cases, neuroendocrine granules and melanosomes were lying free in the cytoplasm of tumour cells, thus indicating true coexpression of melanocytic and neuroendocrine differentiation. On the other hand, neuroendocrine differentiation, consisting in the presence of neuroendocrine granules at ultrastructural level and of intense immunostaining for chromogranin-A and synaptophysin, was described in three cases of cutaneous and mucosal malignant melanomas [8]. Divergent differentiation towards unrelated embryological tissue has been reported in malignant melanoma [9]. So far, cases of neuroendocrine carcinoma with associated melanomatous component in the lung have not been described. There is growing evidence that tumour development may derive from neoplastic transformation of adult stem cells [10]. In a recent publication, it was reported that in the human skin there is a SOX2-positive stem cell capable of differentiation along the neuroendocrine or melanocytic lines [11]. In the present report, we describe the first case of a malignant neoplasm of the lung showing unambiguous differentiation towards neuroendocrine carcinoma and malignant melanoma.

A Novel Technique for Laryngotracheal Reconstruction for Idiopathic Subglottic Stenosis

Idiopathic subglottic stenosis is the most challenging condition in the field of upper airway reconstruction. We describe a successful novel technique for enlarging the airway space at the site of the laryngotracheal anastomosis in very high-level reconstructions.

Reconstruction of the bronchus and pulmonary artery.

Bronchovascular reconstructive procedures employed in order to avoid pneumonectomy (PN) in patients functionally unsuitable have provided, over time, excellent results, similar or even better than those obtained by PN. In recent years, new successful techniques have been developed that pertain in particular the prevention of major complications and the reconstruction of the pulmonary artery (PA). Encouraging data from increasing number of published experiences support the choice of parenchymal sparing procedures for lung cancer also in patients with good functional reserve. This is even more true if considering trials published in the last 10 years, thus indicating that improved outcome can be achieved with increased experience in reconstructive techniques and perioperative management. This article discusses the main technical aspects and results of literature.

Long term compensatory sweating results after sympathectomy for palmar and axillary hyperhidrosis.

BACKGROUND Endoscopic thoracic sympathectomy is currently the best treatment for primary upper extremity hyperhidrosis, but the potential for adverse effects, particularly the development of compensatory sweating, is a concern and often precludes surgery as a definitive therapy. This study aims to evaluate long-term results of two-stage unilateral versus one-stage bilateral thoracoscopic sympathectomy. METHODS From November 1995 to February 2011, 261 patients with severe palmar and/or axillary hyperhidrosis underwent endoscopic sympathectomy with a follow-up of at least 4 years. One-hundred and twenty-six patients received one-stage bilateral, single port video-assisted thoracoscopic sympathectomy (one-stage group) and 135 patients underwent two-stage unilateral, single-port video-assisted thoracoscopic sympathectomy, with a mean time interval of four months between the procedures (two-stage group). RESULTS The mean postoperative follow-up period was 7.2 years (range, 4-9 years). Sixteen patients (12.7%) in the one-stage group and 15 patients (11.1%) in the two-stage group suffered from bradycardia (P=0.15). Recurrences occurred in three patients (2.4%) in the one-stage group and one (0.7%) in the two-stage group (P=0,09). Facial flushing or hyperthermia occurred in eight patients (6.3%) in the one-stage group and 11 (8.1%) of the two-stage group. Compensatory sweating occurred in 27 patients (21.4%) in the one-stage group and six patients (4.4%) in the two-stage group (P=0.0001). However, compensatory sweating recovered in five patients (83.3%) in the two-stage group versus nine (33.35%) in one-stage group during the follow-up period (Log-rank test P=0.016; HR, 7.196; 95% CI, 1.431-36.20). An improvement in postoperative quality of life (QoL) scores was observed in at least 90% of patients at three years after surgery in the one-stage group and at least 95% of patients in the two-stage group (P=0.001). CONCLUSIONS Compensatory sweating seems to improve during the follow-up period with a higher recovery rate after two-stage unilateral versus one-stage bilateral sympathectomy for patients with palmar and axillary hyperhidrosis.

Does a Multimodal No-Compression Suture Technique of the Intercostal Space Reduce Chronic Postthoracotomy Pain? A Prospective Randomized Study

Introduction: Chronic postthoracotomy pain is a significant adverse outcome of thoracic surgery. We evaluated with a prospective randomized trial the effect of a multimodal no‐compression suture technique of the intercostal space on postoperative pain occurrence in patients undergoing minithoracotomy. Methods: Patients undergoing a muscle‐sparing lateral minithoracotomy for different thoracic diseases were randomly divided into two groups: 146 patients received intercostal muscle flap harvesting and pericostal no‐compression “edge” suture (the IMF group), and 151 patients received a standard suture technique associated with an intrapleural intercostal nerve block (the IINB group). Pain scores and interference of pain with daily activities were assessed by using the Italian version of the Brief Pain Inventory on day 1, and at 1 to 6 months postoperatively. The results of pulmonary function tests (spirometry and the 6‐minute walking test) were evaluated preoperatively and at 1 and 6 months postoperatively. Results: Postthoracotomy pain scores throughout the first postoperative day were significantly lower in the IMF group. After 1 and 6 months, patients in the IMF group had a significantly lower average pain score (p = 0.001). There were no significant differences in pain interference scores at each evaluation time point in either group. However, differences were shown in lung function test results at 1 and 6 months postoperatively (the forced expiratory volume in 1 second in the IINB group averaged 68.8 ± 17.4% of predicted value and 72.8 ± 10.5%, respectively, and in the IMF group it averaged 83.1 ± 7.4% and 86.4 ± 12.8%, respectively [p = 0.023 and 0.013, respectively]; the 6‐minute walking test results in the IINB group averaged 311.1 ± 51.0 and 329.9 ± 54.8 m, respectively, and those in the IMF group averaged 371.2 ± 54.8 and 395.7 ± 56.4 m, respectively [p = 0.0001]). Conclusions: The multimodal no‐compression suture technique is a rapid and feasible procedure that reduces the intensity of early and chronic postthoracotomy pain.

Use of Sealants to Reduce Air Leak Duration and Hospital Stay After Lung Resection

Parenchymal air leak is the most common complication after lung resection. It occurs in 48%1 to 70%2 of patients in large series. Prolonged parenchymal air leaks persisting over 7 days have been reported to have an incidence of 15–18%.3–5 The risk of prolonged air leak increases when interlobar fissures are incomplete, and in patients with emphysematous lung. Furthermore, the presence of poor predicted postoperative forced expiratory volume during the first second, pleural adhesions and upper lobe resections have been found to be predictors of prolonged air leaks in large retrospective studies.3 Persisting air leaks have a detrimental effect on the postoperative course resulting in a longer need for chest tube drainage, with associated pain, reduced mobility and increased risk of further complications.6 This is associated with prolonged hospital stay and higher costs of care, with the need for additional inpatient and outpatient resources.7

Superior Vena Cava Replacement for Thymic Malignancies

BACKGROUND Advanced-stage thymic tumors infiltrating the superior vena cava (SVC), when radically resectable, can be surgically treated by SVC prosthetic replacement within a multimodality therapeutic approach. We hereby present our series of patients undergoing SVC resection and prosthetic reconstruction for stage III or IV thymic malignancies. METHODS Between 1989 and 2015, 27 patients with thymic tumors (21 thymoma, 6 thymic carcinoma) infiltrating the SVC underwent radical resection with a SVC prosthetic replacement by a bovine pericardial conduit in 12 cases, a polytetrafluoroethylene conduit in 13, a porcine pericardial conduit in 1, and a saphenous vein conduit in 1. All the patients underwent vascular conduit reconstruction by the cross-clamping technique. RESULTS Six patients were myasthenic. All resections were complete (R0). Twelve patients received induction treatment. Pulmonary resection was associated in 16 patients (11 wedge, 5 pneumonectomy). Twenty-two patients were Masaoka stage III and 5 were stage IVa. Mortality rate was 7.4%; no mortality was related to the vascular reconstruction. Major complication rate was 11.1%. At a median follow-up of 58 (range, 4 to 134) months, recurrence occurred in 9 (36%) patients. Three- and 5-year overall survival rates were 80% and 58.1%, respectively. Three-and 5-year cancer-specific survival were 90.5% and 75.4%. Cancer-specific survival rates of thymoma patients at 5 years were 93.8%. Five-year cancer-specific survival of all stage III patients was 77.1%. Thymic carcinoma histology was a negative prognostic factor. Long-term patency of the pericardial conduits was 100%. CONCLUSIONS En bloc resection and conduit reconstruction of the SVC is a good option to allow radical resection of locally advanced thymic tumors. A heterologous pericardial conduit represents the favorite option in our experience.