Antonio Longo

Determination of absolute configuration of the derivative from 2-[4-(1-oxo-2-isoindolinyl)-phenyl]-propionic acid and R-(+)-1-phenylethylamine by 1H-NMR spectroscopy; use of shift reagent with diastereoisomeric amides

The assignment of the S-(+), R-(−) absolute configuration of Indoprofene, an analgesic and anti-inflammatory drug, has been made via an NMR configurational correlation of diastereoisomeric phenylethylamides with the aid of Eu(fod)3.

4-tetrahydropyranthioazetidinyl phosphoranes: Versatile intermediates in the synthesis of 2-penems

Abstract The total synthesis of four racemic trans -6-ethyl-2-penems has been developed using the 4-tetrahydropyranthioazetidinyl phosphorane 10 as a common precursor.

“4,7-lactams”, intermediates for penems synthesis. II. Total synthesis of (+)-2,2-dimethyl-9-oxo-3-oxa-6-thia-1-azabicyclo [5.2.01,7]nonane

Abstract The total synthesis of chiral “4,7-lactam” 4 has been accomplished starting from 4-acetoxyazetidinone. An independent route from methyl penicillanate has been used to test the efficiency of the foregoing synthesis.

“4,7-lactams”, intermediates for penems synthesis. I. skeletal conversion of penicillanic acid to (+)-2,2,5,5-tetramethyl-9-oxo-3-oxa-6-thia-azabicyclo[5,2,01,7]nonane

Abstract The synthesis of chiral “4,7-lactam“ 5 has been accomplished starting from natural 6-aminopenicillanic acid.