Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Antonio M. Mendes is active.

Publication


Featured researches published by Antonio M. Mendes.


Pharmacy Practice (internet) | 2016

Medication reconciliation at patient admission: a randomized controlled trial

Antonio M. Mendes; Natália Fracaro Lombardi; Vânia S Andrzejevski; Gibran Avelino Frandoloso; Cassyano Januário Correr; Mauricio Carvalho

Objective: To measure length of hospital stay (LHS) in patients receiving medication reconciliation. Secondary characteristics included analysis of number of preadmission medications, medications prescribed at admission, number of discrepancies, and pharmacists interventions done and accepted by the attending physician. Methods: A 6 month, randomized, controlled trial conducted at a public teaching hospital in southern Brazil. Patients admitted to general wards were randomized to receive usual care or medication reconciliation, performed within the first 72 hours of hospital admission. Results: The randomization process assigned 68 patients to UC and 65 to MR. LHS was 10±15 days in usual care and 9±16 days in medication reconciliation (p=0.620). The total number of discrepancies was 327 in the medication reconciliation group, comprising 52.6% of unintentional discrepancies. Physicians accepted approximately 75.0% of the interventions. Conclusion: These results highlight weakness at patient transition care levels in a public teaching hospital. LHS, the primary outcome, should be further investigated in larger studies. Medication reconciliation was well accepted by physicians and it is a useful tool to find and correct discrepancies, minimizing the risk of adverse drug events and improving patient safety.


Revista Latino-americana De Enfermagem | 2016

Analysis of the discrepancies identified during medication reconciliation on patient admission in cardiology units: a descriptive study

Natália Fracaro Lombardi; Antonio M. Mendes; Rosa Camila Lucchetta; Wálleri Christini Torelli Reis; Maria Luiza Drechsel Fávero; Cassyano Januário Correr

Objetivos: este estudo observacional teve como objetivo descrever discrepâncias encontradas na realizacao de conciliacao medicamentosa de pacientes admitidos em unidades de cardiologia de um hospital de grande porte. Metodos: a historia de medicacao dos pacientes foi coletada dentro de 48h apos a admissao, e as discrepâncias, identificadas como intencionais ou nao intencionais, foram classificadas como de: omissao, duplicidade, dose, frequencia, intervalo e via. Resultados: a maioria dos pacientes incluidos pertencia ao sexo feminino (58,0%), com idade media de 59 anos, e com indice de comorbidades de Charlson entre 1 e 3 (75,5% dos casos). Das 117 discrepâncias encontradas, 50,4% foram nao intencionais. Dessas, 61,0% foram de omissao, 18,6% de dose, 18,6% de intervalo e 1,7% de via de administracao. Conclusao: o estudo mostra a alta prevalencia de discrepâncias, principalmente de omissao, sendo quase metade nao intencionais. Esse dado remete ao numero de medicamentos que nao sao reincorporados ao tratamento dos pacientes, podendo repercutir em consequencias clinicas importantes.ABSTRACT Objectives: this observational study aimed to describe the discrepancies identified during medication reconciliation on patient admission to cardiology units in a large hospital. Methods: the medication history of patients was collected within 48 hours after admission, and intentional and unintentional discrepancies were classified as omission, duplication, dose, frequency, timing, and route of drug administration. Results: most of the patients evaluated were women (58.0%) with a mean age of 59 years, and 75.5% of the patients had a Charlson comorbidity index score between 1 and 3. Of the 117 discrepancies found, 50.4% were unintentional. Of these, 61.0% involved omission, 18.6% involved dosage, 18.6% involved timing, and 1.7% involved the route of drug administration. Conclusion: this study revealed a high prevalence of discrepancies, most of which were related to omissions, and 50% were unintentional. These results reveal the number of drugs that are not reincorporated into the treatment of patients, which can have important clinical consequences.


PLOS ONE | 2018

Mapping the characteristics of network meta-analyses on drug therapy: A systematic review

Fernanda S. Tonin; Lm Steimbach; Antonio M. Mendes; Hh Borba; Roberto Pontarolo; Fernando Fernandez-Llimos

Background Network meta-analysis (NMA) is a new tool developed to overcome some limitations of pairwise meta-analyses. NMAs provide evidence on more than two comparators simultaneously. This study aimed to map the characteristics of the published NMAs on drug therapy comparisons. Methods A systematic review of NMAs comparing pharmacological interventions was performed. Searches in Medline (PubMed) and Scopus along with manual searches were conducted. The main characteristics of NMAs were systematically collected: publication metadata, criteria for drug inclusion, statistical methods used, and elements reported. A methodological quality score with 25 key elements was created and applied to the included NMAs. To identify potential trends, the median of the publication year distribution was used as a cut-off. Results The study identified 365 NMAs published from 2003 to 2016 in more than 30 countries. Randomised controlled trials were the primary source of data, with only 5% including observational studies, and 230 NMAs used a placebo as a comparator. Less than 15% of NMAs were registered in PROSPERO or a similar system. One third of studies followed PRISMA and less than 9% Cochrane recommendations. Around 30% presented full-search strategies of the systematic review, and 146 NMAs stated the selection criteria for drug inclusion. Over 75% of NMAs presented network plots, but only half described their geometry. Statistical parameters (model fit, inconsistency, convergence) were properly reported by one third of NMAs. Although 216 studies exhibited supplemental material, no data set of primary studies was available. The methodological quality score (mean 13·9; SD 3·8) presented a slightly positive trend over the years. Conclusion The map of the published NMAs emphasises the potential of this tool to gather evidence in healthcare, but it also identified some weaknesses, especially in the report, which limits its transparency and reproducibility.


Journal of Evaluation in Clinical Practice | 2018

Pharmacist-led discharge medication counselling: A scoping review

Aline F. Bonetti; Wálleri C. Reis; Natália Fracaro Lombardi; Antonio M. Mendes; Harli Pasquini Netto; Inajara Rotta; Fernando Fernandez-Llimos; Roberto Pontarolo

RATIONALE, AIMS, AND OBJECTIVES Discharge medication counselling has produced improved quality of care and health outcomes, especially by reducing medication errors and readmission rates, and improving medication adherence. However, no studies have assembled an evidence-based discharge counselling process for clinical pharmacists. Thus, the present study aims to map the components of the pharmacist-led discharge medication counselling process. METHODS We performed a scoping review by searching electronic databases (Pubmed, Scopus, and DOAJ) and conducting a manual search to identify studies published up to July 2017. Studies that addressed pharmacist-led discharge medication counselling, regardless of the population, clinical conditions, and outcomes evaluated, were included. RESULTS A total of 1563 studies were retrieved, with 75 matching the inclusion criteria. Thirty-two different components were identified, and the most prevalent were the indication of the medications and adverse drug reactions, which were reported in more than 50% of the studies. The components were reported similarly by studies from the USA and the rest of the world, and over the years. However, 2 differences were identified: the use of a dosage schedule, which was more frequent in studies published in 2011 or before and in studies outside the USA; and the teach-back technique, which was used more frequently in the USA. Poor quality reporting was also observed, especially regarding the duration of the counselling, the number of patients, and the medical condition. CONCLUSION Mapping the components of the pharmacist-led discharge counselling studies through a scoping review allowed us to reveal how this service is performed around the world. Wide variability in this process and poor reporting were identified. Future studies are needed to define the core outcome set of this clinical pharmacy service to allow the generation of robust evidence and reproducibility in clinical practice.


International Journal of Epidemiology | 2018

Methodological quality assessment of network meta-analysis of drug interventions: implications from a systematic review

Fernanda S. Tonin; Hh Borba; Letícia Paula Leonart; Antonio M. Mendes; Lm Steimbach; Roberto Pontarolo; Fernando Fernandez-Llimos

Background We aimed to determine the methodological quality of network meta-analyses (NMAs) and their compliance with reporting guidelines. Methods A systematic review of NMAs comparing any pharmacological interventions was performed (searches in Medline and Scopus). The characteristics of NMAs were collected by two independent reviewers. We applied R-AMSTAR to all NMAs, generating a methodological quality score that could range from 11 to 44 points. PRISMA and PRISMA-NMA reporting checklists were converted into quantitative scores (maximum values of 27 and 32 points). To normalize the values between these two checklists, a third score (PRISMA-SCORE) of 0-1 was created. The correlation of the scores with NMA publication year, journal impact factor and most productive countries were calculated using non-parametric tests. Results We identified 477 NMAs. Only 36.1% of studies reported having followed PRISMA statements. The medians of R-AMSTAR, PRISMA and PRISMA-NMA scores were 28 (IQR 25-31), 21 (IQR 19-23) and 23 (IQR 19-26), respectively. Several problems were noted in NMAs (e.g. lack of study protocol, issues in literature searches, lack of raw data). NMAs from the most productive countries (USA and China) have similar methodological quality. Correlation analyses between R-AMSTAR and normalized PRISMA-SCORE revealed a strong positive correlation (Spearmans ρ = 0.776; P <0.001). A weak but positive correlation was found for PRISMA-SCORE and journal impact factor (0.193; P <0.001). Conclusions The important growth of NMA publication rate during the past 5 years is not associated with better methodological and reporting quality. Editors, peer reviewers, researchers and funding agencies should ensure that methodological and reporting standards are met before publication.


Diabetology & Metabolic Syndrome | 2018

Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials

Maria Eugenia Balbi; Fernanda S. Tonin; Antonio M. Mendes; Hh Borba; Astrid Wiens; Fernando Fernandez-Llimos; Roberto Pontarolo

BackgroundVitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients.MethodsWe performed a systematic review with meta-analyses. Electronic searches were conducted in PubMed, Scopus, and Web of Science (December 2017). Randomized controlled trials evaluating the effect of any vitamin or vitamin complex supplementation on antioxidant status as primary outcome were included. The outcomes considered were: reduction of malondialdehyde (MDA); augmentation of glutathione peroxidase (GPx); changes in total antioxidant capacity (TAC), enhance in superoxide dismutase enzyme—SOD, and thiobarbituric acid reactive substances (TBARS). Outcomes of glycemic control were also evaluated. Pairwise meta-analyses were performed using software Review Manager 5.3.ResultsThirty trials fulfilled the inclusion criteria, but only 12 could be included in the meta-analyses of antioxidant outcomes. The most commonly studied vitamins were B, C, D and E. Vitamin E was related to significant reduction of blood glucose as well as glycated hemoglobin compared to placebo, while both vitamins C and E were mainly associated with reducing MDA and TBARS and elevating GPx, SOD and TAC, compared to placebo. However, outcome reports in this field are still inconsistent (e.g. because of a lack of standard measures).ConclusionsSupplementation of vitamin E may be a valuable strategy for controlling diabetes complications and enhancing antioxidant capacity. The effects of other micronutrients should be further investigated in larger and well-designed trials to properly place these complementary therapies in clinical practice.


Clinics | 2018

Impact of discharge medication counseling in the cardiology unit of a tertiary hospital in Brazil: A randomized controlled trial

Aline F. Bonetti; Bruna Q. Bagatim; Antonio M. Mendes; Inajara Rotta; Renata Cristiane dos Reis; Maria Luiza Drechsel Fávero; Fernando Fernandez-Llimos; Roberto Pontarolo

OBJECTIVES: This study aimed to evaluate the impact of pharmacist-provided discharge counseling on mortality rate, hospital readmissions, emergency department visits, and medication adherence at 30 days post discharge. METHODS: This randomized controlled trial was approved by the local ethics committee and included patients aged 18 years or older admitted to the cardiology ward of a Brazilian tertiary hospital. The intervention group received a pharmacist-led medication counseling session at discharge and a telephone follow-up three and 15 days after discharge. The outcomes included the number of deaths, hospital readmissions, emergency department visits, and medication adherence. All outcomes were evaluated during a pharmacist-led ambulatory consultation performed 30 days after discharge. RESULTS: Of 133 patients, 104 were included in the analysis (51 and 53 in the intervention and control groups, respectively). The intervention group had a lower overall readmission rate, number of emergency department visits, and mortality rate, but the differences were not statistically significant (p>0.05). However, the intervention group had a significantly lower readmission rate related to heart disease (0% vs. 11.3%, p=0.027), despite the small sample size. Furthermore, medication counseling contributed significantly to improved medication adherence according to three different tools (p<0.05). CONCLUSIONS: Pharmacist-provided discharge medication counseling resulted in better medication adherence scores and a lower incidence of cardiovascular-associated hospital readmissions, thus representing a useful service for cardiology patients.


Revista Latino-americana De Enfermagem | 2016

Análise das discrepâncias encontradas durante a conciliação medicamentosa na admissão de pacientes em unidades de cardiologia: um estudo descritivo

Natália Fracaro Lombardi; Antonio M. Mendes; Rosa Camila Lucchetta; Wálleri Christini Torelli Reis; Maria Luiza Drechsel Fávero; Cassyano Januário Correr

Objetivos: este estudo observacional teve como objetivo descrever discrepâncias encontradas na realizacao de conciliacao medicamentosa de pacientes admitidos em unidades de cardiologia de um hospital de grande porte. Metodos: a historia de medicacao dos pacientes foi coletada dentro de 48h apos a admissao, e as discrepâncias, identificadas como intencionais ou nao intencionais, foram classificadas como de: omissao, duplicidade, dose, frequencia, intervalo e via. Resultados: a maioria dos pacientes incluidos pertencia ao sexo feminino (58,0%), com idade media de 59 anos, e com indice de comorbidades de Charlson entre 1 e 3 (75,5% dos casos). Das 117 discrepâncias encontradas, 50,4% foram nao intencionais. Dessas, 61,0% foram de omissao, 18,6% de dose, 18,6% de intervalo e 1,7% de via de administracao. Conclusao: o estudo mostra a alta prevalencia de discrepâncias, principalmente de omissao, sendo quase metade nao intencionais. Esse dado remete ao numero de medicamentos que nao sao reincorporados ao tratamento dos pacientes, podendo repercutir em consequencias clinicas importantes.ABSTRACT Objectives: this observational study aimed to describe the discrepancies identified during medication reconciliation on patient admission to cardiology units in a large hospital. Methods: the medication history of patients was collected within 48 hours after admission, and intentional and unintentional discrepancies were classified as omission, duplication, dose, frequency, timing, and route of drug administration. Results: most of the patients evaluated were women (58.0%) with a mean age of 59 years, and 75.5% of the patients had a Charlson comorbidity index score between 1 and 3. Of the 117 discrepancies found, 50.4% were unintentional. Of these, 61.0% involved omission, 18.6% involved dosage, 18.6% involved timing, and 1.7% involved the route of drug administration. Conclusion: this study revealed a high prevalence of discrepancies, most of which were related to omissions, and 50% were unintentional. These results reveal the number of drugs that are not reincorporated into the treatment of patients, which can have important clinical consequences.


Revista Latino-americana De Enfermagem | 2016

Análisis de las discrepancias encontradas durante la conciliación medicamentosa en la admisión de pacientes en unidades de cardiología: un estudio descriptivo

Natália Fracaro Lombardi; Antonio M. Mendes; Rosa Camila Lucchetta; Wálleri Christini Torelli Reis; Maria Luiza Drechsel Fávero; Cassyano Januário Correr

Objetivos: este estudo observacional teve como objetivo descrever discrepâncias encontradas na realizacao de conciliacao medicamentosa de pacientes admitidos em unidades de cardiologia de um hospital de grande porte. Metodos: a historia de medicacao dos pacientes foi coletada dentro de 48h apos a admissao, e as discrepâncias, identificadas como intencionais ou nao intencionais, foram classificadas como de: omissao, duplicidade, dose, frequencia, intervalo e via. Resultados: a maioria dos pacientes incluidos pertencia ao sexo feminino (58,0%), com idade media de 59 anos, e com indice de comorbidades de Charlson entre 1 e 3 (75,5% dos casos). Das 117 discrepâncias encontradas, 50,4% foram nao intencionais. Dessas, 61,0% foram de omissao, 18,6% de dose, 18,6% de intervalo e 1,7% de via de administracao. Conclusao: o estudo mostra a alta prevalencia de discrepâncias, principalmente de omissao, sendo quase metade nao intencionais. Esse dado remete ao numero de medicamentos que nao sao reincorporados ao tratamento dos pacientes, podendo repercutir em consequencias clinicas importantes.ABSTRACT Objectives: this observational study aimed to describe the discrepancies identified during medication reconciliation on patient admission to cardiology units in a large hospital. Methods: the medication history of patients was collected within 48 hours after admission, and intentional and unintentional discrepancies were classified as omission, duplication, dose, frequency, timing, and route of drug administration. Results: most of the patients evaluated were women (58.0%) with a mean age of 59 years, and 75.5% of the patients had a Charlson comorbidity index score between 1 and 3. Of the 117 discrepancies found, 50.4% were unintentional. Of these, 61.0% involved omission, 18.6% involved dosage, 18.6% involved timing, and 1.7% involved the route of drug administration. Conclusion: this study revealed a high prevalence of discrepancies, most of which were related to omissions, and 50% were unintentional. These results reveal the number of drugs that are not reincorporated into the treatment of patients, which can have important clinical consequences.


Pharmacy Practice (granada) | 2017

Network meta-analysis: a technique to gather evidence from direct and indirect comparisons

Fernanda S. Tonin; Inajara Rotta; Antonio M. Mendes; Roberto Pontarolo

Collaboration


Dive into the Antonio M. Mendes's collaboration.

Top Co-Authors

Avatar

Roberto Pontarolo

Federal University of Paraná

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Fernanda S. Tonin

Federal University of Paraná

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Hh Borba

Federal University of Paraná

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Inajara Rotta

Federal University of Paraná

View shared research outputs
Top Co-Authors

Avatar

Lm Steimbach

Federal University of Paraná

View shared research outputs
Top Co-Authors

Avatar

Rosa Camila Lucchetta

Federal University of Paraná

View shared research outputs
Researchain Logo
Decentralizing Knowledge