Antonio Rottino

Aneurysm of the abdominal aorta, with rupture into the duodenum

Abstract 1. 1. Thirty-one cases of rupture of an abdominal aneurysm into the stomach and duodenum were collected from the literature. 2. 2. The clinical and pathologic data on these cases are presented in table form. 3. 3. Four cases of what was probably mycotic aneurysm were collected from the literature and are described. 4. 4. Another case of aneurysm which may have been mycotic is reported; in this instance the aneurysm ruptured into the duodenum.

Hodgkin's disease in pregnancy

Abstract Thirty-five cases of pregnancy associated with Hodgkins disease have been reviewed with regard to incidence, treatment, and prognosis. The literature has been briefly reviewed. Interruption of pregnancy is not indicated on the basis of evidence presented in our series. Pregnancy had no effect on the incidence of exacerbations nor did it adversely affect survival time.

Therapeutic action of muscle adenylic acid on ulcers and dermatitis associated with varicose or phlebitic veins; preliminary report.

While testing muscle adenylic acid to see whether it would relieve the extreme fatigue characteristic of Hodgkin’s disease it was unexpectedly discovered that it relieved pruritus instead. This occasioned a systematic study of the effect of adenylic acid on the pruritus stemming from causes other than Hodgkin’s disease, and the results proved sufficiently good to warrant publication of a preliminary report (3, 4). A second chance observation was made by one of the authors’ on a patient suffering from leukemia and persistent thrombophlebitis (see case 5). By the fourth day of adenylic acid administration it was noted with surprise that the phlebitis had almost completely subsided. This led to an extension of our study to patients with peripheral vascular disease. The results to date on patients with varicose veins and others with phlebitis have been so unexpectedly gratifying as to impel us again to submit a preliminary report, in the hope of spreading interest in the therapeutic effect of adenylic acid.2 Our case reports follow.

Cardiac involvement in Hodgkin's disease☆

Abstract A case of Hodgkins disease with massive involvement of heart and lungs is described. The literature is reviewed and a table made of cases showing the more usual nodular involvement of the pericardium. The conclusion reached is that the heart is a poor soil for the Hodgkins disease process.

Endocardial fibroelastosis occurring in the adult

Abstract A brief review of the concept of fibroelastosis is presented and a case in a young adult is reported similar to that seen in infants. This case probably represente an extremely rare case of a patient with this disease maintaining sufficient cardiac reserve to carry her into adult life.

Relief from pruritus following upon administration of adenylic acid.

Summary Thirty-six patients suffering from pruritus of diverse etiology were treated with adenylic acid. In thirty instances there was a subsidence of the pruritus ranging from complete to mild. So far we have been able to find in the rather extensive literature no reference to the beneficial effect of adenylic acid upon pruritus.

OUTLINE OF PROBLEMS IN HODCKIN'S DISEASE

Although interest in Hodgkin’s disease has always been great and tontributions to the literature on the subject voluminous, progress has been exceedingly slow and basic discoveries very few. Unfortunately we now know little more about the disease than was known fifty years ago. Research in Hodgkin’s disease, except for the early work in pathology and the discovery of the ameliorative effects of X rays and the mustard compounds, has been frustratingly sterile. The chief purpose of this monograph is to stimulate those engaged in fundamental research into finding application of their work to the problem of Hodgkin’s disease. 1 shall therefore emphasize a few of the many questions in need of resolution. First, there is the important one concerning the nature and cause of the disease; second, that relating to the function of the system primarily affected, namely, the lymphoreticuloendothelial system; and finally, that dealing with the function of the eosinophil. Also involved are questions that are fundamentally genetic and immunologic in nature. While I shall touch upon each of these questions here, they are considered in detail elsewhere in these pages. Some readers may not have any special interest in Hodgkin’s disease per se, even though working in some capacity with the system vitally affected by it. To reiterate, I hope their interest may become sufficiently engaged that, as they pursue their own particular studies aimed a t elucidating the enigma of the lymphocyte, histiocyte, or eosinophil, they will bear Hodgkin’s disease in mind and be alert to note anything applicable to its solution. Since I am a pathologist, it is logical and natural for me to begin with the histopathology of the disease. Although the pathologist has a very good grasp of the histological changes and the sequence of their occurrence in the natural progress of the disease, he needs the help of students in other fields to interpret their significance. The initial change consists in hyperplasia of the small lymphocyte without alteration of its anatomic features. Eosinophils also make an early appearance, but the reticuloendothelial cell is the one whose structure becomes altered drastically. At first only a few of them are visibly affected, and they are inconspicuous and may even be overlooked. The changes that the reticuloendothelial (RE) cell undergoes consist of an increase in total size and in the size of its nucleus, which may assume very bizarre forms. Visible alterations occur in the chromatin and nucleolus; the latter may become very large in size and may be seen as two or more round or irregular bodies. The cytoplasm of the cell may become unusually granular. Nothing comparable to this is seen to occur either in the lymphocyte or in the eosinophil. All this has led me to conclude (and this is not an original thought) that the target for

Carcinogenic action of refined tumor factor isolated from mouse leukemia tissue.

Summary 1) A procedure has been developed for extracting and refining tumor factor contained in mouse leukemic tissue. The refined preparation repeatedly induced a variety of neoplasms in high percentage of inoculated animals, but no leukemia was induced. 2) Results were reproducible and time of tumor appearance predictable. Tumors developed at earlier age than when crude cell-free filtrates are used. 3) This work suggests that an attempt be made to isolate tumor factor from Drosophila, fish lymphoma, chicken lymphoma, Lucké frog kidney tumor, etc., so that a tumor-inducing mechanism common to Metazoan life may be demonstrable. 4) By purification technic discussed, tumor factor has been isolated from Hodgkins disease tissue and other neoplastic tissues from human beings to be reported.

Demonstration that Red Blood Cell Slowing Factor Found in Cancer Serum by Microelectrophoresis is an α1 Component

Conclusion The red blood cells of persons with malignant neoplasm move more slowly in an electric field than do cells of persons in health. They do so because their surface electrical charge has been altered by a factor present in the blood serum, called for convenience the SF-89 factor. By paper electrophoresis it has been demonstrated that this factor is located in the α 1 protein fraction of the serum.

Erythrocyte microelectrophoretic slowing factors in pregnancy, chronic cervicitis, and neoplasia.

Abstract The electrophoretic mobility of the erythrocytes of healthy human beings is different from that of persons with certain diseases and of pregnant women. In some diseases factors capable of reducing the mobility of the red cell to low values are present in the serum of humans. The slowing factor in the serum of persons with nonneoplastic disease was shown to differ in four respects from that of patients with malignant neoplastic disease. It was found that erythrocytes and serum from a series of patients with nonneoplastic disease gave uniform results, as was also the case for a series of patients with malignant neoplasm. That serum and cells of the two groups possessed different properties was clearly demonstrable. Serum of patients with benign neoplasm did not contain a slowing factor.