António Sousa Pereira

Biological and Medical Data Analysis

Medical Databases and Information Systems.- Application of Three-Level Handprinted Documents Recognition in Medical Information Systems.- Data Management and Visualization Issues in a Fully Digital Echocardiography Laboratory.- A Framework Based on Web Services and Grid Technologies for Medical Image Registration.- Biomedical Image Processing Integration Through INBIOMED: A Web Services-Based Platform.- The Ontological Lens: Zooming in and out from Genomic to Clinical Level.- Data Analysis and Image Processing.- Dynamics of Vertebral Column Observed by Stereovision and Recurrent Neural Network Model.- Endocardial Tracking in Contrast Echocardiography Using Optical Flow.- Unfolding of Virtual Endoscopy Using Ray-Template.- Knowledge Discovery and Data Mining.- Integration of Genetic and Medical Information Through a Web Crawler System.- Vertical Integration of Bioinformatics Tools and Information Processing on Analysis Outcome.- A Grid Infrastructure for Text Mining of Full Text Articles and Creation of a Knowledge Base of Gene Relations.- Prediction of the Performance of Human Liver Cell Bioreactors by Donor Organ Data.- A Bioinformatic Approach to Epigenetic Susceptibility in Non-disjunctional Diseases.- Foreseeing Promising Bio-medical Findings for Effective Applications of Data Mining.- Statistical Methods and Tools for Biomedical Data Analysis.- Hybridizing Sparse Component Analysis with Genetic Algorithms for Blind Source Separation.- Hardware Approach to the Artificial Hand Control Algorithm Realization.- Improving the Therapeutic Performance of a Medical Bayesian Network Using Noisy Threshold Models.- SVM Detection of Premature Ectopic Excitations Based on Modified PCA.- Decision Support Systems.- A Text Corpora-Based Estimation of the Familiarity of Health Terminology.- On Sample Size and Classification Accuracy: A Performance Comparison.- Influenza Forecast: Comparison of Case-Based Reasoning and Statistical Methods.- Tumor Classification from Gene Expression Data: A Coding-Based Multiclass Learning Approach.- Boosted Decision Trees for Diagnosis Type of Hypertension.- Markov Chains Pattern Recognition Approach Applied to the Medical Diagnosis Tasks.- Computer-Aided Sequential Diagnosis Using Fuzzy Relations - Comparative Analysis of Methods.- Collaborative Systems in Biomedical Informatics.- Service Oriented Architecture for Biomedical Collaborative Research.- Simultaneous Scheduling of Replication and Computation for Bioinformatic Applications on the Grid.- The INFOBIOMED Network of Excellence: Developments for Facilitating Training and Mobility.- Bioinformatics: Computational Models.- Using Treemaps to Visualize Phylogenetic Trees.- An Ontological Approach to Represent Molecular Structure Information.- Focal Activity in Simulated LQT2 Models at Rapid Ventricular Pacing: Analysis of Cardiac Electrical Activity Using Grid-Based Computation.- Bioinformatics: Structural Analysis.- Extracting Molecular Diversity Between Populations Through Sequence Alignments.- Detection of Hydrophobic Clusters in Molecular Dynamics Protein Unfolding Simulations Using Association Rules.- Protein Secondary Structure Classifiers Fusion Using OWA.- Efficient Computation of Fitness Function by Pruning in Hydrophobic-Hydrophilic Model.- Evaluation of Fuzzy Measures in Profile Hidden Markov Models for Protein Sequences.- Bioinformatics: Microarray Data Analysis.- Relevance, Redundancy and Differential Prioritization in Feature Selection for Multiclass Gene Expression Data.- Gene Selection and Classification of Human Lymphoma from Microarray Data.- Microarray Data Analysis and Management in Colorectal Cancer.

Vital-Jacket ® : A wearable wireless vital signs monitor for patients' mobility in cardiology and sports

The Vital Jacket® (VJ) is a wearable vital signs monitoring system that joins textiles with microelectronics. After several years of development within the university lab, it has been licensed to a start-up company. Its evolutions have focused on cardiology and sports and scaled down from a jacket to a single T-shirt. The VJ manufacturing process has recently been certified to comply with the standards ISO9001 and ISO13485 and the cardiology version was approved as a Medical Device for the European market compliant with the MDD directive 42/93/CE, holding the CE1011 mark. The authors intend to wear VJs during the days of the congress to demonstrate its usefulness in first hand and will exemplify the different scenarios of use of this innovative wearable intelligent garment.

DiseaseCard: A Web-Based Tool for the Collaborative Integration of Genetic and Medical Information

The recent advances on genomics and proteomics research bring up a significant grow on the information that is publicly available. However, navigating through genetic and bioinformatics databases can be a too complex and unproductive task for a primary care physician. Moreover, considering the rare genetic diseases field, we verify that the knowledge about a specific disease is commonly disseminated over a small group of experts. The capture, maintenance and sharing of this knowledge over user-friendly interfaces will introduce new insights in the understanding of some rare genetic diseases. In this paper we present DiseaseCard, a web available collaborative service that aims to integrate and disseminate genetic and medical information on rare genetic diseases.

Ventilation and perfusion display in a single image

A new method of ventilation and perfusion display onto a single image is presented. From the data on regions of interest of the lungs, three-dimensional histograms are created, containing as parameters X and Y for the position of the pixels, Z for the perfusion and colour for local ventilation. The perfusion value is supplied by sets of curves having Z proportional to the local perfusion count rate. Ventilation modulates colour. Four perspective views of the histogram are simultaneously displayed to allow visualization of the entire organ. Information about the normal ranges for both ventilation and perfusion is also provided in the histograms.

A low cost ISDN based teleradiology system

This paper describes a Teleradiology system designed for standard AT compatible platforms, that uses ISDN, the Integrated Services Digital Network, services potential to mimic natural human communication between radiology experts. This system will be used in a demonstration unit to setup In mid 1992 within the Portuguese ISDN pilot phase.

3D registration and integrated visualization of multimodal clinical data

The authors present here a registration solution and a 3D integrated representation of the fused modalities, CT and SPECT. The registration process is based on the inertial moments determination. The visualization process uses a raycaster philosophy with multiple objects in volume. Functional data is represented with pseudo colour on orthogonal clipping planes, anatomical information is displayed using a raycaster approach with a grey shade look up table. The registration process is evaluated with a phantom derived from a genuine clinical volume. A case study is presented.<<ETX>>

Three different approaches in visualization of multimodal clinical data

Problems common to the visualization in multimodal clinical environments are presented. Three different solutions for the visualization of 3D multimodal clinical data are proposed, having in mind the constrains related to the interactivity goal. Some resulting images containing this type of data in an integrated form are presented.

A telematic based antenatal care demonstrator

This paper describes an experience carried out in Portugal in the area of antenatal care. A telematic based system is being implemented on a region of very high perinatal death rate enabling integration of services, remote access to expert advice and identification of high risk pregnancies. Considering the methodology used during early stages of the implementation, the system is an example of a general model of health care integration that may be used as a framework for other systems aiming at to integrate different levels of health care.

Integrated package for interactive analysis and interpretation of nuclear medicine images

This paper describes a software package based on a set of integrated tools intended to be used in nuclear medicine imaging environments. These tools, following a functionally consistent and open architecture, aim to provide an efficient and user-friendly way for handling the analysis and interpretation of nuclear medicine images in a broad range of applications. The Image, Graphics, and Colors tools are the basic building blocks. Besides basic image handling facilities, the Image tool was designed to accomplish both conventional and special purposed processing tasks. Among these, the interactive definition of organ shaped regions of interest, functional imaging (e.g., mean transit time images in ventilatory lung studies) and activity quantitation should be pointed out as the most intensively used facilities. The Graphics tool is used mainly to display and analyze the activity/time curves resulting from parametric related studies. As intensity color coding has gained wide acceptance in nuclear medicine it was thought convenient to implement a Colors tool intended to provide interactive intensity manipulation. The X Window graphics interface system is the basis for the implementation of this set of independent but intercommunicating tools which are intended to run on all UNIX workstations provided with, at least, an 8 bit depth frame buffer.