Anuja Gupta

Convective instability of a layer of a ferromagnetic fluid rotating about a vertical axis

Abstract Thermal instability in a layer of a ferromagnetic fluid rotating about a vertical axis and permeated by a vertical magnetic field is investigated within the framework of linear theory. Overstability cannot occur if the Prandtl number P > 1 . For overstable oscillations, Rayleigh number is plotted as a function of wave number for several values of the magnetization parameter M 3 . Critical Rayleigh number is found to decrease with increase in M 3 .

Spermatocytic seminoma associated with undifferentiated sarcoma: A rare case report

The presence of sarcomatous element transforms the usually innocuous spermatocytic seminoma into a highly aggressive neoplasm. We report a case of spermatocytic seminoma with undifferentiated sarcomatous component in a 43-year-old male, presented with testicular mass since two and a half years. Orchidectomy was performed and after 9 months, the patient presented with recurrent scrotal mass with bilateral pulmonary metastases.

Isolated Skull Base Metastasis as the First Manifestation of Hepatocellular Carcinoma—A Rare Case Report with Review of Literature

IntroductionHepatocellular carcinoma rarely metastasizes to skull base.Case ReportWe report an extremely rare case of solitary skull base metastasis without metastasis to any other site, with right third, fourth, and sixth cranial nerve palsy as the initial manifestation of the disease.DiscussionThe biopsy specimen of skull base lytic lesion suggested metastatic hepatocellular carcinoma. Subsequent examination revealed a large mass involving superior segment of right lobe of liver, which was confirmed as hepatocellular carcinoma on histopathological examination.ConclusionUntil now, there have been only 24 cases of hepatocellular carcinoma metastasizing to skull base cited in literature. We report here an unusual case of solitary skull base metastasis from hepatocellular carcinoma prior to the diagnosis of primary tumor.

Pathological predictive factors for tumor response in locally advanced breast carcinomas treated with anthracyclin-based neoadjuvant chemotherapy

AIM Neoadjuvant chemotherapy (NACT) is used as a primary treatment for locally advanced breast carcinoma (LABC) and also extended to operable breast cancer. The aim of this study was to evaluate the predictive value of different histological parameters in core biopsy of LABC patients treated with anthracycline-based chemotherapy regimen. Pathological assessment of the excised tumor bed is the gold standard and is essential for identifying the group of patients with pathologic complete response (pCR) or pathologic noncomplete response (pNR). MATERIALS AND METHODS A total of 50 patients with stage II and III breast carcinoma were included in the study. Pretreatment core biopsy histological features include tumor type, histological grade, presence of tumor necrosis, lymphovascular emboli (LVE) and immunohistochemical stains for estrogen receptor (ER) and progesterone receptor (PR) were obtained. Patients were given 3-6 cycles of NACT. Pathological response was assessed. RESULT Seven out of 50 patients achieved pCR. A total of 71.4% patients who achieved pCR had tumor necrosis on initial core biopsy while only 30% pNR cases had this feature (P =0.035). Breast carcinoma other than ductal type was chemoresistant. Of 47 core biopsies, LVE was observed in 13 cases (28 %) of which 11 showed axillary node metastasis. None of these 13 cases had pCR, thus having poor predictive value. CONCLUSION Pathological parameters like type of tumor, presence of LVE and tumor necrosis in the core biopsy can predict the response to NACT in routine stain. Tumor necrosis and type of breast carcinoma are predictive parameters for tumor responsiveness to NACT. LVE was reliable in predicting axillary lymph node metastasis.

Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall

Goblet cell carcinoids are rare tumors of appendix having a mixed phenotype, with partial neuroendocrine differentiation and intestinal type goblet cell morphology. The reported incidence of this tumor is still limited. Till now, only two cases of metastatic goblet cell appendiceal carcinoid on effusion cytology have been reported in literature. We describe the clinico-pathological details and lay stress on fluid cytology of metastatic goblet cell carcinoid to ascitic fluid.

Hydromagnetic stability of a stratified parallel flow varying in two directions

The stability of a stratified parallel flow varying in two directions of an incompressible conducting fluid permeated by a uniform aligned magnetic field is investigated. Complex wave speed of an unstable mode lies in the upper half of a semi-circle whose diameter decreases with increasing magnetic field. It is also found that a strong enough magnetic field can completely stabilize flows with unstable density stratification.

Osteoid differentiation in mesodermal (mullerian) adenosarcoma of ovary.

A 55-year-old female presented with abdominal pain and 10 cm mass per abdominal examination. Computerized tomography scan of abdomen and pelvis revealed a heterogeneously enhancing solid cystic mass right ovarian mass and mild ascites. Surgery was performed. Specimens were sent for examination. Microscopic examination revealed an admixture of benign but occasionally atypical appearing mullerian type glands with sarcomatous stroma. Solid area showed undifferentiated tumour cells. Atypical mitoses and necrosis were also seen. Areas with extensive benign osteoid surrounded by fibroblastic stroma were also present. Glandular component showed positivity for CK-7, AE-1 and EMA while sarcomatous areas showed positivity for vimentin only. Mullerian adenosarcoma of ovary with sarcomatous overgrowth (SO) having heterologous component was confirmed. Postoperative 3 cycles of chemotherapy was given and the patient was well till date (three months after surgery).

Primary Diffuse Large B-cell Lymphoma of Ampulla of Vater: A Rare Case Report

IntroductionPrimary lymphomas of the ampulla of Vater are extremely rare. Among these most frequent are follicular lymphomas followed by mucosa-associated lymphoid tissue-type lymphoma.Case ReportWe report a case of a 36-year-old female diagnosed with diffuse large B-cell lymphoma (DLBCL) of the ampulla of Vater. Endoscopic biopsy was non-diagnostic. Whipple’s resection was performed. The patient was given six cycles of chemotherapy. One year later, the patient developed recurrence at the anastomotic site and again treated with combination chemotherapy. Patient is doing well after 2 years of initial surgery.DiscussionTumors of the ampulla of Vater are included in the pancreaticobiliary group of neoplasms; in some instances, it is almost impossible to ascertain the exact origin of the tumor anatomically. The patients of primary lymphoma of the ampulla of Vater may have a varied clinical presentation or may be completely asymptomatic and detected during routine medical check-ups for gastric cancer screening.ConclusionWe present a rare case of primary DLBCL of the periampullary region. Due to the rarity of these lesions, their ability to masquerade as periampullary carcinomas, and the fact that these tumors show a good response to chemotherapy, an early diagnosis is desirable.

Malignant prolactinoma: A rare case report

Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describe clinico-pathological and immunohistological features of malignant prolactinoma. The patient initially presented with a prolactin-secreting pituitary adenoma. The tumor showed aggressive clinical course presenting with repeated recurrences and eventually metastasized to multiple bones. MIB-1 and p53 labeling indices were also compared in primary adenoma, recurrent invasive adenoma and metastatic tumor.

Hydromagnetic stability of some non-dissipative flows subject to non-axisymmetric disturbances

We study the linear stability of nondissipative flow of an electrically conducting fluid subject to non-axisymmetric disturbances in the following cases: (i) the radial flow of an incompressible fluid between two concentric porous circular cylinders in the presence of a radial magnetic field and (ii) axial flow of a compressible fluid between two concentric circular cylinders permeated by a helical magnetic field (0,B0θ(r),B0z) in a cylindrical coordinate system. It is shown that in case (i), the flow is stable if the Alfvén velocity based on the undisturbed radial magnetic field exceeds the radial velocity due to suction or injection at the cylinder surfaces. In case (ii), it is found that under certain conditions the complex wave speed for an unstable mode lies within a circle of diameterWmax-Wmin, whereWmax andWmin are the maximum and minimum values of the axial velocity in the flow region. In the presence of a purely axial magnetic field, however, the complex wave speed for an unstable mode always lies within the above circle.