Anumula Raghupathi Reddy
Dr. Reddy's Laboratories
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Publication
Featured researches published by Anumula Raghupathi Reddy.
Journal of Pharmaceutical and Biomedical Analysis | 2009
Gilla Goverdhan; Anumula Raghupathi Reddy; K. Srinivas; Vurimidi Himabindu; Ghanta Mahesh Reddy
Zafirlukast is a drug in the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, five unknown impurities were detected at levels of below 0.10% (ranging from 0.05 to 0.15%) in reverse phase gradient high performance liquid chromatography (HPLC) method. The molecular weights were determined by LC-MS analysis. These impurities were isolated from crude samples of zafirlukast using gradient reverse phase preparative HPLC and were subsequently synthesized. Based on the spectral data, the structures of these impurities were characterized as 3-methoxy-4-(5-methoxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-benzoic acid (Impurity 1), {3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-carbamic acid methyl ester (Impurity 2), {3-[2-methoxy-4-(toluene-3-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-acetic acid cyclopentyl ester (Impurity 3), {3-[2-methoxy-4-(toluene-4-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-acetic acid cyclopentyl ester (Impurity 4), and 4-(5-cyclopentyloxy carbonylamino-1-methyl-1H-indol-3-yl methyl)-3-methoxy-benzoic acid methyl ester (Impurity 5). The separation of the impurities by reverse phase HPLC, the confirmation of their structures by IR, MS and NMR spectral data, the mechanism of their formation and their syntheses are discussed in detail.
Synthetic Communications | 2012
Anumula Raghupathi Reddy; Gilla Goverdhan; Aalla Sampath; Khagga Mukkanti; Padi Pratap Reddy; Rakeshwar Bandichhor
Abstract A large scale synthesis of valdecoxib 1 is described. Our work features potential application of [3 + 2]-dipolar cycloaddition involving enamine and in situ–generated nitrile oxide derivatives. GRAPHICAL ABSTRACT
Synthetic Communications | 2013
Gilla Goverdhan; Anumula Raghupathi Reddy; Vurimidi Himabindu; Ghanta Mahesh Reddy
Abstract Concise and alternative synthesis of zafirlukast (1) is described. The synthesis features fewer steps, convergent synthesis, and novel intermediates. GRAPHICAL ABSTRACT
Archive | 2004
Manne Satyanarayana Reddy; Sajja Eswaraiah; Anumula Raghupathi Reddy; Alla Sampath
Organic Process Research & Development | 2009
Anumula Raghupathi Reddy; Alla Sampath; Gilla Goverdhan; Bojja Yakambaram; Kagga Mukkanti; Padi Pratap Reddy
Archive | 2004
Manne Satyanarayana Reddy; Sajja Eswaraiah; Anumula Raghupathi Reddy; Gilla Goverdhan; Emani Srinivasa Reddy; Surasani Rajendra
Organic Process Research & Development | 2009
Gilla Goverdhan; Anumula Raghupathi Reddy; Aalla Sampath; K. Srinivas; Vurimidi Himabindu; Ghanta Mahesh Reddy
Archive | 2004
Anuradha Bhimireddy; Sajja Eswaraiah; Gilla Goverdhan; Koilkonda Purandhar; Surasani Rajendra; Nadimpally Satyavarahala Raju; Anumula Raghupathi Reddy; Emani Srinivasa Reddy; Lekkala Amarnath Reddy; H Padi Prathap No.; Plot No. Reddy; Alla Sampath; Vecha Sravanthi; Venkataraman Sundaram
Journal of The Chinese Chemical Society | 2010
Charagondla Krishnaiah; Anumula Raghupathi Reddy; Ramesh Kumar; Khagga Mukkanti
Journal of Saudi Chemical Society | 2014
Gilla Goverdhan; Anumula Raghupathi Reddy; Vurimidi Himabindu; Ghanta Mahesh Reddy