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Publication


Featured researches published by Anumula Raghupathi Reddy.


Journal of Pharmaceutical and Biomedical Analysis | 2009

Identification, characterization and synthesis of impurities of zafirlukast.

Gilla Goverdhan; Anumula Raghupathi Reddy; K. Srinivas; Vurimidi Himabindu; Ghanta Mahesh Reddy

Zafirlukast is a drug in the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, five unknown impurities were detected at levels of below 0.10% (ranging from 0.05 to 0.15%) in reverse phase gradient high performance liquid chromatography (HPLC) method. The molecular weights were determined by LC-MS analysis. These impurities were isolated from crude samples of zafirlukast using gradient reverse phase preparative HPLC and were subsequently synthesized. Based on the spectral data, the structures of these impurities were characterized as 3-methoxy-4-(5-methoxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-benzoic acid (Impurity 1), {3-[2-methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-carbamic acid methyl ester (Impurity 2), {3-[2-methoxy-4-(toluene-3-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-acetic acid cyclopentyl ester (Impurity 3), {3-[2-methoxy-4-(toluene-4-sulfonylaminocarbonyl)-benzyl]-1-methyl-1H-indol-5-yl}-acetic acid cyclopentyl ester (Impurity 4), and 4-(5-cyclopentyloxy carbonylamino-1-methyl-1H-indol-3-yl methyl)-3-methoxy-benzoic acid methyl ester (Impurity 5). The separation of the impurities by reverse phase HPLC, the confirmation of their structures by IR, MS and NMR spectral data, the mechanism of their formation and their syntheses are discussed in detail.


Synthetic Communications | 2012

Application of [3 + 2]-Cycloaddition in the Synthesis of Valdecoxib

Anumula Raghupathi Reddy; Gilla Goverdhan; Aalla Sampath; Khagga Mukkanti; Padi Pratap Reddy; Rakeshwar Bandichhor

Abstract A large scale synthesis of valdecoxib 1 is described. Our work features potential application of [3 + 2]-dipolar cycloaddition involving enamine and in situ–generated nitrile oxide derivatives. GRAPHICAL ABSTRACT


Synthetic Communications | 2013

Concise and Alternative Synthesis of Zafirlukast, an Anti-Asthma Drug

Gilla Goverdhan; Anumula Raghupathi Reddy; Vurimidi Himabindu; Ghanta Mahesh Reddy

Abstract Concise and alternative synthesis of zafirlukast (1) is described. The synthesis features fewer steps, convergent synthesis, and novel intermediates. GRAPHICAL ABSTRACT


Archive | 2004

Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers

Manne Satyanarayana Reddy; Sajja Eswaraiah; Anumula Raghupathi Reddy; Alla Sampath


Organic Process Research & Development | 2009

An Improved and Scalable Process for Celecoxib: A Selective Cyclooxygenase-2 Inhibitor§

Anumula Raghupathi Reddy; Alla Sampath; Gilla Goverdhan; Bojja Yakambaram; Kagga Mukkanti; Padi Pratap Reddy


Archive | 2004

Process for the preparation of 3-ethoxy-4-(alkoxy carbonyl)-phenyl acetic acid. (an intermediate of repaglinide)

Manne Satyanarayana Reddy; Sajja Eswaraiah; Anumula Raghupathi Reddy; Gilla Goverdhan; Emani Srinivasa Reddy; Surasani Rajendra


Organic Process Research & Development | 2009

An Improved and Scalable Process for Zafirlukast: An Asthma Drug†

Gilla Goverdhan; Anumula Raghupathi Reddy; Aalla Sampath; K. Srinivas; Vurimidi Himabindu; Ghanta Mahesh Reddy


Archive | 2004

Method for preparing 3,4-diphenyl-substituted isoxazole compounds

Anuradha Bhimireddy; Sajja Eswaraiah; Gilla Goverdhan; Koilkonda Purandhar; Surasani Rajendra; Nadimpally Satyavarahala Raju; Anumula Raghupathi Reddy; Emani Srinivasa Reddy; Lekkala Amarnath Reddy; H Padi Prathap No.; Plot No. Reddy; Alla Sampath; Vecha Sravanthi; Venkataraman Sundaram


Journal of The Chinese Chemical Society | 2010

A LC Separation and Quantification of o-Toluene Sulphonamide and its Related Positional Isomers using a Cellulose tris(3,5-dimethyl phenylcarbamate)

Charagondla Krishnaiah; Anumula Raghupathi Reddy; Ramesh Kumar; Khagga Mukkanti


Journal of Saudi Chemical Society | 2014

Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast ☆

Gilla Goverdhan; Anumula Raghupathi Reddy; Vurimidi Himabindu; Ghanta Mahesh Reddy

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Alla Sampath

Dr. Reddy's Laboratories

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Aalla Sampath

Dr. Reddy's Laboratories

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K. Srinivas

Dr. Reddy's Laboratories

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