Aravinda Nanjundappa

Cell transplantation for treatment of left-ventricular dysfunction due to ischemic heart failure: from bench to bedside

Cell transplantation is an innovative technology that involves the implantation of a variety of myogenic and angiogenic cell types. The transplanted cells proliferate and augment left ventricular performance and therein ameliorate the heart failure symptoms. The concept of cell transplantation has followed the footsteps of angiogenesis starting as bench side research. The latter half of the decade saw the transformation of this potential mechanism to a promising therapy for ischemic heart failure. More than 150 patients have been treated with cellular transplantation worldwide. This novel application has the potential to revolultionalize alternative therapeutic approaches to management of heart failure.

Coronary-subclavian steal: Presentation and management : Two case reports

Subclavian stenosis is a highly prevalent and underrecognized clinical entity. In patients with a history of coronary artery bypass grafting utilizing a left internal mammary artery, subclavian artery stenosis can cause coronary-subclavian steal, leading to myocardial ischemia. Traditionally, this has been treated surgically with a vascular bypass operation. Two cases of coronary-subclavian steal syndrome are presented, 1 treated percutaneously with angioplasty and stent, and 1 treated with a combined endovascular-surgical procedure.

Coronary Angioplasty and Newer Interventional Strategies

Cardiac catheterization was initially attempted in cadavers around 400 BC. The first successful cardiac catheterization was carried out by Dr Werner Frossmann on himself in 1929 [1]. A catheter was self-introduced via the left anticubital vein into the right atrium at a small hospital in Eberswald, Germany. Dr Frossmann, an innovator, was clearly ahead of his time. Several decades later in the year 1958, Dr Mason Sones accidentally discovered that coronary arteries could be safely injected with contrast dye and studied [2] the coronary arteries at a Cleveland clinic in Ohio, USA.

Cardiac Catheterization and Selective Coronary Angiography: Current Status and Limitations

Cardiac catheterization and selective coronary angiography has revolutionized the evaluation of cardiac anatomy and physiology over the past three decades. In an age of advanced noninvasive cardiac imaging, selective coronary angiography remains the gold standard for defining cardiac anatomy. In addition to defining the site, severity, and morphology of coronary lesions, cardiac catheterization provides the most accurate quantitative assessment of cardiac structure and hemodynamics.