Ariella A. Friedman

National Trends and Disparities in the Use of Minimally Invasive Adult Pyeloplasty

PURPOSE Minimally invasive pyeloplasty might have several advantages compared to open pyeloplasty in the management of ureteropelvic junction obstruction. Nonetheless, minimally invasive pyeloplasty appears to be underused in North America. We examined specific patient and hospital characteristics that may be associated with these disparities. MATERIALS AND METHODS The Nationwide Inpatient Sample was used to identify a national estimate of 29,456 patients with ureteropelvic junction obstruction treated with minimally invasive pyeloplasty (laparoscopic or robotic) and open pyeloplasty between 1998 and 2009. The rates of use of minimally invasive and open pyeloplasty were assessed according to year of surgery, and patient and hospital characteristics. The determinants of minimally invasive pyeloplasty were evaluated using logistic regression models adjusted for clustering. RESULTS Overall 15.3% of patients underwent minimally invasive pyeloplasty between 1998 and 2009. The use of minimally invasive pyeloplasty increased remarkably during the study period from 2.4% to 55.3%, a 23-fold increase. On multivariable logistic regression analysis African-American race (OR 0.584, p = 0.015) and other insurance status (including uninsured patients, OR 0.613, p = 0.013) were associated with a lower rate of minimally invasive pyeloplasty. Patients treated at teaching (OR 1.788, p = 0.003) and/or urban (OR 4.819, p <0.001) institutions were significantly more likely to undergo minimally invasive pyeloplasty. CONCLUSIONS In the last decade there has been a dramatic increase in the use of minimally invasive pyeloplasty in the United States and in 2009 a slight majority underwent minimally invasive pyeloplasty. Nonetheless, treatment disparities exist. African-American patients with other insurance status (including those uninsured) treated at nonteaching, rural hospitals were less likely to undergo minimally invasive pyeloplasty. Efforts should be made to understand these treatment disparities and broaden the availability of minimally invasive pyeloplasty.

THE IMPACT OF HOSPITAL VOLUME, RESIDENCY AND FELLOWSHIP TRAINING ON PERIOPERATIVE OUTCOMES AFTER RADICAL PROSTATECTOMY

OBJECTIVES Although high-volume hospitals have been associated with improved outcomes for radical prostatectomy (RP), the association of residency or fellowship teaching institutions or both and this volume-outcome relationship remains poorly described. We examine the effect of teaching status and hospital volume on perioperative RP outcomes. METHODS AND MATERIALS Within the Nationwide Inpatient Sample, we focused on RPs performed between 2003 and 2007. We tested the rates of prolonged length of stay beyond the median of 3 days, in-hospital mortality, and intraoperative and postoperative complications, stratified according to teaching status. Multivariable logistic regression analyses further adjusted for confounding factors. RESULTS Overall, 47,100 eligible RPs were identified. Of these, 19,193 cases were performed at non-teaching institutions, 24,006 at residency teaching institutions, and 3,901 at fellowship teaching institutions. Relative to patients treated at non-teaching institutions, patients treated at fellowship teaching institutions were healthier and more likely to hold private insurance. In multivariable analyses, patients treated at residency (OR = 0.92, P = 0.015) and fellowship (OR = 0.82, P = 0.011) teaching institutions were less likely to experience a postoperative complication than patients treated at non-teaching institutions. Patients treated at residency (OR = 0.73, P<0.001) and fellowship (OR = 0.91, P = 0.045) teaching institutions were less likely to experience a prolonged length of stay. CONCLUSIONS More favorable postoperative complication profile and shorter length of stay should be expected at residency and fellowship teaching institutions following RP. Moreover, postoperative complication rates were lower at fellowship teaching than at residency teaching institutions, despite adjustment for potential confounders.

Is there a relationship between leapfrog volume thresholds and perioperative outcomes after radical cystectomy

OBJECTIVE Threshold levels for hospital volume (HV), defined by the Leapfrog Group for Patient Safety, advocate the concentration of high-risk medical care to high-volume hospitals in order to avail of these outcome benefits. We explored the effect of Leapfrog volume thresholds (LVT) on 5 short-term radical cystectomy (RC) outcomes. MATERIALS AND METHODS Within the Health Care Utilization Project Nationwide Inpatient Sample, we focused on RCs performed between 2001 and 2007. We tested the rates of in-hospital mortality, intraoperative and postoperative complications, blood transfusions, as well as length of stay, stratified according to the number of LVT met. Multivariable regression analyses further adjusted for potential confounders. RESULTS Overall, 28.6%, 17.1%, 18.8%, 17.0%, 15.4%, and 3.1% of cases were performed at institutions reaching 0, 1, 2, 3, 4, and 5 LVT, respectively. Patients treated at institutions reaching 5 LVT had fewer comorbidities, were younger, and more likely to hold private insurance, relative to patients treated at institutions reaching 0 LVT. In adjusted analyses, after accounting for patient characteristics and HV, LVT status was inversely related to mortality (P = 0.030), intraoperative (P = 0.042) and postoperative (P = 0.041) complications, as well as the likelihood of blood transfusion (P<0.001). CONCLUSIONS LVT is an important determinant of the risk of mortality, complications, and blood transfusions after RC, independent of HV. These findings hint at intrinsic structural and procedural elements available within hospitals that meet LVT, which enable them to manage complications, and prevent mortality, in a more optimal manner.

Radiation Safety Knowledge and Practices Among Urology Residents and Fellows: Results of a Nationwide Survey

INTRODUCTION Reliance upon fluoroscopy within urology is increasing, with urologists key in determining radiation exposure to patients, themselves, and other healthcare personnel. However, education in occupational radiation safety is nonstandardized, often lacking. Consequently, residents and practicing urologists risk overexposure. We assessed occupational radiation safety attitudes and practices of training urologists. METHODS A confidential, anonymous, internet-based survey on workplace radiation safety practices was distributed to residents and fellows via program directors identified from the American College of Graduate Medical Education and the American Osteopathic Association. Items explored included sources of education on occupational radiation exposure, knowledge of occupational dose limits, exposure frequency, and protective item utilization. Investigators were blinded to responses. RESULTS Overall, 165 trainees responded, almost all of whom reported at least weekly workplace radiation exposure. Compliance with body and thyroid shields was high at 99% and 73%, respectively. Almost no one used lead-lined glasses and gloves; three-quarters cited lack of availability. The principle of keeping radiation doses As Low As Reasonably Achievable (ALARA) was widely practiced (88%). However, 70% of respondents never used dosimeters, while 56% never had one issued. Only 53% felt adequately trained in radiation safety; this number was 30% among those pregnant during training. Fewer than half (46%) correctly identified the maximum acceptable annual physician exposure. Departmental education in radiation safety improved knowledge, protective practices, monitoring, and satisfaction with education in radiation exposure. CONCLUSIONS Our findings show that protective equipment usage and occupational radiation monitoring for the training urologist are insufficient. Despite frequent exposure, resident education in radiation safety was found lacking. Efforts should be made to address these deficiencies on a local and national level.

Radical Cystectomy in the Elderly: National Trends and Disparities in Perioperative Outcomes and Quality of Care

Introduction: To examine national trends of radical cystectomy (RC) for urothelial carcinoma of urinary bladder in octogenarian patients and to assess the rates of adverse outcomes. Materials and Methods: Within the Nationwide Inpatient Sample (NIS), we focused on RCs performed between 1998 and 2007. Age was stratified as <80 versus ≥80 years. Propensity-based matched analyses were used to account for treatment selection biases. Generalized linear regression analyses were fitted to predict adverse perioperative events according to age. Results: Of 12,274 RC patients, 1,605 were ≥80 years (13.1%). The RC rates in octogenarians increased significantly from 9.9% in 1998 to 13.7% in 2007. Most elderly patients were treated at low-/intermediate-volume hospitals (81.7%) and nonacademic centers (60.6%). After propensity score matching, the inpatient mortality rate was higher in octogenarians (4.6 vs. 2.6%, p < 0.001). In multivariable analyses, octogenarians were at increased risk of blood transfusions (OR: 1.30) and postoperative complications (OR: 1.22). Conclusions: Most octogenarians undergoing RC are treated at low-/intermediate-volume hospitals and at nonacademic centers. The inpatient hospital mortality is about twice as high in these patients, and adverse perioperative outcomes are more frequent. Such patients may benefit from RC at high-volume and/or academic centers to maximally reduce adverse perioperative outcomes.

Risk factors for biochemical recurrence following radical perineal prostatectomy in a large contemporary series: A detailed assessment of margin extent and location

OBJECTIVES The implications of positive surgical margin (PSM) extent and location during radical perineal prostatectomy (RPP) have not been assessed in a contemporary series. We aimed to examine the incidence, location, and extent of PSM as well as their impact on biochemical recurrence (BCR) following RPP. MATERIALS AND METHODS A total of 794 patients underwent RPP by a single surgeon between June 1993 and August 2010. Covariates included age, pathologic T stage, pathologic Gleason sum, preoperative PSA, prostate volume, PSM extent, and location. Life table, Kaplan-Meier, and Cox regression analyses assessed predictors of BCR following RPP. RESULTS PSM were recorded in 162 patients (20.4%); of these, 83 (51.2%) were focal (≤ 1 mm) whereas 79 (48.8%) were broad (>1 mm). Location of PSM was anterior 10.5%, posterior or lateral 14.8%, bladder neck 23.5%, apical 32.1%, and multifocal 19.1%. At a median follow-up of 54 months, the 5-year BCR-free probability was 90.8% in patients with negative margins, 77.5% in patients with focal PSM, and 47.5% in patients with broad PSM. On multivariable analyses adjusted for age, pathologic T stage, pathologic Gleason sum, preoperative PSA, and prostate volume, broad PSM, (HR = 3.49, P < 0.001) as well as anterior (HR = 3.77, P = 0.003), bladder neck (HR = 2.25, P = 0.01) and multifocal (HR = 3.55, P < 0.001) PSM were independent predictors of BCR. CONCLUSIONS In this study, we present oncologic outcomes following RPP in a large contemporary cohort of patients undergoing RPP. In adjusted analyses, broad and anterior PSM carried the highest risk of recurrence after RPP.

Robotic nephrolithotomy and pyelolithotomy with utilization of the robotic ultrasound probe

INTRODUCTION The treatment of large renal stones in children can be challenging often requiring combination therapy and multiple procedures. The purpose of this video is to describe our technique of robotic nephrolithotomy and pyelolithotomy for complex renal stone disease in children, and to demonstrate the utility of the robotic ultrasound probe to aid with stone localization. MATERIALS AND METHODS Robotic nephrolithotomy/pyelolithotomy was carried out in four consecutive patients. A robotic ultrasound probe (Hitachi-Aloka, Tokyo, Japan) under console surgeon control was used in all cases. RESULTS Two patients underwent robotic pyelolithotomy, one patient underwent robotic nephrolithotomy, whilst the fourth patient underwent robotic pyelolithotomy and nephrolithotomy along with Y-V pyeloplasty for concurrent ureteropelvic junction obstruction. Mean operative time, blood loss and hospital stay was 216 minutes, 37.5 mL and 2 days, respectively. The robotic ultrasound probe aided identification of calculi within the kidney in all cases. For nephroli¬thotomy it was helpful in planning the incision for nephrotomy. After nephrotomy or pyelotomy, stones were removed using a combination of robotic Maryland forceps, fenestrated grasper or Prograsp. Antegrade nephroscopy introduced through a laparoscopic port was used in all patients for confirmation of residual stone status. Two patients did not require a ureteral stent in the post-operative period. One patient had a minor complication (Clavien Grade 2 - dislodged malecot catheter). All patients were stone free at last follow-up. CONCLUSIONS Robotic nephrolithotomy and pyelolithotomy with utilization of the robotic ultrasound probe offers a one-stop solution for complex renal stones with excellent stone-free rates.

Corrigendum: Inpatient hypospadias care: Trends and outcomes from the American nationwide inpatient sample

[This corrects the article on p. 594 in vol. 56, PMID: 26279829.].

Complete endoscopic management of a retained bullet in the bladder

A 25-year-old male gunshot victim presented at our institution with gross hematuria following Foley catheter insertion. Computed tomography and cystogram did not show a bladder perforation, but were notable for a left ischial fracture and the presence of a bullet within the bladder. After failed attempts at retrieving the bullet with a resectoscope and loop, as well as a cystoscope and stone crusher, a 26 French nephroscope was inserted transurethrally, and the bullet was successfully engaged and removed using a Perc NCircle (Cook Medical, Bloomington, IN) grasper. The extra-peritoneal injury was managed conservatively with catheter drainage. To our knowledge, this represents the first case of successful transurethral management of a retained intravesical bullet. Such an approach may benefit patients with retained intravesical bullets or other challenging intravesical foreign bodies and may be helpful in select circumstances to spare patients from more extensive surgeries.

Inpatients hypospadias care: Trends and outcomes from the American nationwide inpatient sample

Purpose Hypospadias is the most common congenital penile anomaly. Information about current utilization patterns of inpatient hypospadias repair as well as complication rates remain poorly evaluated. Materials and Methods The Nationwide Inpatient Sample was used to identify all patients undergoing inpatient hypospadias repair between 1998 and 2010. Patient and hospital characteristics were attained and outcomes of interest included intra- and immediate postoperative complications. Utilization was evaluated temporally and also according to patient and hospital characteristics. Predictors of complications and excess length of stay were evaluated by logistic regression models. Results A weighted 10,201 patients underwent inpatient hypospadias repair between 1998 and 2010. Half were infants (52.2%), and were operated in urban and teaching hospitals. Trend analyses demonstrated a decline in incidence of inpatient hypospadias repair (estimated annual percentage change, -6.80%; range, -0.51% to -12.69%; p=0.037). Postoperative complication rate was 4.9% and most commonly wound-related. Hospital volume was inversely related to complication rates. Specifically, higher hospital volume (>31 cases annually) was the only variable associated with decreased postoperative complications. Conclusions Inpatient hypospadias repair have substantially decreased since the late 1990s. Older age groups and presumably more complex procedures constitute most of the inpatient procedures nowadays.