Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Arkadiusz Krzyżanowski is active.

Publication


Featured researches published by Arkadiusz Krzyżanowski.


PLOS ONE | 2015

Peripheral Dendritic Cells and CD4+CD25+Foxp3+ Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage.

Maciej Kwiatek; Tomasz Gęca; Arkadiusz Krzyżanowski; Agnieszka Malec; Anna Kwaśniewska

The development of pregnancy is possible due to initiation of immune response in the body of the mother resulting in immune tolerance. Miscarriage may be caused by the impaired maternal immune response to paternal alloantigens located on the surface of trophoblast and fetal cells. The aim of the study was to compare the population of circulating dendritic cells (DCs) and CD4+CD25+Foxp3+ regulatory T cells (TREGs) in the first trimester of a normal pregnancy and in women with recurrent miscarriage and an attempt to determine the relationship between these cells and the role they may play in human reproductive failures. The study was conducted in a group of 33 first trimester pregnant women with recurrent miscarriage and in a group of 20 healthy pregnant women in the first trimester of normal pregnancy. Among mononuclear cells isolated from peripheral blood, the populations of DCs and TREGs were assessed by flow cytometry. The percentage of myeloid DCs and lymphoid DCs showed no significant difference between study and control group. Older maternal age and obesity significantly reduced the pool of circulating myeloid and lymphoid DCs (R=-0.39, p=0.02). In miscarriages the percentage of circulating TREGs was significantly lower compared to normal pregnancies (p=0.003). Among the analysed factors the percentage of TREGs was the most sensitive and the most specific parameter which correlated with the pregnancy loss. The reduction in the population of circulating TREGs suggests immunoregulatory mechanisms disorder in a pregnancy complicated by miscarriage.


Australian & New Zealand Journal of Obstetrics & Gynaecology | 2018

Prenatal diagnosis of persistent right umbilical vein – Incidence and clinical impact. A prospective study

Arkadiusz Krzyżanowski; Dariusz Swatowski; Tomasz Gęca; Maciej Kwiatek; Aleksandra Stupak; Sławomir Woźniak; Anna Kwaśniewska

Persistent right umbilical vein (PRUV) is usually an isolated finding but it may be accompanied by other fetal malformations.


Journal of Medical Case Reports | 2014

Complementary role of magnetic resonance imaging after ultrasound examination in assessing fetal renal agenesis: a case report.

Tomasz Gęca; Arkadiusz Krzyżanowski; Aleksandra Stupak; Anna Kwaśniewska; Tomasz Pikuła; Radosław Pietura

IntroductionUltrasonography is used routinely during pregnancy to screen and detect fetal abnormalities. However, there are some conditions like anhydramnios (a prevalent state in renal agenesis) or maternal obesity that may limit the diagnostic accuracy of ultrasonography. Magnetic resonance imaging has proven to be useful when ultrasound alone is insufficient to make a correct diagnosis.Case presentationWe present the case of a 22-year-old Caucasian woman who was admitted to our unit at the 26th week of gestation for a detailed anatomy scan. Anhydramnios and failure to visualize the kidneys, bladder and renal vessels were confirmed with the use of sonography in our department. Since the lack of amniotic fluid limited the acoustic window for fetal ultrasonography, a magnetic resonance imaging scan was requested to confirm suspected renal agenesis. A fetal magnetic resonance imaging scan was performed and confirmed the suspected diagnosis. A baby boy was born by breech vaginal delivery after spontaneous onset of labor at the 34th week of gestation. The boy weighed 1690g, with Apgar scores of 6 and 4 at two and five minutes respectively, and died one hour after delivery. The diagnosis of bilateral renal agenesis was confirmed on autopsy.ConclusionsThe aim of this study was to evaluate the potential contribution of magnetic resonance imaging in diagnostic procedure after inconclusive ultrasound examination during the assessment of fetal urinary tract abnormalities in the third trimester.


Medical Science Monitor | 2017

Phenotypic Characterization of Adherent Cells Population CD34+ CD90+ CD105+ Derived from Wharton’s Jelly

Irena Walecka; Paulina Gil-Kulik; Arkadiusz Krzyżanowski; Marcin Czop; Dariusz Galkowski; Jolanta Karwat; Piotr Chomik; Małgorzata Świstowska; Anna Kwaśniewska; Anna Bogucka-Kocka; Janusz Kocki

Background Mesenchymal stromal cells, MSCs, show expression of specific antigens on their surface. The aim of the study is to assess the phenotype of stem cells like isolated from the umbilical cord with respect to the presence of surface antigens CD34, CD90, and CD105 and differences in the expression of surface antigens in cells isolated from freshly sampled material in comparison with the phenotype of cells from in vitro culture. Material/Methods Stem cells collected from the umbilical cord from healthy patients and then cultured in vitro. To assess the phenotype of stem cells, cytometric analysis was carried out. To assess the phenotype of cells we used fluorescently labelled monoclonal antibodies: APC Mouse anti-human CD34, PC5 Mouse anti-human CD90 and PE Mouse anti-human CD105. Results In the case of cells from the umbilical cord and then cultured in vitro for the period of 10–14 days CD34 expression is lower (69,5%) in comparison with the group of cells not cultured. Not cultured cells were demonstrated 37% of cells co-expression of antigens CD34 and CD105, over 21% of CD34/CD90 cells and over 24% of CD105/CD90. Cultured cells group was showed higher percentage of CD90, CD105, CD34/CD105, CD34/CD90, CD105/CD90 in comparison with not cultured cells. Conclusions Our reults suggested that adherent cells population from umbilical cord, demonstrate CD34 expression In vivo. Moreover, the phenotype of MSCs, mainly in the context of CD34 expression, may vary depending on the place of collection of cells and the length of growing the cell culture.


Polish Journal of Public Health | 2015

Chromosomal abnormalities in a decade of prenatal testing at the Department of Obstetrics and Pathology of Pregnancy Medical University of Lublin

Arkadiusz Krzyżanowski; Tomasz Gęca; Maciej Kwiatek; Anna Kwaśniewska

Abstract Introduction. Chromosomal abnormalities, one of the leading causes of pregnancy complications, attract attention of both researchers and clinicians. They use two approaches to identify chromosomal abnormalities, namely screening and diagnostic tests. Ultrasonography is a very reliable screening and diagnostic tool, but the only way to determine if there are any chromosomal defects in the fetus, is performing one of invasive diagnostics tests chorionic villus sampling (CVS), cordocentesis or amniocentesis. Unfortunately, these invasive diagnostic procedures carry a potentially high risk of complications. Using amniocentesis means a procedure-related miscarriage risk at a rate of about 0.5-1%. Aim. The aim of this paper was to present our own experience, results in performing amniocentesis and a review of the literature. Material and methods. During a 10-year period 237 mid-trimester, transabdominal amniocenteses were performed. Results. The follow-up revealed one spontaneous abortion within seven days after the procedure. Premature delivery occurred in fourteen cases (two of them with chromosomal abnormalities). No neonatal deaths related to amniocentesis were noticed. Chromosomal abnormalities were detected in 33 patients. Conclusions. In the group with chromosomal abnormalities the main indications to perform amniocentesis were: improper ultrasound scan and the first trimester biochemical, noninvasive screening tests. This is a proof that modern, non-invasive procedures like the first-trimester ultrasound scan and biochemical tests should be made available to every pregnant woman and not only to mothers’ aged >35 years or those with a poor obstetrics history.


Ginekologia Polska | 2007

Maternal serum concentration of placental growth factor (PIGF) and endothelial growth factor (VEGF) in pregnancies complicated by preeclampsia

Anna Semczuk-Sikora; Arkadiusz Krzyżanowski; Maciej Kwiatek; Marian Semczuk


Ginekologia Polska | 2007

[Maternal serum concentration of angiogenic factors: PIGF, VEGF and VEGFR-1 and placental volume in pregnancies complicated by intrauterine growth restriction].

Anna Semczuk-Sikora; Arkadiusz Krzyżanowski; Norbert Stachowicz; Jacek Marcin Robak; Janusz Kraczkowski; Maciej Kwiatek; Marian Semczuk


Journal of Medical Ultrasonics | 2014

Conservative management after prenatal ultrasound diagnosis of meconium periorchitis.

Aleksandra Stupak; Arkadiusz Krzyżanowski; Anna Semczuk-Sikora; Izabela Dymanowska-Dyjak; Tomasz Gęca; Adrianna Kondracka; Anna Kwasniewska


Ginekologia Polska | 2014

Ultrasound evaluation of fetal adrenal gland volume. The role of fetal adrenal glands in the pathogenesis of preterm labor

Arkadiusz Krzyżanowski; Katarzyna Karwasik-Kajszczarek; Izabela Dymanowska-Dyjak; Adrianna Kondracka; Anna Kwaśniewska


Postepy Higieny I Medycyny Doswiadczalnej | 2018

The influence of IGF-1 on fetal growth during pregnancy complicated by gestational diabetes mellitus

Tomasz Gęca; Maciej Kwiatek; Arkadiusz Krzyżanowski; Anna Kwaśniewska

Collaboration


Dive into the Arkadiusz Krzyżanowski's collaboration.

Top Co-Authors

Avatar

Anna Kwaśniewska

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Tomasz Gęca

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Maciej Kwiatek

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Aleksandra Stupak

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Anna Semczuk-Sikora

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Marian Semczuk

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Adrianna Kondracka

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Radosław Pietura

Medical University of Lublin

View shared research outputs
Top Co-Authors

Avatar

Agnieszka Malec

Medical University of Lublin

View shared research outputs
Researchain Logo
Decentralizing Knowledge