Arlene Gwon
University of California, Irvine
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Publication
Featured researches published by Arlene Gwon.
Eye & Contact Lens-science and Clinical Practice | 2016
Brad Gray; Perry S. Binder; Ling C. Huang; James M. Hill; Mercedes Salvador-Silva; Arlene Gwon
Objectives: To compare morphologic differences between freehand diamond or femtosecond laser-assisted penetrating and intrastromal arcuate incisions. Methods: Freehand diamond blade, corneal arcuate incisions (180° apart, 60° arc lengths) and 150 kHz femtosecond laser (80% scheimpflug pachymetry depth corneal thickness) arcuate incisions were performed in rabbits. Intrastromal arcuate incisions (100 &mgr;m above Descemets membrane, 100 &mgr;m below epithelium) were performed in rabbit corneas (energy 1.2 &mgr;J, spot line separation 3 × 3 &mgr;m, 90° side cut angle). Eyes were examined by slit lamp and light microscopy up to 47 days post-procedure. Freehand diamond blade penetrating incisions, and femtosecond laser penetrating and intrastromal arcuate incisions (energy 1.8 &mgr;J, spot line separation 2 × 2 &mgr;m) were performed in cadaver eyes. Optical coherence tomography was performed immediately after surgery and the corneas were fixed for light scanning and transmission electron microscopy. Results: The rabbit model showed anterior stromal inflammation with epithelial hyperplasia in penetrating blade and laser penetrating wounds. The laser intrastromal and penetrating incisions showed localized constriction of the stromal layers of the cornea near the wound. In cadaver eyes, penetrating wound morphology was similar between blade and laser whereas intrastromal wounds did not affect the cornea above or below incisions. Conclusion: Penetrating femtosecond laser arcuate incisions have more predictable and controlled outcomes shown by less post-operative scarring than incisions performed with a diamond blade. Intrastromal incisions do not affect uncut corneal layers as demonstrated by histopathology. The femtosecond laser has significant advantages in its ability to make intrastromal incisions which are not achievable by traditional freehand or mechanical diamond blades.
Investigative Ophthalmology & Visual Science | 1993
Arlene Gwon; L J Gruber; C Mantras; C Cunanan
Investigative Ophthalmology & Visual Science | 1990
Arlene Gwon; L J Gruber; K E Mundwiler
Investigative Ophthalmology & Visual Science | 1992
Arlene Gwon; R L Jones; L J Gruber; C Mantras
Investigative Ophthalmology & Visual Science | 1993
Arlene Gwon; C Mantras; L J Gruber; C Cunanan
Investigative Ophthalmology & Visual Science | 2012
Brad Gray; Ling C. Huang; James M. Hill; Mercedes Salvador-Silva; Arlene Gwon; Perry S. Binder; Michael Brownell
Investigative Ophthalmology & Visual Science | 2007
Arlene Gwon; L. Gruber
Investigative Ophthalmology & Visual Science | 2015
Ling C. Huang; Mercedes Salvador-Silva; Tim I. Hunter; Arlene Gwon
Investigative Ophthalmology & Visual Science | 2012
James E Hill; Ling C. Huang; Brad Gray; Patrick De Guzman; Arlene Gwon; Luis G. Vargas; Michael Brownell
Investigative Ophthalmology & Visual Science | 2012
Roger F. Steinert; Perry S. Binder; Brad Gray; Zsolt Bor; Michael Brownell; Jaime Martiz; Arlene Gwon; James M. Hill; Luis G. Vargas