Arliss H. Tuttle

Renal hemodynamic studies in adults with sickle cell anemia

Abstract Renal hemodynamics have been measured in ten adult patients with sickle cell anemia between the ages of sixteen and thirty-seven. The GFR, ERPF and Tm(PAH) are supra-normal during early adulthood, as in children, but to a lesser extent. Between twenty and thirty years of age these functions begin to decrease, with early and greater alterations occurring in the GFR. After the third decade all functions are seriously affected. The GFR/ERPF is decreased but attributed to a disproportionate decrease in GFR in older adults. In children and young adults the decrease in GFR/ERPF is attributable to a disproportionate increase in the ERPF. The GFR/Tm(PAH) decreased with age which indicates a disproportionate decrease in GFR. The ERPF/Tm(PAH) and ERBF/Tm(PAH) indicative of tubular perfusion of plasma and blood, respectively, decreased progressively from abnormally high to subnormal values from childhood through adulthood.

Cyclophosphamide in the treatment of common neoplastic diseases of childhood

Cyclophosphamide, a new alkylating agent, was administered to 59 children with neoplastic disease. Long-term continuous therapy was employed. The drug dosage was adjusted by the white blood count since depression of granulocyte production occurred at doses that have little effect on erythrocyte and thrombocyte production. Alopecia and hemorrhagic cystitis were frequent. Temporary remissions occurred in patients with lymphomas and in 6 of 16 children with acute leukemia. There was temporary regression of tumor in patients with neuroblastoma, rhabdomyosarcoma, Ewings sarcoma, and malignant teratoma. Cyclophosphamide seemed most useful for palliation or in combination with operation and/or radiation. The likelihood that cyclophosphamide alone will cure any of the diseases treated seems remote.

Clinical and hematological manifestations of hemoglobin CS disease in children.

D u R I N C the past decade many genetically determined variants of human hemoglobin have been discovered, and the relation of inherited abnormalities in hemoglobin synthesis to clinical disease has become of increasing interest and importance in many disciplines of medicine. The most frequently encountered abnormal hemoglobins in this country are.Hgb. S and Hgb. C which are found principally in members of the Negro race. The gene responsible for Hgb. S synthesis occurs in approximately 9 per cent of American Negroes and the one responsible for Hgb. C synthesis is present in approximately 3 per cent of our Negro population? These abnormal genes may be inherited in heterozygous combination with the gene for normal adult hemoglobin, Hgb. A, resulting in the combination Hgb. AS (sickle cell trait) or Hgb. AC (hemoglobin C trait), in the homozygous corabinations Hgb. SS (sickle cell anemia) or Hgb. CC (hemo-

Hemoglobin Types of Macaca irus and Macaca mulatta Monkeys

Hemoglobin of 30 Macaca mulatta monkeys and of 15 Macaca irus monkeys consisted of one electrophoretic component similar to human hemoglobin A. Twenty-one M. irus monkeys had two types of hemoglobin. In 20 animals the hemoglobin resembled human hemoglobin AJ, and in one animal it resembled human hemoglobin AI.