Armelle Prunier

Pre-emptive meloxicam for postoperative analgesia in piglets undergoing surgical castration.

OBJECTIVEnTo investigate the effect of preoperative meloxicam administration on postoperative stress and pain induced by surgical castration in piglets.nnnSTUDY DESIGNnProspective, blinded, randomized clinical trial.nnnANIMALSnOne hundred and eighty male piglets of <1 week of age.nnnMETHODSnCastration was performed on 150 piglets which had received either an intramuscular injection of 0.4 mg kg(-1) meloxicam or a placebo 10-30 minutes before the procedure. Blood cortisol and ACTH concentrations were determined at 30 minutes post-castration and haptoglobin was measured at 24 hours post-castration. Presence or absence of foreleg movements, hind leg movements, urine or faeces emission, tremors or other body movements were recorded during the castration procedure. Scores for presence or absence of prostration, tremors, tail movements and isolation were recorded at 30 minutes, and at 1, 2, 4 and 24 hours post-castration and combined in a global behaviour score (GBS). Blood samples were taken from a further 30 piglets which did not undergo castration.nnnRESULTSnMean blood cortisol and ACTH concentrations at 30 minutes post-castration were both significantly lower in the meloxicam group than in the placebo group (p < or = 0.01). The mean haptoglobin concentration at 24 hours was not significantly reduced (p = 0.178). The distribution of the GBS during castration was similar in both groups. There were significant differences in the GBS after castration at both 2 and 4 hours post-castration with a greater proportion of piglets in the meloxicam group showing no behavioural alterations (82.7%versus 68.0% at both time points). The score distribution was similar in both groups at 30 minutes, 1 and 24 hours after castration.nnnCONCLUSION AND CLINICAL RELEVANCEnThis study suggests that pre-emptive administration of meloxicam is able to produce some postoperative analgesia after surgical castration of young piglets.

Genetic relationships between measures of sexual development, boar taint, health, and aggressiveness in pigs.

Breeding intact boars is a promising alternative to surgical castration of piglets. Genetic selection should enable farmers to solve problems due to boar taint and aggressiveness while taking into account potential consequences on other traits of interest. The aim of the study was to estimate genetic relations between sexual development, boar taint, health, and aggressiveness. About 1,600 Pietrain (purebred) or Pietrain × Large White (crossbred) boars were raised in a testing station. Blood samples were collected at about 105 kg BW for measuring sex hormones (testosterone and estradiol) and indicators of the inflammatory status (C-reactive protein [CRP], pig major acute-phase protein [pigMAP], and blood formula). Animals were slaughtered 9 d later and measured for boar taint compounds present in fat (androstenone and skatole) and skin lesions on carcass, an indicator of aggressiveness. For both genetic types, heritability was moderate for sex hormones (from 0.17 to 0.29) and skatole (0.24 for purebred and 0.37 for crossbred) and high for androstenone (0.63 and 0.70 for purebred and crossbred, respectively). Genetic correlations between sex hormones and boar taint compounds were moderate to high (from 0.31 to 0.95). Heritability was moderate for CRP (0.24 and 0.46 for purebred and crossbred, respectively) and very low for pigMAP (0.06 and 0.05 for purebred and crossbred, respectively. Numbers of leukocytes had moderate to high heritabilities according to the genetic type (from 0.21 to 0.52). Heritability of skin lesions was moderate for both genetic types (0.31). Genetic correlations were negative between sex hormones and inflammatory measures (from -0.46 to -0.05), positive between testosterone and number of lesions (0.43 and 0.53 for purebred and crossbred, respectively), and low between androstenone and lesions (-0.06 and -0.17 for purebred and crossbred, respectively). Overall, both breeds of pigs had very similar estimations of heritabilities, but estimates of genetic correlations were different for some pairs of traits. It would be possible to select boars based on their plasma concentration of sex hormones to decrease boar taint and aggressiveness without important consequences on the immune response. However, because of the strong links between boar taint and reproductive function, the possible consequences on the reproductive performance should be evaluated.

Influence of the housing environment during sow gestation on maternal health, and offspring immunity and survival

In pig husbandry, pregnant females are often exposed to stressful conditions that may affect their physiology, behaviour or health and consequently the ability of their offspring to survive and develop. This study compared two different housing systems from insemination to 106 days of gestation, a conventional (C) and an enriched one (E), for maternal cortisol and immune parameters, as well as for the immune function and survival of their offspring. The C and E systems differed essentially for the housing design (slatted floor, 2.4 m2 per sow vs a deep straw litter and 3.4 m2 per sow). Results from Expt 1 (n = 108) demonstrated that C sows had higher salivary cortisol than E sows at gestational Day 102 (DG 102). Results from Expt 2 (n = 48) showed that, at DG 102, C sows had higher granulocyte counts and total plasma immunoglobulin G concentration than E sows, whereas lymphocyte number, haematocrit and haptoglobin plasma concentration were similar. Results from Expt 3 (n = 47) showed that plasma immunoglobulin G level at 5 and 27 days of age, hematocrit, white blood cell numbers and in vitro lymphocyte proliferation of piglets at 27 days of age were not influenced by maternal housing conditions. However, reproductive data collected in Expt 2 and 3 indicated that pre-weaning mortality was higher in C than E litters. In conclusion, the C system was associated with markers of increased stress and microbial aggression in gestating sows, and with greater piglet mortality during the suckling period without identified alterations in piglet immune function.