Armelle Sauleau

γ-Methyl-substituted-γ-butyrolactones: solid-phase synthesis employing a cyclisation–cleavage strategy

Abstract The solid-phase synthesis of several γ-methyl-substituted-γ-butyrolactones using a cyclisation–cleavage reaction is reported. Chemical modifications of polymer-bound azido (2a) and iodo alcohols (2b) were realised in order to introduce additional diversity onto the lactone structure.

Solid‐phase Synthesis, Antiviral Activity and Cytotoxicity of Some Functionalized Lactones

Thio-substituted γ- and δ-lactones were prepared via a resin-bound epoxide by ring-opening reaction with sodium thiolates and subsequent cleavage. The compounds were ineffective against herpes simplex virus type 1 and poliovirus. However, the cytotoxicity on murine tumour lines of 3,3-dimethyl lactone appeared to be promising.

A Convenient Synthesis of 2H-3,4-Dihydro-1,4-Benzothiazines

Abstract Aminothioalkenols react with paratoluenesulfonic acid in benzene or with phosphoric acid in toluene, and provide mainly heterocyclization in 2H-3,4-dihydro-1,4- benzothiazines; formation of some indenes and diene (in one case) was observed too.

Heterocyclisation of Unsaturated Phenylsulfides. Synthesis of a Novel Series of 2 Substituted-2,3-dihydrobenzothiazoles

Abstract Aminoarylhydroxy thioalkenes react with tosyl derivatives to provide mainly N substituted -2 vinyl -2,3 dihydrobenzothiazoles. A different regiochemistry of cyclization depending on whether a methyl or a phenyl susbtituent was used, was observed Formation of -2H-3,4-dihydrobenzothiazines and dienes was observed.