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Dive into the research topics where Arnaud Seigneurin is active.

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Featured researches published by Arnaud Seigneurin.


BMJ | 2011

Overdiagnosis from non-progressive cancer detected by screening mammography: stochastic simulation study with calibration to population based registry data

Arnaud Seigneurin; Olivier François; José Labarère; Pierre Oudeville; Jean Monlong; Marc Colonna

Objective To quantify the magnitude of overdiagnosis from non-progressive disease detected by screening mammography, after adjustment for the potential for lead time bias, secular trend in the underlying risk of breast cancer, and opportunistic screening. Design Approximate bayesian computation analysis with a stochastic simulation model designed to replicate standardised incidence rates of breast cancer. The model components included the lifetime probability of breast cancer, the natural course of breast cancer, and participation in organised and opportunistic mammography screening. Setting Isère, a French administrative region with nearly 1.2 million inhabitants. Participants All women living in Isère and aged 50-69 during 1991-2006. Main outcome measures Overdiagnosis, defined as the proportion of non-progressive cancers among all cases of invasive cancer and carcinoma in situ detected 1991-2006. Results In 1991-2006, overdiagnosis from non-progressive disease accounted for 1.5% of all cases of invasive cancer (95% credibility interval 0.3% to 2.9%) and 28.0% of all cases of carcinoma in situ (2.2% to 59.8%) detected either clinically or by screening mammography in Isère. When analysis was restricted to the cancers detected by screening mammography only, the estimates of overdiagnosis were 3.3% (0.7% to 6.5%) and 31.9% (2.9% to 62.3%) for invasive cancer and carcinomas in situ, respectively. Conclusion Overdiagnosis from the detection of non-progressive disease by screening mammography was limited in 1991-2006 in Isère. Because carcinoma in situ accounted for less than 15% of all incident breast cancer cases, its contribution to overdiagnosis was relatively limited and imprecise.


European Journal of Cancer Prevention | 2009

Incidence of second cancer within 5 years of diagnosis of a breast, prostate or colorectal cancer: a population-based study.

Camille Cluze; Patricia Delafosse; Arnaud Seigneurin; Marc Colonna

The objective of this study was to evaluate the risk for cancer patients of developing a new primary invasive cancer. Using data from a French Cancer Registry, we included 14 353 cancer patients (breast, colorectal or prostate cancer) diagnosed between 1989 and 1997. Observed second cancers occurring during the first 5 years after the first cancer were compared with the expected number, based on primary cancer incidence rate, by the standardized incidence ratio (SIR). Breast cancer patients had significantly elevated SIR for contralateral breast cancer (SIR=1.7), kidney cancer (SIR=3.5) and myeloid leukaemia (SIR=8.3). Patients diagnosed with colorectal cancer had significantly elevated risk for small intestine (SIR=10.7) and colorectal cancer (SIR=1.6). Young age at diagnosis of breast and colorectal cancers was associated with risk of a second cancer. After prostate cancer, men had no greater risk of cancer, except for kidney cancer. Our results help to direct attention to regions especially vulnerable to secondary cancers after primary breast or colorectal cancer.


Emergency Medicine Journal | 2014

Experience feedback committee in emergency medicine: a tool for security management

André Lecoanet; Elodie Sellier; Françoise Carpentier; Maxime Maignan; Arnaud Seigneurin; Patrice François

Objective Emergency departments are high-risk structures. The objective was to analyse the functioning of an experience feedback committee (EFC), a security management tool for the analysis of incidents in a medical department. Methods We conducted a descriptive study based on the analysis of the written documents produced by the EFC between November 2009 and May 2012. We performed a double analysis of all incident reports, meeting minutes and analysis reports. Results During the study period, there were 22 meetings attended by 15 professionals. 471 reported incidents were transmitted to the EFC. Most of them (95%) had no consequence for the patients. Only one reported incident led to the patients death. 12 incidents were analysed thoroughly and the committee decided to set up 14 corrective actions, including eight guideline writing actions, two staff trainings, two resource materials provisions and two organisational changes. Conclusions The staff took part actively in the EFC. Following the analysis of incidents, the EFC was able to set up actions at the departmental level. Thus, an EFC seems to be an appropriate security management tool for an emergency department.


Journal of Pharmaceutical Care & Health Systems | 2014

An Experience Feedback Committee for Improving Medication Process Safety: An Observational Study in a Hospital Pharmacy Department

Alban Caporossi; Etienne Brudieu; Audrey Lehmann; Arnaud Seigneurin; Patrice Francois

Study objective: An experience feedback committee (EFC) is a management method for patient safety designed for a medical team. The aim of this study was to analyse the functioning of an EFC in a hospital pharmacy department and to explore its contribution to medication process safety. Design: We conducted a transversal, observational study based on the analysis of all the written documents produced by the EFC between January 2012 and December 2013. Setting: The study was conducted in the pharmacy department at Grenoble University Hospital in France. Measurements: We analysed all the documents related to incidents reported, the reports of meetings and the reports of event analysis. Patient outcomes (degree of harm) were assessed according to the Conceptual Framework for the International Classification for Patient Safety. The main outcome was the corrective actions decided by the EFC. Main Results: During the study period, there were 22 meetings attended by a total of 59 professionals including seven pharmacists. A total of 320 incidents were analysed. Most of them (92%) had no medical consequence for the patient. Twenty-two incidents were selected to be thoroughly analysed. One hundred and ten corrective actions were carried out including 32 training sessions, 32 guidelines written, 32 changes in organisation, nine changes in equipment and five changes in another category. Conclusions: The EFC is an attractive method to involve healthcare professionals in quality and safety management.


Clinics and Research in Hepatology and Gastroenterology | 2014

Sensitivity of a colorectal cancer screening program based on a guaiac test: A population-based study

Joris Giai; Catherine Exbrayat; Bastien Boussat; Florence Poncet; Patrice Bureau Du Colombier; Marc Colonna; Arnaud Seigneurin

BACKGROUND The main objective of this study was to estimate the sensitivity of a colorectal cancer-screening program based on a guaiac fecal occult blood (FOB) test. The secondary objective was to determine whether the sensitivity varied by sex and if the difference between males and females could be explained by differences in age group at the time of the test, round of screening, how the test was provided to the participant, tumor location, and the presence of theoretical screening program exclusion criteria. METHODS For the 2002-2006 period, we retrospectively analyzed data from the organized colorectal screening program in Isère, France, which was designed for asymptomatic individuals aged 50-74. Sensitivity was assessed considering the number of interval cancers diagnosed in the 2 years following the test. A logistical regression analysis was done to evaluate the factors associated with the sensitivity of the screening program. RESULTS A total of 506 participants were included in the analysis. The overall sensitivity of the screening program was 48.4%, being 58.3% for males and 32.5% for females. In multivariate analysis, sensitivity for males was still higher than for females (OR=2.1 [95% CI, 1.4-3.4]) after adjusting for age group, presence of exclusion criteria, the way the test was given, the round of participation, and the tumor location. A total of 183 (36.2%) study subjects presented with at least one exclusion criterion for the screening program. CONCLUSION The sensitivity of the colorectal cancer-screening program based on a guaiac test was insufficient, being higher for males than for females. This difference in sensitivity was not entirely explained by differences in age, characteristics of screening participation, and tumor location.


The Breast | 2008

Artefact-free trends in breast cancer incidence over two decades in a whole French Département

Arnaud Seigneurin; Marc Colonna; Laurent Remontet; Patricia Delafosse; René Ecochard

The objective was to discuss the evolution of the real incidence of breast cancer. Observed incidence as calculated by cancer registries differs from the real incidence because of the artifacts brought by diagnostic procedures and case collection. Age-period-cohort models were applied to nearly 11,200 incident breast cancers collected by the Cancer Registry of Isère from 1983 to 2002 in women aged 30-84. We took into account prior knowledge and assumptions concerning the evolution of real incidence, diagnostic procedures, and collection of cases. In the age group 30-49, no real incidence increase was seen if we assume that diagnostic procedures and collection of cases were not impaired. In women aged 50-69, an increase of real incidence and intensive screening could explain the increase of observed incidence but exact quantifications are difficult. At most, the increase due to screening would reach 50%. In women aged 70-84, no real incidence increase was suspected if we assume that changes in clinical practices and screening led to more breast cancer cases collected.


Cancer Epidemiology | 2018

Incidence of prostate cancer and net survival by grade in a geriatric population: A population-based study in a French administrative entity from 1991 to 2013

Alexandre Bellier; Marc Colonna; Patricia Delafosse; Arnaud Seigneurin

BACKGROUND Prostate cancer is the leading type of cancer among men in more developed countries. Incidence trends and survival rates could differ by age groups considering potential differences in the frequency of PSA testing, types of cancers and medical management. Our objective was to compare incidence trends and survival rates of prostate cancer between men aged ≥75 and 60-74 years. METHOD We analyzed data from a population-based cancer registry in Isère, France. All men aged ≥60 years diagnosed with an incident prostate cancer during the 1991-2013 period were included. Incidence and mortality rates were computed as well as net survival rates. RESULTS In 2013, observed incidence rates were 557.6 and 568.7 per 100,000 for men aged 60-74 and ≥75, respectively, with high grades cancers more frequent among elderly men. The incidence and mortality trends among men aged ≥75 included a period of stability followed by a decreasing trend from 2003, whereas a peak of incidence was observed in 2005 for men aged 60-74. For both age groups, net survival rates increased with period of diagnosis and 8-year net survival remained higher than 70% for cases diagnosed in the 2000-2004 period. Lower survival rate of 51% (95%CI: 42%; 60%) was observed for high grades cancers diagnosed among men aged 75-84 in 2000-2004. CONCLUSION The epidemiology of prostate cancers among men aged ≥75 include a decrease of incidence and mortality rates from 2003, an important proportion of high grade cancers and a relatively good prognosis except for high grade cancers.


PLOS ONE | 2018

Experience feedback committees: A way of implementing a root cause analysis practice in hospital medical departments

Patrice Francois; André Lecoanet; Alban Caporossi; Anne-Marie Dols; Arnaud Seigneurin; Bastien Boussat

Background The experience feedback committee (EFC) is a tool designed to involve medical teams in patient safety management, through root cause analysis (RCA) within the team. Objectives To investigate the functioning of EFCs in the departments of a large university-affiliated hospital in France and to consider its potential contribution to the management of patient safety. Methods Cross-sectional, observational study, based on an analysis of the documents produced by the EFCs for 1 year. Data were collected independently by two investigators in meeting minutes, adverse event reports and event analysis reports. Results The study included all 20 EFCs operating in the hospitals medical departments. During the study year, committees held 164 meetings, reviewed 1707 adverse events, conducted 91 event analyses and decided on 206 corrective actions. The median number of corrective actions adopted by each EFC was five actions (range, 0–62). A root cause analysis (RCA) was present in 76% of the analysis reports, and these analyses were complete in only 23% of the reports. There was also a lack of planning corrective actions: an implementation deadline was only defined in 26% of the actions. Conclusions Healthcare professionals adhered to the system-based approach to patient safety, but we observed difficulties in holding regular meetings and deviations from the theoretical framework. These findings confirm the difficulties of practicing RCA in the healthcare setting. Nevertheless, EFCs can be vectors of safety culture and teamwork.


Clinics and Research in Hepatology and Gastroenterology | 2013

Determinants of participation in organized colorectal cancer screening in Isère (France)

Florence Poncet; Patricia Delafosse; Arnaud Seigneurin; Catherine Exbrayat; Marc Colonna


BMC Health Services Research | 2016

Assessment of the contribution of morbidity and mortality conferences to quality and safety improvement: a survey of participants’ perceptions

André Lecoanet; Gwenaëlle Vidal-Trecan; Frédéric Prate; Jean-François Quaranta; Elodie Sellier; Alizé Guyomard; Arnaud Seigneurin; Patrice François

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Marc Colonna

Centre Hospitalier Universitaire de Grenoble

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Patricia Delafosse

Centre Hospitalier Universitaire de Grenoble

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Elodie Sellier

Centre national de la recherche scientifique

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Joris Giai

Centre national de la recherche scientifique

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Florence Poncet

Centre Hospitalier Universitaire de Grenoble

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Patrice François

Centre national de la recherche scientifique

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