Arne Nergårdh
Karolinska University Hospital
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Publication
Featured researches published by Arne Nergårdh.
Scandinavian Journal of Urology and Nephrology | 1972
Arne Nergårdh; Lars Olof Boréus
Autonomic receptor function was studied in vitro in smooth muscle strips from the lower urinary tract of children and cats. In strips from the dome of the bladder, cholinergic and β-adrenergic, but no α-adrenergic receptor function was demonstrated. In the bladder base as well as in the proximal urethra cholinergic and both α- and β-adrenergic receptors were found. This suggests that the sympathetic nervous system can subserve relaxation in the dome of the bladder and both contraction and relaxation in the bladder base as well as in the proximal urethra.
Epilepsia | 1998
Ann-Sofie Eriksson; Arne Nergårdh; Kalle Hoppu
Summary: Purpose: We report a double‐blind, placebo‐controlled crossover study of lamotrigine (LTG) as add‐on treatment in therapy‐resistant, generalized epilepsy in children and adolescents (n = 30).
Epilepsia | 1996
Ann-Sofie Eriksson; Kalle Hoppu; Arne Nergårdh; Lars Olof Boréus
Summary: Purpose: We wished to determine the oral pharmacokinetics of lamotrigine LTG and to assess possible interactions with other AEDs in an unselected population of children. Concentration data in plasma and in CSF for lamotrigine as well as for the other AEDs are presented.
Epilepsia | 2003
Ann-Sofie Eriksson; Knutsson E; Arne Nergårdh
Summary: Purpose: In a double‐blind crossover study with lamotrigine (LTG), we investigated a possible relationship between the clinical responses and changes of the amount of epileptiform activity in EEG.
Scandinavian Journal of Urology and Nephrology | 1974
Arne Nergårdh
Adrencrgic receptor function has been studied in an in vitro preparation of bladder base, bladder neck and proximal urethra, i.e. in the outlet region. In this experimental sysiem changes in resistance to flow and isometric tension in longitudinal musculature could be recorded simultaneously when the preparation was continuously perfused at constant flow rate. It was found that the outflow region had a basal resistance to flow. Alpha-adrcnergic stimulation with metaoxedrine increased while beta-adrenergic stimulation with isoprenaline decreased flow resistance from this basic level. The beta-adrenergic reacticn was far more sensitive than the alpha-adrenergic one and was of longer duration. Similar results were obtained when adrenergic receptor function in the outflow region was studied in vivo in cats: it was then possible to activate and block the adrenergic receptors by the local application of drugs.
Scandinavian Journal of Urology and Nephrology | 1981
Anna-Stina Naglo; Arne Nergårdh; Lars Olof Boréus
Bladder hyperactivity defined as unconscious, involuntary detrusor contractions giving rise to intravesical pressure increase of at least 15 cm H2O and of minimum 15 sec duration, has been examined in 9 children with myelodysplasia and incontinence. The effect of atropine and isoprenaline on the hyperactivity pattern was evaluated. Atropine had a dose-related inhibiting influence on both frequency and amplitude of detrusor contractions whereas isoprenaline was without these favourable effects.
Scandinavian Journal of Urology and Nephrology | 1974
Arne Nergårdh
The interaction between cholinergic and adrenergic receptor functions in the outlet region has been studied in vitro on preparations from cat bladder. Variations in resistance to perfusion were recorded, together with changes in the tension in longitudinal musculature. If the outlet region was contracted by continuous perfusion with alphn-adrenergic drugs it could be relaxed completely by intermittent beta-adrenergic stimulation. Cholinergic stimulation with acetylcholine also had a relaxing effect in this situation. On the other hand, if the outlet region was continuously relaxed with a beta-adrenergic stimulating drug, the flow resistance could be increased by alpha-adrenergic induced muscle activity and also by acelylcholine. Thus the adrenergic receptor functions appear to antagonize each other in the internal sphincter region, which is particularly sensitive to beta stimulation. The dual action of acetylcholine on flow resistance is probably due to its effect on the circular musculalure is mediated b...
Scandinavian Journal of Urology and Nephrology | 1983
Arne Nergårdh; Anne-Charlotte Kinn
The endogenous contracting transmitter at the neuromuscular junction in strips from human urinary bladder has been investigated using field stimulation and selective antagonists. Atropine in low concentrations was found to inhibit bladder contractions whereas higher concentrations of the drug sometimes had the opposite effects. Indomethacin inhibited, phentolamine enhanced and methysergide had no dose-dependent effect on the field stimulation response. It is proposed that acetylcholine is one of the transmitter substances responsible for the contraction of the human detrusor. Species differences which could be responsible for the alleged atropine-resistance of the bladder are discussed. It is concluded that anticholinergic drugs should be of therapeutic value for treatment of muscular hyperactivity in the human urinary bladder.
Scandinavian Journal of Urology and Nephrology | 1981
Anna-Stina Naglo; Arne Nergårdh
Detrusor hyperactivity and its reproducibility was investigated in 22 patients with myelodysplasia and neurogenic bladder. The examinations were performed with microtransducers in the bladder, proximal urethra and rectum. Hyperactivity was found in 15 children all belonging to low lumbar and sacral neurological lesion groups. Patients without hyperactivity mostly had their levels of lesion higher in the spinal cord. In 6 children without neurologic disease no hyperactivity was found.
Epilepsia | 2000
Maria Dahlin; Evert Knutsson; Per Åmark; Arne Nergårdh
Summary: Purpose: To evaluate the effect of low‐dose clonazepam (CZP) on the amount of epileptiform activity in children with focal and generalized epilepsy.