Arnold E. Andersen

Delayed gastrointestinal transit times in anorexia nervosa and bulimia nervosa

Anorectic and bulimic patients frequently report symptoms of constipation, bloating, and abdominal pain suggestive of abnormal gastrointestinal motility or transit. However, except for studies of gastric emptying, gastrointestinal motility and transit in these eating disorders have not been investigated. Ten anorectic and 18 bulimic inpatients were compared with 10 healthy controls. Whole-gut transit was tested by the radiopaque marker technique, and mouth-to-cecum transit time was assessed by the lactulose breath test. All anorectics and 67% of bulimics complained of constipation. Whole-gut transit time was significantly delayed in both anorectics (66.6 +/- 29.6 hours) and bulimics (70.2 +/- 32.4 hours) compared with controls (38.0 +/- 19.6 hours). Mouth-to-cecum transit time also tended to be longer in anorectics (109.0 +/- 33.5 minutes) and bulimics (106.2 +/- 24.5 minutes) than in controls (84.0 +/- 27.7 minutes), but these differences were not statistically significant. Delayed transit could contribute to or perpetuate the eating disorders by (a) causing the patient to feel bloated, thereby exacerbating fear of fatness, or (b) causing rectal distention, which may reflexly inhibit gastric emptying.

A SLIMMING PROGRAM FOR EATING DISORDERS NOT OTHERWISE SPECIFIED: Reconceptualizing a Confusing, Residual Diagnostic Category

This study suggests that the category of EDNOS as currently defined is overly broad, representing many cases that could be more helpfully subsumed within AN or BN diagnostic criteria without changing the essential features of these categories but by rethinking the currently overly restrictive, perhaps research-derived criteria. The reconceptualizing of AN as a syndrome resulting from a decrement between setpoint versus illness-driven final weight avoids the inherent problems of imposing a category on a dimension. A rethinking of AN suggests that a specific female-only abnormality of reproductive hormone functioning, 3 months of amenorrhea, is too restrictive. Instead, a more encompassing criterion recognizing the multiple medical, social, and psychologic functional impairments that result from substantial starvation would be appropriate in its place. Clinicians who otherwise confidently treat AN and BN patients would welcome the clearer diagnostic categorization of the potentially confusing EDNOS category. Third party payers who currently, albeit wrongly, exclude EDNOS diagnoses from insurance payment, would have less difficulty with a smaller group of EDNOS. In summary, the currently overly broad category of EDNOS as currently used would benefit from a thoughtful dieting regimen.

Bipolar II affective disorder in eating disorder inpatients

We examined the association between affective disorders and eating disorders in 22 eating disorder inpatients who were interviewed using the Schedule for Affective Disorders and Schizophrenia-Lifetime Version. The first series of 11 were interviewed as part of an interrater reliability study; the second series, done as follow-up to the first, consisted of 11 consecutive admissions. Overall, there were 15 bulimics and seven anorexics. Nineteen patients had a major affective disorder, and 13 (59%) had bipolar II affective disorder. Bipolar II affective disorder appears to be a common finding in hospitalized patients with severe persistent eating disorders.

Neuropsychological characteristics of patients in a hospital-based eating disorder program

The existence of cognitive deficits associated with eating disorders has been debated for some time. The present study investigated cognitive impairments in a large sample of patients with anorexia nervosa from an inpatient treatment program. Fifty-nine women with anorexia nervosa were given a battery of neuropsychological tests assessing multiple cognitive domains. Over half of the patients had mild cognitive impairments in two or more neuropsychological tasks and approximately one-third failed two or more tasks. Depression level and body mass were not associated with cognitive impairment. Whether effective restoration of weight and resolution of core psychopathology contribute to reversal of cognitive deficits requires further research.

Effects of acute food deprivation on eating behavior in eating disorders.

OBJECTIVE Effects of acute food deprivation on eating behavior in bulimic patients and controls were investigated. It was predicted that food deprivation would increase overall food intake and result in overeating in bulimics. METHOD Following 19 hr of food deprivation (in which breakfast and lunch were skipped), or no deprivation, food intake was measured in 9 inpatients with anorexia nervosa (binge eating/purging subtype, ANB), 10 inpatient (BN/in) and 9 outpatient (BN/out) normal-weight bulimics, and 11 unrestrained and 10 restrained controls. RESULTS A general trend for increased food intake following deprivation was found. However, only BN/in patients consumed significantly more and selected higher energy foods following deprivation. ANB patients demonstrated the greatest degree of variability in intake and the least magnitude of change in ratings as a function of eating. DISCUSSION A period of acute food deprivation did not trigger marked eating pathology as evidenced by overconsumption. Chronic dietary restraint may be a more potent precipitating factor in overeating than absolute number of hours of food restriction.

Eating disorders in the obstetric and gynecologic patient population

The eating disorders anorexia nervosa and bulimia nervosa and eating disorders not otherwise specified disproportionately affect women, have profound effects on the overall well-being of women and their children, and can have mortality rates as high as those found with major depression. These disorders may present to obstetrician-gynecologists (ob-gyns) clinically as menstrual dysfunction, low bone density, sexual dysfunction, miscarriage, preterm delivery, or low birth weight in offspring. Ninety percent of eating disorders develop before the age of 25 in otherwise healthy young women, a group that characteristically seeks the majority of their health care from ob-gyns. For all of these reasons, ob-gyns must have a greater awareness of these disorders and a lower index of suspicion for screening their patients than they currently do. Otherwise, they may miss life-threatening illness, treat characteristic amenorrhea inappropriately, or inadvertently intervene to help these women conceive, contributing to maternal and fetal risks. As providers of both primary and specialty care for women, ob-gyns have the opportunity to play a vital role in prevention and diagnosis of eating disorders and in the multidisciplinary management required to effectively manage these disorders.

High Risk of Osteoporosis in Male Patients with Eating Disorders

OBJECTIVE Osteoporosis has traditionally been considered a female problem. This studys purpose is to evaluate bone mineral density (BMD) in males with eating disorders. METHOD Charts of 70 consecutive males admitted to an eating disorder program were reviewed. Females admitted during the same time period were used for comparison. BMD was measured by dual-energy X-ray absorptiometry. RESULTS Thirty-six percent (19/53) had osteopenia and 26% (14/53) had osteoporosis at the lumbar spine. A disproportionate number of males with anorexia restricting or binge/purge subtype (ANR/ANB) had osteoporosis, as well as those of older age, lower weights, and longer illness duration. BMD for ANR and ANB males was significantly lower than females (p = .02 and p = .03, respectively). In multivariate stepwise linear and logistic regression, lowest BMI and illness duration predicted lumbar Z-scores. CONCLUSION Males with ANR/ANB often have severe bone disease, which is worse than females, and is best predicted by a patients lowest BMI and illness duration.

Truly late onset of eating disorders : A study of 11 cases averaging 60 years of Age at presentation

OBJECTIVE To study late-onset cases of eating disorders in order to (1) document the occurrence of these cases as truly new onset, even if postmenopausal; (2) to alert clinicians to the category of late-onset eating disorders, especially clinical features and treatment response; (3) to challenge some prevailing assumptions of etiology. METHODS Selection of cases of eating disorders with first onset after age 40 that met DSM-IV criteria, by review of eating disorders admissions to three university hospital programs. RESULTS Eleven patients, approximately 1% of all cases of eating disorders, had first onset of an eating disorder after age 40 and as late as 77, with an average onset of 56 and clinical presentation at 60 years. They met DSM-IV criteria for all subtypes of eating disorders. In general, concurrent medical and comorbid psychiatric symptoms made recognition and treatment more complex. DISCUSSION Truly late-onset cases do occur, challenging etiological theories requiring adolescent age of onset, premenopausal endocrine functioning, or adolescent psychodynamic conflicts. Late-occurring cases, after accurate diagnosis, require an appreciation of psychological themes pertinent to this age group, such as bereavement or unresolved body image issues. Age by itself is no barrier to onset of eating disorders, which may occur whenever self-starvation and/or binge-purge behaviors become entrenched as sustaining behaviors for amelioration of psychodynamic conflicts, mood disorders, or interpersonal distress.

Eating disorders : Guide to medical evaluation and complications

Eating disorders lead to numerous physical complaints with signs and symptoms affecting nearly every organ system of the body. We review the presentation of a patient with eating disorder to the primary care giver or general psychiatrist, focusing on the physical manifestations of the underlying illness. Specific complications related to laboratory findings, the gastrointestinal tract, and the endocrine system are reviewed. Algorithms for medical evaluation of these patients are also presented.

Osteoporosis and osteopenia in men with eating disorders

The occurrence of eating disorders and related deficiencies in bone mineral density are well established in women. However, we provide evidence that eating disorders are as common in men as in women, and are perhaps more severe.