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Dive into the research topics where Arseny Finkelstein is active.

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Featured researches published by Arseny Finkelstein.


Nature | 2015

Three-dimensional head-direction coding in the bat brain

Arseny Finkelstein; Dori Derdikman; Alon Rubin; Jakob N. Foerster; Liora Las; Nachum Ulanovsky

Navigation requires a sense of direction (‘compass’), which in mammals is thought to be provided by head-direction cells, neurons that discharge when the animal’s head points to a specific azimuth. However, it remains unclear whether a three-dimensional (3D) compass exists in the brain. Here we conducted neural recordings in bats, mammals well-adapted to 3D spatial behaviours, and found head-direction cells tuned to azimuth, pitch or roll, or to conjunctive combinations of 3D angles, in both crawling and flying bats. Head-direction cells were organized along a functional–anatomical gradient in the presubiculum, transitioning from 2D to 3D representations. In inverted bats, the azimuth-tuning of neurons shifted by 180°, suggesting that 3D head direction is represented in azimuth × pitch toroidal coordinates. Consistent with our toroidal model, pitch-cell tuning was unimodal, circular, and continuous within the available 360° of pitch. Taken together, these results demonstrate a 3D head-direction mechanism in mammals, which could support navigation in 3D space.


Stroke | 2007

A Novel Immune-Based Therapy for Stroke Induces Neuroprotection and Supports Neurogenesis

Yaniv Ziv; Arseny Finkelstein; Yona Geffen; Jonathan Kipnis; Igor Smirnov; Suzi Shpilman; Irena Vertkin; Michal Kimron; Aya Lange; Torsten Hecht; Klaus G. Reyman; Jonathan B. Marder; Michal Schwartz; Eti Yoles

The ability of the central nervous system to cope with stressful conditions was shown to be dependent on proper T-cell–mediated immune response. Because the therapeutic window for neuroprotection after acute insults such as stroke is relatively narrow, we searched for a procedure that would allow the relevant T cells to be recruited rapidly. Permanent middle cerebral artery occlusion was induced in adult rats. To facilitate a rapid poststroke T cell activity, rats were treated with poly-YE using different regimens. Control and poly-YE–treated rats were assessed for functional recovery using neurological severity score and Morris water maze. Neuroprotection, neurogenesis, growth factor expression, and microglial phenotype were assessed using histological and immunofluorescence methods. Administration of poly-YE as late as 24 hours after middle cerebral artery occlusion yielded a beneficial effect manifested by better neurological performance, reduced neuronal loss, attenuation of behavioral deficits, and increased hippocampal and cortical neurogenesis. This compound affected the subacute phase by modulating microglial response and by increasing local production of insulin-like growth factor-I, known to be a key player in neuronal survival and neurogenesis. The relative wide therapeutic window, coupled with its efficacy in attenuating further degeneration and enhancing restoration, makes poly-YE a promising immune-based candidate for stroke therapy.


PLOS ONE | 2011

Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS

Arseny Finkelstein; Gilad Kunis; Akop Seksenyan; Ayal Ronen; Tamara Berkutzki; David Azoulay; Maya Koronyo-Hamaoui; Michal Schwartz

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing fatal neurodegenerative disorder characterized by the selective death of motor neurons (MN) in the spinal cord, and is associated with local neuroinflammation. Circulating CD4+ T cells are required for controlling the local detrimental inflammation in neurodegenerative diseases, and for supporting neuronal survival, including that of MN. T-cell deficiency increases neuronal loss, while boosting T cell levels reduces it. Here, we show that in the mutant superoxide dismutase 1 G93A (mSOD1) mouse model of ALS, the levels of natural killer T (NKT) cells increased dramatically, and T-cell distribution was altered both in lymphoid organs and in the spinal cord relative to wild-type mice. The most significant elevation of NKT cells was observed in the liver, concomitant with organ atrophy. Hepatic expression levels of insulin-like growth factor (IGF)-1 decreased, while the expression of IGF binding protein (IGFBP)-1 was augmented by more than 20-fold in mSOD1 mice relative to wild-type animals. Moreover, hepatic lymphocytes of pre-symptomatic mSOD1 mice were found to secrete significantly higher levels of cytokines when stimulated with an NKT ligand, ex-vivo. Immunomodulation of NKT cells using an analogue of α-galactosyl ceramide (α-GalCer), in a specific regimen, diminished the number of these cells in the periphery, and induced recruitment of T cells into the affected spinal cord, leading to a modest but significant prolongation of life span of mSOD1 mice. These results identify NKT cells as potential players in ALS, and the liver as an additional site of major pathology in this disease, thereby emphasizing that ALS is not only a non-cell autonomous, but a non-tissue autonomous disease, as well. Moreover, the results suggest potential new therapeutic targets such as the liver for immunomodulatory intervention for modifying the disease, in addition to MN-based neuroprotection and systemic treatments aimed at reducing oxidative stress.


Science | 2017

Vectorial representation of spatial goals in the hippocampus of bats

Ayelet Sarel; Arseny Finkelstein; Liora Las; Nachum Ulanovsky

How to get to place B We constantly navigate around our environment. This means moving from our current location, place A, to a new goal, place B. We have recently learned much about spatial maps in the brain in which place cells indicate current location. However, it is unclear how navigational goals are represented in the brain. Sarel et al. describe a group of neurons in the brains of bats that are tuned to goal direction and distance relative to the bats current position as it flies toward its goal. The finding elucidates the computations involved in spatial navigation. Science, this issue p. 176 A subpopulation of neurons in the bat hippocampus indicate distance and direction to the location of a goal. To navigate, animals need to represent not only their own position and orientation, but also the location of their goal. Neural representations of an animal’s own position and orientation have been extensively studied. However, it is unknown how navigational goals are encoded in the brain. We recorded from hippocampal CA1 neurons of bats flying in complex trajectories toward a spatial goal. We discovered a subpopulation of neurons with angular tuning to the goal direction. Many of these neurons were tuned to an occluded goal, suggesting that goal-direction representation is memory-based. We also found cells that encoded the distance to the goal, often in conjunction with goal direction. The goal-direction and goal-distance signals make up a vectorial representation of spatial goals, suggesting a previously unrecognized neuronal mechanism for goal-directed navigation.


Neurotoxicity Research | 2013

The Role of Glutamate and the Immune System in Organophosphate-induced CNS Damage

Arik Eisenkraft; Avshalom Falk; Arseny Finkelstein

Organophosphate (OP) poisoning is associated with long-lasting neurological damage, which is attributed mainly to the excessive levels of glutamate caused by the intoxication. Glutamate toxicity, however, is not specific to OP poisoning, and is linked to propagation of damage in both acute and chronic neurodegenerative conditions in the central nervous system (CNS). In addition to acute excitotoxic effects of glutamate, there is now a growing amount of evidence of its intricate immunomodulatory effects in the brain, involving both the innate and the adaptive immune systems. Moreover, it was demonstrated that immunomodulatory treatments, aimed at regulating the interaction between the resident immune cells of the brain (microglia) and the peripheral immune system, can support buffering of excessive levels of glutamate and restoration of the homeostasis. In this review, we will discuss the role of glutamate as an excitotoxic agent in the acute phase of OP poisoning, and the possible functions it may have as both a neuroprotectant and an immunomodulator in the sub-acute and chronic phases of OP poisoning. In addition, we will describe the novel immune-based neuroprotective strategies aimed at counteracting the long-term neurodegenerative effects of glutamate in the CNS.


Annual Review of Neuroscience | 2016

3-D Maps and Compasses in the Brain

Arseny Finkelstein; Liora Las; Nachum Ulanovsky

The world has a complex, three-dimensional (3-D) spatial structure, but until recently the neural representation of space was studied primarily in planar horizontal environments. Here we review the emerging literature on allocentric spatial representations in 3-D and discuss the relations between 3-D spatial perception and the underlying neural codes. We suggest that the statistics of movements through space determine the topology and the dimensionality of the neural representation, across species and different behavioral modes. We argue that hippocampal place-cell maps are metric in all three dimensions, and might be composed of 2-D and 3-D fragments that are stitched together into a global 3-D metric representation via the 3-D head-direction cells. Finally, we propose that the hippocampal formation might implement a neural analogue of a Kalman filter, a standard engineering algorithm used for 3-D navigation.


Brain Behavior and Immunity | 2012

Immunomodulation by poly-YE reduces organophosphate-induced brain damage

Arseny Finkelstein; Gilad Kunis; Tamara Berkutzki; Ayal Ronen; Amir Krivoy; Eti Yoles; Yael Mardor; Kerry Van Shura; Emylee McFarland; Benedict A. Capacio; Claire G Eisner; Mary D. Gonzales; Danise Gregorowicz; Arik Eisenkraft; John H. McDonough; Michal Schwartz

Accidental organophosphate poisoning resulting from environmental or occupational exposure, as well as the deliberate use of nerve agents on the battlefield or by terrorists, remain major threats for multi-casualty events, with no effective therapies yet available. Even transient exposure to organophosphorous compounds may lead to brain damage associated with microglial activation and to long-lasting neurological and psychological deficits. Regulation of the microglial response by adaptive immunity was previously shown to reduce the consequences of acute insult to the central nervous system (CNS). Here, we tested whether an immunization-based treatment that affects the properties of T regulatory cells (Tregs) can reduce brain damage following organophosphate intoxication, as a supplement to the standard antidotal protocol. Rats were intoxicated by acute exposure to the nerve agent soman, or the organophosphate pesticide, paraoxon, and after 24 h were treated with the immunomodulator, poly-YE. A single injection of poly-YE resulted in a significant increase in neuronal survival and tissue preservation. The beneficial effect of poly-YE treatment was associated with specific recruitment of CD4(+) T cells into the brain, reduced microglial activation, and an increase in the levels of brain derived neurotrophic factor (BDNF) in the piriform cortex. These results suggest therapeutic intervention with poly-YE as an immunomodulatory supplementary approach against consequences of organophosphate-induced brain damage.


Israel Medical Association Journal | 2005

Pharmacologic prophylaxis against nerve agent poisoning.

Ida Layish; Amir Krivoy; Eran Rotman; Arseny Finkelstein; Zeev Tashma; Yoav Yehezkelli


Harefuah | 2005

[Political poisoning with dioxins--a weapon of chemical "disgracefulness"].

Arseny Finkelstein; Eran Rotman; Arik Eisenkraft; Amir Krivoy; Laish I; Zeev Tashma; Azik Hoffman; Yoav Yehezkelli


Military Medicine | 2007

Mobile chemical detector (AP2C+SP4E) as an aid for medical decision making in the battlefield.

Arik Eisenkraft; Gal Markel; Shirley Simovich; Ido Layish; Azik Hoffman; Arseny Finkelstein; Eran Rotman; Tsvika Dushnitsky; Amir Krivoy

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Arik Eisenkraft

United Kingdom Ministry of Defence

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Liora Las

Weizmann Institute of Science

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Nachum Ulanovsky

Weizmann Institute of Science

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Michal Schwartz

Weizmann Institute of Science

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Alon Rubin

Weizmann Institute of Science

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Ayal Ronen

Weizmann Institute of Science

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