Ashit K. Ganguly
Stevens Institute of Technology
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Featured researches published by Ashit K. Ganguly.
Tetrahedron Letters | 2002
Ashit K. Ganguly; N. Seah; V. Popov; C.H. Wang; Rongze Kuang; Anil K. Saksena; Birendra N. Pramanik; Tze-Ming Chan; Andrew T. McPhail
A convenient synthesis of enantiomerically pure oxindoles using a three component reaction involving 1:3 dipolar cycloaddition reaction has been achieved using solution and solid phase chemistry.
Journal of Medicinal Chemistry | 2011
Ashit K. Ganguly; S. Alluri; Danielle Caroccia; D. Biswas; C.H. Wang; Eunhee Kang; Yong Zhang; Andrew T. McPhail; Steven S. Carroll; Christine Burlein; Vandna Munshi; Peter Orth; Corey Strickland
In the present paper, design, synthesis, X-ray crystallographic analysis, and HIV-1 protease inhibitory activities of a novel class of compounds are disclosed. Compounds 28-30, 32, 35, and 40 were synthesized and found to be inhibitors of the HIV-1 protease. The crucial step in their synthesis involved an unusual endo radical cyclization process. Absolute stereochemistry of the three asymmetric centers in the above compounds have been established to be (4S,2R,3S) for optimal potency. X-ray crystallographic analysis has been used to determine the binding mode of the inhibitors to the HIV-1 protease.
Tetrahedron Letters | 2002
Ashit K. Ganguly; C.H. Wang; M. David; Peter L. Bartner; Tze-Ming Chan
A generalised radical reaction has been used to synthesise heterocyclic compounds which could serve as ligands for drug discovery. Attempt also have been made to rationalise the formation of oxidation products formed during TBTH reaction.
Tetrahedron Letters | 1995
Anil K. Saksena; Viyyoor M. Girijavallabhan; Raymond G. Lovey; Russell E. Pike; Haiyan Wang; Ashit K. Ganguly; Brian Morgan; Alexsey Zaks; Mohinder S. Puar
A convenient synthesis of (−)-(2R)-cis-tosylate 2 is reported via stereoselective 5-exo iodocyclization of the optically active 2,2-disubstituted olefin 9a. Enzymatic desymmetrization of the homoallylic diol 4 with Novo SP435 allowed optimal pro-(S) selectivity to provide the desired (−)-(S)-monoacetate 9a. Under the irreversible reaction conditions, the presence of a bulky aryl substituent on the 2,2-disubstituted olefin seems to determine stereochemical outcome of these halocyclizations.
Tetrahedron Letters | 2000
Rongze Kuang; Ashit K. Ganguly; Tze-Ming Chan; Birendra N. Pramanik; David J. Blythin; Andrew T. McPhail; Anil K. Saksena
Abstract The first enantioselective syntheses of carbocyclic ribavirin by both convergent and linear approaches are described. The linear approach from chiral nonracemic 2-azabicyclo[2.2.1]hept-5-en-3-one proves to be a highly efficient route to carbocyclic analogs of ribavirin.
Journal of The Chemical Society, Chemical Communications | 1989
Alan B. Cooper; John J. Wright; Ashit K. Ganguly; Jagdish A. Desai; David Loebenberg; Raulo Parmegiani; David S. Feingold; Inder Jit Sud
Several 14-α-aminomethyl-substituted lanosterol derivatives have been synthesized involving a complete Δ7,8to Δ8,9isomerization; these compounds are inhibitors of fungal ergosterol biosynthesis and are active against intact Candida and dermatophyte strains.
Journal of The Chemical Society, Chemical Communications | 1977
Ashit K. Ganguly; Olga Sarre; Andrew T. McPhail; Kay D. Onan
Single crystal X-ray analysis of the title compound (8) is reported which establishes the stereochemistry at C-3 of evernitrose.
Journal of The Chemical Society, Chemical Communications | 1974
Ashit K. Ganguly; Sol Szmulewicz; Olga Sarre; Dianne Greeves; James B. Morton; James McGlotten
The antibiotic halomicin B has been shown by spectroscopic and chemical means to have the structure (1).
Journal of The Chemical Society, Chemical Communications | 1973
Ashit K. Ganguly; Anil K. Saksena
Hydrolysis of everninomicin B yields a mixture from which a heptasaccharide, everheptose B, has been isolated; everheptose B contains a new sugar, D-evalose, the structure and absolute stereochemistry of which has been established.
Journal of The Chemical Society D: Chemical Communications | 1969
Ashit K. Ganguly; Olga Sarre
Evermicose, an hydrolysis product of everninomicin B and D, has been shown to be 3-C-methyl-2,6-dideoxy-D-arabinohexose, or D-3-epimycarose.