Ashok B. Vaidya

Galactorrhea and Parkinson-like syndrome: An adverse effect of α-methyldopa

Abstract Methyldopa induced galactorrhea and a Parkinson-like syndrome in a 15-year-old girl with chronic glomerulonephritis. On discontinuation of the drug, the adverse effects disappeared and did not recur. Dopamine and/or norepinephrine deficiency induced by methyldopa is proposed as a probable central mechanism for these adverse effects.

Hypothermia in a Patient with Carcinoid Syndrome during Treatment with Parachlorophenylalanine

PARA-CHLOROPHENYLALANINE (Fenclonine, PCP) is a drug that reduces levels of serotonin (5-hydroxytryptamine) in the tissues of animals and of man by inhibition of the rate-limiting enzyme in its bio...

Effects of Brocresine on Zollinger-Ellison Syndrome Report of 2 Cases

SummaryBrocresine, an inhibitor of histidine decarboxylase activity, was given to 2 patients with Zollinger-Ellison syndrome. In Patient 1, during a short period of study, there appeared to be a reduction in gastric acid secretion, manifested primarily by a decrease in the volume of secretion. In Patient 2, during a longer period of brocresine treatment, there was significant reduction in both concentration and output of acid but no significant change in the acid secretory response to administered histamine. These findings, though inconclusive, are consistent with the hypothesis that histamine may serve as the chemical mediator of the effect of gastrin on gastric acid secretion in man. In each patient there was marked relief of diarrhea which antedated any detectable effect of brocresine on gastric acid secretion. This finding was not anticipated and its mechanism is unexplained. It suggests that in patients with Zollinger-Ellison syndrome, diarrhea may occur as a result of factors other than gastric acid hypersecretion.

Effects of anticholinergic drugs on Zollinger-Ellison syndrome

SummaryAnticholinergic drugs in a patient with Z-E syndrome were only temporarily successful in suppressing gastric hypersecretion and producing symptomatic relief. After escape from control with propantheline bromide, glycopyrrolate was only partially successful in suppressing basal acid secretion. Eventually, complete escape from anticholinergic control occurred with a recurrence of significant gastric hypersecretion and the development of severe peptic esophagitis, necessitating total gastrectomy.

Failure of epinephrine to provoke flushing in patients with systemic mastocytosis.

Abstract The epinephrine provocative test was performed in five patients in whom the diagnosis of systemic mastocytosis had been established both by biopsy and by findings of high histamine levels ...