Ashutosh V. Bedekar

Clay catalyzed chemoselective Michael type addition of aliphatic amines to α,β-ethylenic compounds

Abstract Application of acidic clays as heterogeneous catalysts for the Michael type addition reaction of aliphatic amines to α,β-ethylenic compounds is presented. Aromatic amines do not participate in this transformation.

SIMPLE AND PRACTICAL HALOGENATION OF ARENES, ALKENES AND ALKYNES WITH HYDROHALIC ACID/H2O2 (OR TBHP)

Abstract A simple protocol for the halogenation of arenes utilizing a combination of aqueous hydrogen peroxide (34 %) or tert-butylhydroperoxide (70 %) and hydrohalic acid is presented. A similar procedure of oxyhalogenation involving the in situ generation of positive halogen reagents is applied for the preparation of vicinal trans-dibromoalkanes and dichloroalkanes from alkenes. The reaction of alkenes with a combination of hydrochloric acid and hydrobromic acid with hydrogen peroxide gave a mixture of 1-bromo 2-chloro alkanes and 1,2-dibromoalkanes. Oxidative bromination of alkynes is also reported under similar conditions.

SIMPLE AND EFFICIENT CHLORINATION AND BROMINATION OF AROMATIC COMPOUNDS WITH AQUEOUS TBHP (OR H2O2) AND A HYDROHALIC ACID

A combination of aqueous tert-butylhydroperoxide (70%) or hydrogen peroxide (34%) and a hydrohalic acid was found effective in chlorination and bromination of aromatic compounds.

Natural Kaolinitic clay catalyzed conversion of nitriles to 2-oxazolines

Abstract Natural Kaolinitic clay has been found effective as catalyst in the conversion of aromatic and aliphatic nitriles with 1,2-aminoalcohol to 2-oxazolines (56 – 96 % yield).

Preparation and evaluation of nitrene precursors (PhI=NSO2Ar) for the copper-catalyzed aziridination of olefins

The preparation of different [N-(arenesulfonyl)imino]phenyliodinanes is described along with an evaluation of their utility as nitrene precursors for the copper-catalyzed aziridination of different ...

A new class of bis-oxazoline ligands for the Cu-catalysed asymmetric cyclopropanation of olefins

A New Class of Bis-Oxazoline Ligands for the Cu-Catalysed Asymmetric Cyclopropanation of Olefins

Bromamine-T: A superior source of nitrene for aziridination of olefins

Abstract Bromamine-T as a superior source of nitrene compared to Chloramine-T in the Cu-catalyzed aziridination of olefins is reported in this communication.

A mild procedure for the clay catalyzed selective removal of the tert-butoxycarbonyl protecting group from aromatic amines

Abstract The application of solid acidic catalysts for the selective removal of N-Boc protection is presented in this report. Montmorillonite K10 was found to be an effective catalyst in removing aromatic N-Boc groups while leaving aliphatic N-Boc amines untouched.

Microwave Assisted Preparation of Isatins and Synthesis of (±)-Convolutamydine-A

Abstract Microwave assisted preparation of a number of isatin derivatives is reported. A simple synthesis of (±)-convolutamydine-A, a potent compound against leukemia cells, is presented.

Studies on bromination of active methylene by a mixture of hydrobromic acid and hydrogen peroxide (or TBHP)

Abstract Studies on bromination of active methylene with a mixture of hydrogen peroxide or tert-butylhydroperoxide (TBHP) and hydrobromic acid are discussed. Substituted acetophenones, benzocyclic ketones provide α-bromo-keto compounds in high yields under this reaction condition.