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European Journal of Obstetrics & Gynecology and Reproductive Biology | 2010

Effects of pinealectomy and melatonin supplementation on endometrial explants in a rat model

Onder Koc; Bülent Gündüz; Ata Topcuoglu; Guler Bugdayci; Fahri Yilmaz; Bülent Duran

OBJECTIVE To determine the effects of pinealectomy on endometrial explants in rats and evaluate the activity of superoxide dismutase (SOD) and catalase (CAT) and the levels of malondialdehyde (MDA) in the rat endometriosis model. STUDY DESIGN Rats with experimentally induced endometriosis were randomly divided into three groups after second-look laparotomies. Group 1 (pinealectomy, n = 8) and Group 2 (pinealectomy+melatonin, n = 8) underwent pinealectomies after the second-look laparotomies. Group 3 was presented as control group (vehicle solution+without pinealectomy (n = 6)). Melatonin was administered intraperitoneally for 4 weeks in Group 2, whereas an equal volume of vehicle solution was given to Groups 1 and 3. Evaluation of the volume of the endometrial explants, histopathological examination and preservation of explant epitheliums according to the scoring system were undertaken. RESULTS There was a statistically significant increase in spherical explant volumes of Group 1 compared to Groups 2 and 3. In Group 1, the level of MDA was significantly higher and SOD and CAT activity was significantly lower compared to Groups 2 and 3. A statistically significant increase in the epithelial lining scores of explants was noted in Group 1 compared to Groups 2 and 3. CONCLUSION The effects of pinealectomy on the progression of endometriosis explants were reversed by melatonin.


European Journal of Obstetrics & Gynecology and Reproductive Biology | 2009

Intraperitoneal administration of single dose type I collagen or low dose melatonin to prevent intraperitoneal adhesion formation: A comparative study

Onder Koc; Bülent Duran; Ata Topcuoglu; Guler Bugdayci; Fahri Yilmaz; Melahat Emine Dönmez

OBJECTIVE To compare the prevention of adhesion formation by type I collagen or melatonin solutions in the rat model. STUDY DESIGN A total of 40 female Wistar albino rats were randomly assigned to four groups-type I collagen, melatonin, vehicle control and sham groups. Following midline laparotomy, a standard injury was made on the right uterine horn using bipolar cautery. The animals in the sham group underwent midline laparatomy only. One milliliter of type I collagen, melatonin or vehicle control was instilled onto the injured area immediately before abdominal closure. Fourteen days after the surgery, the type and extent of adhesion formation as well as the uterine horn tissue superoxide dismutase (SOD) and catalase (CAT) activity, and malondialdehyde (MDA) levels were measured. RESULTS Both the type and extent of adhesion formation were significantly lower in the type I collagen and melatonin groups compared to the control group. The tissue SOD and CAT activity was significantly higher, and MDA levels were significantly lower in the type I collagen and melatonin groups compared to the control group. CONCLUSION Intraperitoneal administration of type I collagen or low dose melatonin solution onto the injured areas may be an attractive adjuvant to reduce postoperative adhesion formation.


Current Therapeutic Research-clinical and Experimental | 2011

In Vivo Evaluation of the Genotoxic Effects of Gonadotropins on Rat Reticulocytes

Bülent Duran; Onder Koc; Safak Ozdemirci; Ata Topcuoglu; Ozturk Ozdemir

BACKGROUND Gonadotropins, as ovulation-inducing drugs, have been used widely to treat infertility. An epidemiologic correlation between infertility therapy and ovarian cancer development has been reported. However, the effect of gonadotropins in the formation of reproductive tract cancers is controversial. OBJECTIVE The aim of the study was to determine the in vivo genotoxic effects of gonadotropins on rat reticulocytes. METHODS In this prospective, randomized, controlled study, rats were randomly assigned to 1 of 5 groups. The calculated rat doses of 0.65 human menopausal gonadotropin (hMG), 0.95 hMG, 0.65 follitropin beta (FB), 0.95 FB, or normal saline (control group) were injected, respectively. These calculated rat doses (U/g) are based on average human gonadotropin doses of 150 and 225 IU/d for a 70-kg woman given in 2-mL saline (the control group received 2 mL of saline). Injections were administered once per day for 5 days, followed by 5 days of rest. Each treatment was repeated for 6 estrus cycles in the rats for a total of 12 estrus cycles. Six months after the last day of the 12(th) cycle, the rats were euthanized. Bone marrow tissues were removed, and pluripotent reticulocyte cells with micronuclei, nuclear buds, and binuclear abnormalities were analyzed using an in situ micronuclei assay under light microscopy. The proportion of micronucleated cells, cells with anaphase bridge, nuclear buds, and other nuclear abnormalities were measured. RESULTS The number of cells with nuclear buds and binuclear abnormalities in the hMG 225 and FB 225 groups was significantly higher (P < 0.05) than that from the hMG 150, FB 150, and control groups in the cytogenetic analysis of bone marrow stem cells. An increased rate of genotoxicity in all gonadotropin groups versus that of placebo was found. CONCLUSION In rats, the micronucleus genotoxicity assay suggests a dose-dependent gonadotropin effect on genomic instability in bone marrow stem cells in vivo.


Journal of Obstetrics and Gynaecology | 2013

Relationship of thyroid hormone levels and thyroid autoantibodies with early pregnancy loss and infertility

Bülent Duran; Tulay Ozlu; Onder Koc; C. Eşitken; Ata Topcuoglu

Prevalence of abnormalities in thyroid hormones and thyroid autoantibodies in patients with a history of early pregnancy loss (EPL) (n = 17) and unexplained infertility (UI) (n = 25), were compared with that of 45 control patients. TSH, antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG) antibody levels in UI and EPL groups were similar to that of the control group. TSH was normal in 39, 22 and 13 of control, UI and EPL patients, respectively. Among patients with a normal TSH, fT4 was higher (p < 0.001) and fT3 was lower (p < 0.001) in infertile patients when compared with the control group. Thyroid function tests seem to be associated with infertility but their association with EPL is weaker. Infertility seems to be associated with a high fT4 and low fT3 status. Thyroid autoantibodies do not seem to be associated with either infertility or EPL.


Clinical and Investigative Medicine | 2009

Effects of estrogens on oxidative protein damage in plasma and tissues in ovariectomised rats.

Ata Topcuoglu; Hafize Uzun; Huriye Balci; Mesut Karakus; I Çoban; Tuncay Altug; Seval Aydin; Deniz Topçuoglu; Ufuk Çakatay


Tohoku Journal of Experimental Medicine | 2005

The effect of hormone replacement therapy on oxidized low density lipoprotein levels and paraoxonase activity in postmenopausal women.

Ata Topcuoglu; Hafize Uzun; Seval Aydin; Nurhan Kahraman; Suphi Vehid; Gorkem Zeybek; Deniz Topçuoglu


Tohoku Journal of Experimental Medicine | 2005

Mood Scores in Relation to Hormone Replacement Therapies during Menopause: A Prospective Randomized Trial

Gogsen Onalan; Reside Onalan; Münire Akar; Ziya Gunenc; Ata Topcuoglu


Archives of Gynecology and Obstetrics | 2012

The effects of 17β-estradiol plus drospirenone on anthropometric and biochemical measures of adiposity in menopausal women.

Mesut Karakus; Remise Gelisgen; Ata Topcuoglu; Onur Guralp; Deniz Topçuoglu; Gonul Simsek; Seyfettin Uludag; Hafize Uzun


Clinical and Investigative Medicine | 2014

Effects of Hormone Replacement Therapy on Plasma and Tissue Fibrinolytic Activity in a Rat Model of Surgically Induced Menopause

Ata Topcuoglu; Mustafa Albayrak; Hayriye Erman; Huriye Balci; Mesut Karakus; Ilker Coban; Hafize Uzun


Journal of Medical Ultrasound | 2012

Detection and Localization of a Nonpalpable Subdermal Contraceptive Implant Using Ultrasonography: A Case Report

Kamil Gurel; Kaan Gideroglu; Ata Topcuoglu; Safiye Gurel; Ibrahim Saglam; Sukru Yazar

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Onder Koc

Abant Izzet Baysal University

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Bülent Duran

Abant Izzet Baysal University

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Melahat Emine Dönmez

Abant Izzet Baysal University

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Aysel Kükner

Abant Izzet Baysal University

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Fahri Yilmaz

Abant Izzet Baysal University

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Guler Bugdayci

Abant Izzet Baysal University

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