Atla Raju

Stereoselective total synthesis of (+)-hyptolide

Stereoselective synthesis of the naturally occurring 6-membered lactone hyptolide 1 is described. The main feature of the synthesis is the utility of the hitherto unexplored alkyne fragment derived from commercially available 3-butyn-1-ol (homopropargylic alcohol).

First total synthesis of cryptomoscatone F1

The total synthesis of cryptomoscatone F1 has been accomplished for the first time. The strategy involves chelation-controlled allylation, the addition of alkylzinc to an aldehyde and olefin cross-metathesis reactions as key steps. a new route to a vinyl lactone was explored.