Atsunori Sano

Additions of malononitrile radicals to alkenes under mild conditions using 2,2′-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (V-70) as an initiator

Abstract The attributes of 2,2′-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (V-70), which is an effective radical initiator at low temperature, in contrast to 2,2′-azobisisobutyronitrile (AIBN) are described.

A highly stereoselective synthesis of α-linked C-glycopyranosides using 2,2′-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (V-70)

Abstract α-Linked C-glycopyranosides were obtained effectively by the radical addition reaction using V-70, an effective radical initiator under mild conditions.

Efficient stereoselective synthesis of α-C-glycopyranosides using 2,2′-azobis(2,4-dimethyl-4-methoxyvaleronitrile) [V-70]

Abstract Efficient synthesis of α - C -glycopyranosides through a radical addition reaction using 2,2′-azobis(2,4-dimethyl-4-methoxyvaleronitrile) [V-70] as an initiator under mild condition was developed. This method made it possible to completely control the stereocenter at the anomeric position and obtain only the α-anomer in high yield compared with AIBN, Et 3 B, and photo irradiation methods.

An alternative synthesis of 2-benzyloxy-6-hydroxymethyl-3-isobutyl-5-methoxypyrazine 4-oxide, a key intermediate for synthesis of OPC-15161

2-Benzyloxy-6-hydroxymethyl-3-isobutyl-5-methoxypyrazine 4-oxide (5e), a key intermediate for synthesis of OPC-15161 (1a) having an inhibitory activity against superoxide anion generation, was prepared from 5-amino-2-benzyloxy-3-isobutyl-6-methoxycarbonylpyrazine 4-oxide (5b) by 3-step reaction