Atsushi Ikeyama

Studies on Changes in Tissue Water Constitution and Focal Brain Tissue Pressure in Experimental Cerebral Infarction

Knowledge of focal tissue pressure in infarcted brain areas is important with regard to the formation and spread of ischemic brain edema. Migration of edema fluid evolving from infarcted brain areas depends on the distribution of focal tissue pressure. To improve our understanding of pressure dynamics in ischemic cerebral edema, intracranial pressure (ICP) should be studied in focal cerebral ischemia within the closed skull. Although many experimental investigations have been conducted on the dynamics of ICP in cerebral ischemia, changes of local tissue pressure in ischemic brain with the skull remaining closed have not yet been subjected to an adequate analysis.

Mutual Relations Between Shifting of Focal Brain Structures and Intracranial Pressure

During expansion of an intracranial mass, variation in focal structural shiftings are possibly caused from tissue pressure gradients and local tissue plastic properties, convincingly playing an essential role in functional dynamics in the cranium and the formation of hernia. This study is designed to examine the mode of shifting in various Parts of the brain and its correlations to ICP change during the process of the gradual expansion of an intracerebral balloon.