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FEBS Letters | 1985

Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group

Yasuteru Iijima; Shuji Handa; Tomiichiro Oda; Atsushi Naito; Mitsuo Yamazaki

Griseolic acid inhibited cAMP phosphodiesterase (PDE) at low concentrations, the I 50 being of the order of 0.01–0.1 μM. Administration of griseolic acid to rats increased the cAMP level in liver and plasma several‐fold. It increased glycogen degradation in mouse liver and stimulated lipolysis in isolated rat fat cells. Griseolic acid did not block the adenosine‐elicited accumulation of cAMP in guinea pig brain slices. It had no effect on cAMP‐dependent protein kinase from rat liver nor on the adenyl cyclase from rat brain.


The Journal of Antibiotics | 1971

OXAZINOMYCIN, A NEW CARBON-LINKED NUGLEOSIDE ANTIBIOTIC

Tatsuo Haneishi; Takao Okazaki; Tadashi Hata; Chihiro Tamura; Masako Nomura; Atsushi Naito; Isao Seki; Mamoru Arai


The Journal of Antibiotics | 1985

Griseolic acid, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase I. Taxonomy, Isolation and characterization.

Takao Okazaki; Atsushi Naito; Yasuteru Iijima; Mitsuo Yamazaki


The Journal of Antibiotics | 1985

Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid.

Shuji Takahashi; Kayoko Kawazoe; Yoji Furukawa; Sadao Sato; Chihiro Tamura; Atsushi Naito


Archive | 1982

Enzyme inhibitor produced by cultivation of streptomyces microorganisms

Atsushi Naito; Takao Okazaki; Akira Terahara; Seigo Iwado; Mitsuo Yamazaki


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1991

Research and development of pravastatin

Yukichi Kishida; Atsushi Naito; Seigo Iwado; Akira Terahara; Yoshio Tsujita


The Journal of Antibiotics | 1984

Terferol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Isolation and characterization.

Ryuzou Enokita; Atsushi Naito; Yasuteru Iijima; Mitsuo Yamazaki


The Journal of Antibiotics | 1984

Terferol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. Structural elucidation.

Shuji Takahashi; Atsushi Naito; Sadao Sato; Sachiko Iwabuchi; Chihiro Tamura


The Journal of Antibiotics | 1980

ENZYMATIC CONVERSION OF CEPHAMYCIN C BY D-AMINO ACID OXIDASE FROM TRIGONOPSIS VARIABILIS

Nobufusa Serizawa; Keiko Nakagawa; Tatsuo Haneishi; Shoji Kamimura; Atsushi Naito


The Journal of Antibiotics | 1983

ISOLATION AND STRUCTURE OF OXIRAPENTYN

Shuji Takahashi; Yasuhiro Itoh; Michiko Takeuchi; Kouhei Furuya; Kentaro Kodama; Atsushi Naito; Tatsuo Haneishi; Sadao Sato; Chihiro Tamura

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