Aubin M. Heyndrickx

Toxicological analysis in a case of endosulfan suicide

Stomach, small intestine contents, “blood, liver, kidney and urine of a 28-years old man, were analyzed for residues of Endosulfan (6, 7, 8, 9, 10, 10-hexachloro-1, 5, 5a, 6, 9, 9a-hexahydro-6, 9-methano-2, 4, 3-benzo(e)dioxathiepin 3-oxide). The analysis results showed the presence of high concentrations of the two endosulfan isomers in all samples. Since also alcohol was present in all the tissues analyzed, it was concluded that the victim died of a combined endosulfan-alcohol poisoning. No other drugs were found.

A Case of Fatal Rotenone Poisoning in a Child

A case of a fatal rotenone poisoning in a three-and-a-half-year-old girl is described. The case report and autopsy findings are mentioned. For the extraction of rotenone out of biological samples, a solvent partitioning and silica gel open column chromatographic cleanup procedure has been used. The determination of rotenone was performed by high pressure liquid chromatography.

Comparativ study of the gas—liquid chromatographic behavior of the pentalfuorobenzyl esters and the methyl esters of ten chlorophenoxyalkyl acids

Abstract The gas—liquid chromatographic (GLC) behaviour of the pentafluorobenzyl and methyl esters of ten structurally related chlorophenoxyalkyl acids was studied by comparing their retention indices on nine frequently used liquid phases with increasing McReynolds constants. The resolution of each liquid phase is different for the pentafluorobenzyl and the methyl ester derivatives. However, using an apolar and a polar phase, a graph of the retention index ( I ) on the polar phase against the difference in retention indices (Δ I ) between the polar and the non-polar phase shows a good correlation between structure and retention in gas—liquid chromatography. The graphs constructed for the pentafluorobenzyl and for the methyl esters have the same structure—retention correlations.

In vitro adsorption of tilidine HCL by activated charcoal

In vitro studies were carried out in order to determine the adsorption of tilidine HCl, a narcotic analgesic, by activated charcoal (max. adsorption capacity 185.5 mg/g of charcoal). The path of the adsorption isotherms at pH 1.2 and 7.5 suggests that the in vivo adsorption of tilidine HCl may be increased when the drug passes from the stomach to the intestine, unless the intestinal content exerts a displacing effect. Nevertheless, the adsorption was dependent on the quantity of activated charcoal used, becoming more complete when the quantity of activated charcoal was increased. The effects of additives on the adsorption capacity of activated charcoal were also investigated in vitro. Ethanol, sorbitol and sucrose significantly reduced drug adsorption, while cacao powder, milk and starch had no effect on tilidine adsorption. At an acid pH, Federa Activated Charcoal significantly adsorbed more drug than either Norit A or Activated Charcoal Merck.

Numerical taxonomy of common phases for gas—liquid chromatography, using chlorophenoxy alkyl esters as test substances

Abstract Numerical taxonomy of the retention indices of the methyl and pentafluorobenzyl esters of ten chlorophenoxy alkyl acids has been employed to determine the relationships between phases used for gas—liquid chromatography.

Distribution of Fluoride in Human Bones Collected for the Evaluation of Industrial Air Pollution

Abstract Fluoride concentrations were determined in human bones in order to establish whether bone fluoride levels could be indicative of a chronic exposure to a fluoride contaminated environment. The bone samples studied were mainly obtained from thirteen post mortem examinations. In ten of these cases, the persons involved had lived in rural areas, free of any fluoride pollution (reference cases). In the other three cases, the individuals involved had lived for many years in the neighborhood of a fluoride emitting plant. In addition, an analysis was also performed on a bone fragment procured by a 71-year-old woman who underwent an arthroplastic reconstruction of the hip. This patient also had a previous history of chronic fluoride intoxication. The fluoride concentrations measured in the four suspected cases were within the limits indicated by the reference cases. As such they were not directly indicative of a chronic exposure to industrial fluoride pollution.