Augusto Maggioni

Primary large cell neuroendocrine carcinoma of the renal pelvis: a case report.

We report a case of primary large cell neuroendocrine carcinoma of the renal pelvis, diagnosed in a 79-year-old man. The abdominal computed tomography showed a solid, vegetant lesion in the left renal pelvis, conditioning marked hydronephrosis. The patient underwent radical nephroureterectomy. The histological examination showed a large cell neuroendocrine carcinoma associated with a high-grade urothelial carcinoma, with local invasion (pT3). Large cell renal neuroendocrine carcinomas are rare tumors with an aggressive course and a bad prognosis. At present, only five cases were reported in literature.

Single session cystolitholapaxy and PCNL for encrusted DJ stent with large associated stone burden

INTRODUCTION Ureteral stent use is commonplace in urology to prevent or relieve ureteral obstruction. If ureteral stents are neglected, they can cause severe morbidity due to migration, occlusion, encrustation, breakage, stone formation, and even death, due to life-threatening urosepsis or complications related to operative intervention. Extracorporeal shockwave lithotripsy, ureterorenoscopy, electrohydraulic lithotripsy, laser lithotripsy, and percutaneous nephrolitholapaxy (PCNL) have been reported for forgotten ureteral stent management, but currently there are no guidelines for this challenging situation and only few algorithms have been introduced by some studies. METHODS We present a case of a man presenting with an encrusted left double J (DJ) stent, inserted two years before, and bulky radiolucent lithiasis at both ends of the stent. The patient was studied with intravenous pyelogram and non contrast-enhanced computed tomography, and then treated with cystolithotripsy and PCNL in a single session. RESULTS Complete clearance of the stones was obtained and the DJ stent was removed without breaking from the percutaneous access. CONCLUSIONS Neglected stents still represent a challenge in urology: while endourology remains the best option for treatment, the management of ureteral stents should be based on follow-up and prevention, using for example a computerized warning and stent retrieval software system.

Shock wave lithotripsy in the elderly: our experience related to literature review

Background The more and more common use of abdominal ultrasonography and of other imaging techniques, the increase of the life expectancy and therapies for calcium metabolism, has led to a higher diagnosis rate of renal stones in the elderly. At the moment, extracorporeal shock wave lithotripsy is considered the first-line therapy in the majority of reno-ureteral stones. Objectives To prove the efficacy and safety of extracorporeal shock wave lithotripsy also in the elderly population. Materials and Methods We proceeded to a retrospective study on patients aged over 70 years, who underwent SWL at our division from January 1996 to April 2005, with Storz Modulith SLX electromagnetic lithotripter. We defined as stone-free those patients who did not show any stone fragment in the following ultrasonography and abdomen X-ray control. In addition, we performed a medium/long-term follow-up. We adopted as “control group” 115 patients aged less than 60 years, who underwent lithotripsy with the same lithotripter from June 2007 to January 2008. Results In the short-term follow-up, at the end of the single treatment or of the course of treatments (1-3 months after treatment), we observed: 72.1% (83/115) stone-free subjects, 20% (23/115) of cases with stone fragments that could be eliminated (<4 mm), 3.5% (4/115) with stone fragments >4 mm, 4.3% (5/115) unchanged cases; 2 of these (1.7%) underwent endoscopic lithotripsy and one percutaneous lithotripsy (0.9%). Concerning the medium/long-term follow-up (mean 59.2 months, range 7 mo-108 mo), we observed: 59.8% (67/112) stone-free cases, 25.9% (29/112) recurring stones, 11.6% (13/112) re-growth, 2,7% (3/112) unchanged cases. In the short-term follow-up, comparing the study group with the control one we observed: – No statistically significant difference regarding the treatment side effects in the two groups; – A lower stone-free percentage in caliceal stones in the elderly than in the younger patients (SFR = 62.5% vs 70.3%) – A stone-free percentage for non-caliceal stones similar in the older and the young patients (SFR = 79.1% vs 80.4%). Conclusions Shock wave lithotripsy proves to be effective in the first-line treatment of renal stones in the elderly, yielding good results with no increase of side effects.

[Multiple non-responding ESWL lithiasis in ectopic pelvic kidney: laparotomic surgical management].

A 34 year-old male with multiple lithiasis of ectopic pelvic left kidney, which for 5 years had been causing pain in the left iliac region irradiating to ipsilateral inguinal region and testis. 4 ESWL treatments were unsuccessful. The diagnostic imaging (Angio-CT + Uro-CT) showed ectopic pelvic left kidney with abnormal vascularisation, characterised by multiple lithiasis extending in total area of 4×2 cm with shorter ureter. Right kidney was in normal position. A left pyelocalicolithotomy after DJ stent positioning was performed.