Aung Myint

Strongyloides hyperinfection syndrome in an immunocompetent host resulting in bandemia and death

Strongyloides stercoralis infection is usually asymptomatic but can result in a hyperinfection syndrome, most commonly triggered by acquired or iatrogenic immunosuppression. Here, we present a case of a man aged 60 years originally from a strongyloides endemic area with a medical history of alcohol abuse who presents with strongyloides hyperinfection syndrome (SHS) complicated by partial small bowel obstruction, pulmonary haemorrhage, large bandemia without eosinophilia and cardiac arrest resulting in death. This case is notable for the presence of bandemia and absence of eosinophilia, lack of historical risk factors for hyperinfection, specifically corticosteroid immunosuppressants, and dramatic decline in clinical status which ultimately resulted in the patients death. Clinicians should suspect SHS in immunocompetent patients who are from an endemic area and who have persistent gastrointestinal and/or pulmonary manifestations in the absence of a clear cause.

Sa1035 A High Stakes Learning Environment: Fellow-Performed Colonoscopies Are Associated With Lower ADRs

and presentation skills. Seventy-five percent of these fellows subsequently taught gastrointestinal pathophysiology. The majority of fellows organized teaching sessions locally, regionally and nationally in their current positions. One third perceived that the fellowship helped their academic promotions. On the basis of these data, we recommend that an optional, unfunded Gastrointestinal Pathophysiology Teaching Fellowship be incorporated into GI Fellowship Programs as a means of increasing academic teaching and leadership skill sets in interested fellows.

Su1101 Investigating the Smoking Gun: Should Tobacco Use Be Incorporated Into Colorectal Screening Guidelines?

Background: Inadequate bowel preparation before colonoscopy is common, resulting in clinical and economic harms. The US Multi-Society Taskforce advocates use of both written and oral instructions for patients before colonoscopy. However, little is known about the most effective method of patient education. This systematic review aims to assess the effectiveness of patient-oriented educational interventions in improving the quality of bowel preparation. Methods: Studies were identified from MEDLINE, EMBASE, Cochrane, CINAHL, and Web of Science. Two investigators evaluated each abstract for the following inclusion criteria: evaluation of a patient-oriented educational intervention, prospective design, and measurement of bowel preparation quality with a validated scale. Included studies underwent duplicate data extraction by 2 investigators using a standardized approach. Extracted data included the method of intervention, timing of intervention, staffing of intervention, purgative used, bowel preparation scale used, and bowel preparation quality. Methodological quality of studies was assessed using amodified Downs and Black instrument. Due to significant heterogeneity in assessment of outcomes, meta-analysis was not performed. Results: 1080 unique published studies were identified, and 7 of these studies met inclusion criteria. Five studies were randomized controlled trials, and 2 were quasi-experimental. The number of patients analyzed ranged from 99 to 969. 3 studies were performed in the US, 2 in Taiwan, 1 in China, and 1 in Korea. 3 interventions used paper-based tools (1 cartoon, 2 illustrated brochures), 2 interventions used videos, 1 intervention used face-to-face education, and 1 used telephone calls. In 6 of the 7 studies, the educational intervention was effective in improving bowel preparation quality, with an absolute increase in bowel preparation adequacy ranging from 2% to 32%. No study accounted for all significant confounders of bowel preparation quality (i.e. constipation, diabetes, opiates, socioeconomic status, literacy rate, age, gender, BMI). Validity scores ranged from 12-23, with a median value of 18, indicating fair methodological quality. Conclusions: Patient-oriented educational interventions significantly improve bowel preparation quality, but existing studies are of variable quality and may have limited generalizability. Gastroenterologists should work internally and with referring practices to ensure that patients receive evidence-based preparation education. Future studies should focus on comparative effectiveness and cost-effectiveness of educational interventions