Aurélie Bocquier

Small-area analysis of social inequalities in residential exposure to road traffic noise in Marseilles, France

BACKGROUND Few studies have focused on the social inequalities associated with environmental noise despite its significant potential health effects. This study analysed the associations between area socio-economic status (SES) and potential residential exposure to road traffic noise at a small-area level in Marseilles, second largest city in France. METHODS We calculated two potential road noise exposure indicators (PNEI) at the census block level (for 24-h and night periods), with the noise propagation prediction model CadnaA. We built a deprivation index from census data to estimate SES at the census block level. Locally estimated scatterplot smoothing diagrams described the associations between this index and PNEIs. Since the extent to which coefficient values vary between standard regression models and spatial methods are sensitive to the specific spatial model, we analysed these associations further with various regression models controlling for spatial autocorrelation and conducted sensitivity analyses with different spatial weight matrices. RESULTS We observed a non-linear relation between the PNEIs and the deprivation index: exposure levels were highest in the intermediate categories. All the spatial models led to a better fit and more or less pronounced reductions of the regression coefficients; the shape of the relations nonetheless remained the same. CONCLUSION Finding the highest noise exposure in midlevel deprivation areas was unexpected, given the general literature on environmental inequalities. It highlights the need to study the diversity of the patterns of environmental inequalities across various economic, social and cultural contexts. Comparative studies of environmental inequalities are needed, between regions and countries, for noise and other pollutants.

Obésité: où en sommes-nous ?

Points essentiels Le surpoids et l’obesite correspondent a un exces de masse grasse, defini et evalue, en pratique clinique, par l’indice de masse corporelle (IMC – rapport du poids, en kilogrammes, sur le carre de la taille, en metre). Les consequences de l’obesite sur la sante sont nombreuses: complications metaboliques, cardiovasculaires et mecaniques, predisposition a certains cancers mais egalement repercussions psychosociales. En France, en 2003, 30% des adultes etaient en surpoids et 11% etaient obeses. L’augmentation des reserves adipeuses caracterisant l’obesite resulte d’un desequilibre de la balance energetique. Ce desequilibre releve d’interactions complexes, expliquant l’heterogeneite clinique et biologique de l’obesite humaine. L’espoir de voir l’epidemie maitrisee dans les annees a venir repose sans doute plus sur la mise en place d’actions coordonnees entre divers acteurs de la societe que sur l’attente d’un medicament specifique.

Is exposure to night-time traffic noise a risk factor for purchase of anxiolytic–hypnotic medication? A cohort study

BACKGROUND Studies suggest that road traffic noise increases risks of sleep disturbances, anxiety and depressive symptoms, but few have focused on psychotropic drug use. We examined whether exposure to night-time road traffic noise in Marseilles (France) is associated with an increased risk of purchasing anxiolytic or hypnotic medications. METHODS Cohort of 190,617 inhabitants of Marseilles (aged 18-64 years) covered by the National Health Insurance Fund. We used the CadnaA noise propagation prediction model to calculate a potential road noise exposure indicator at dwellings for the night-period: Ln. Association between the number of purchases of anxiolytics-hypnotics in 2008-9 and the Ln was analysed with a zero-inflated negative binomial (ZINB) model adjusted for characteristics of individuals (sociodemographic, consultations with general practitioners, presence of chronic psychiatric disorder), prescribers (demographic, specialty, workload) and neighbourhoods (medical density, complaints filed for environmental noise). Analyses were stratified by the deprivation level of the census block of residence to control for the confounding effects of neighbourhood socio-economic status. RESULTS The ZINB model showed a small but significant increase in the risk of purchasing higher numbers of anxiolytics-hypnotics for Ln greater than 55 dB(A) only in the low deprivation stratum. CONCLUSION We found some evidence that potential exposure to night-time road traffic noise might affect individual use of anxiolytics-hypnotics. Further research based on strictly individual approaches is warranted to assess exposure to road traffic noise more precisely and reliably than allowed by noise propagation prediction models.

Social inequalities in new antidepressant treatment: a study at the individual and neighborhood levels.

PURPOSE To determine whether social inequalities in new antidepressant treatment exist at the individual and/or neighborhood level; and their relation to access to prescribers and/or processes of care (treatment initiation and duration). METHODS We followed 316,412 inhabitants of Marseilles (aged 18-64 years) covered by the National Health Insurance Fund for 2.5 years. We analyzed new treatments (≥1 purchase of antidepressants and none in the 6 months before the first one), and new long treatments (≥4 within 6 months after the first purchase). We tested their associations with high individual disadvantage and census block deprivation in a multivariate, multilevel logistic model adjusted for consultations with general practitioners and psychiatrists to control for access to care. RESULTS High individual disadvantage was not associated with the probability of new treatments, but it was with lower odds of receiving new long treatments. Residing in deprived census blocks was associated with lower odds of receiving treatment for both dependent variables. CONCLUSIONS Our results suggest that social inequalities at the individual and neighborhood levels in new antidepressant treatment occur in access to specialty care and in treatment initiation and affect its duration. Further research is warranted to improve our understanding of their mechanisms.

Prevalence and correlates of vaccine hesitancy among general practitioners: a cross-sectional telephone survey in France, April to July 2014

This article sought to estimate the prevalence of vaccine hesitancy (VH) among French general practitioners (GPs) and to study its demographic, professional and personal correlates. We conducted a cross-sectional telephone survey about GPs’ vaccination-related attitudes and practices in 2014 in a national panel of 1,712 GPs in private practice, randomly selected from an exhaustive database of health professionals in France. A cluster analysis of various dimensions of VH (self-reported vaccine recommendations, perceptions of vaccine risks and usefulness) identified three clusters: 86% of GPs (95% confidence interval (CI): 84–88) were not or only slightly vaccine-hesitant, 11% (95% CI: 9–12) moderately hesitant and 3% (95% CI: 3–4) highly hesitant or opposed to vaccination. GPs in the latter two clusters were less frequently vaccinated and reported occasional practice of alternative medicine more often than those in the first cluster; they also described less experience with vaccine-preventable diseases and more experience with patients who they considered had serious adverse effects from vaccination. This study confirms the presence of VH among French GPs but also suggests that its prevalence is moderate. Given GPs’ central role in vaccination, these results nevertheless call for a mobilisation of stakeholders to address VH among GPs.

Axe corticotrope et stress chronique dans l'obésité abdominale et le syndrome métabolique

Points essentiels • Des indices biologiques d’une hyperactivite de l’axe corticotrope ont ete observes dans l’obesite abdominale commune, qui est cliniquement proche de celle de l’hypercorticisme. • Cette hyperactivite peut contribuer au developpement de l’obesite abdominale et de ses complications metaboliques et cardiovasculaires. • Plusieurs mecanismes peuvent en etre a l’origine: des facteurs genetiques, l’hygiene de vie (facteurs nutritionnels, sedentarite), mais egalement le stress chronique. • Des etudes cliniques methodologiquement indiscutables sont necessaires pour une evaluation objective du role du stress chronique dans cette pathologie.

Social Differentiation of Sun-Protection Behaviors: The Mediating Role of Cognitive Factors

INTRODUCTION Adherence to sun-protection guidelines in developed countries is low, especially among people of low SES. Mechanisms underlying this social differentiation are poorly understood. This study aimed to examine the social differentiation of sun-protection behaviors and of two cognitive factors (knowledge about both sun health and behavioral risk factors for cancer) and to determine if these cognitive factors mediate the association between SES and sun-protection behaviors. METHODS Data came from the 2010 Baromètre Cancer survey (analyzed in 2014), a random cross-sectional telephone survey conducted among the French general population (n=3,359 individuals aged 15-75 years). First, bivariate associations between a composite individual SES indicator (based on education level, occupation, and income) and both sun-protection behaviors and cognitive factors were tested with chi-square tests and ANOVA. Then, confirmatory factor analysis and structural equation modeling were used to test the mediating role of cognitive factors with a multiple mediation model including four latent variables. RESULTS In bivariate analyses, the individual SES indicator was positively associated with sun-protection behaviors and both cognitive factors. Multiple mediation analyses showed that both cognitive factors partially mediated the effect of individual SES on sun-protection behaviors. The overall proportion of mediated effects was 48%. The direct effect of SES remained significant. CONCLUSIONS These results suggest that interventions aimed at modifying the knowledge and perceptions of people of low SES might help to reduce social differentiation of sun-protection behaviors. Further qualitative research is needed to better understand these cognitive factors and develop suitable prevention messages.

‘I don’t know if I’m making the right decision’: French mothers and HPV vaccination in a context of controversy

Human papillomavirus (HPV) vaccination coverage in France has fallen substantially since 2010 and the onset of a media controversy on the subject of its safety and efficacy. In this article we examine how and why mothers agree or do not agree to HPV vaccination for their daughters. We draw on data from a survey of French mothers of girls within the HPV vaccination target population (11–14 years old). We used semi-structured interviews to examine their perceptions of this relatively new vaccine and how such perceptions were shaped by their past experiences of vaccines and health in general. We also talked to them about their sources of information, their level of trust in these sources, and how their perception of risk changed as they accessed different and often contradictory information. We found that mothers’ fears of side effects and of ‘new’ vaccines was one of the main reason why they either refused to get their daughters vaccinated or hesitated. Mothers told us that they consulted several different sources, tended to trust their doctors most, but still questioned their recommendations. Although they presented the media and the Internet as untrustworthy, the information from those sources, whether gathered proactively or in passing, significantly influenced their decisions by introducing doubt or by prompting more information-seeking. In this article we show the dynamic nature of this decision-making process and we found that a substantial number of the mothers in our study said that they had been advised by at least one of their doctors not to have their daughter vaccinated.

Socioeconomic differences in childhood vaccination in developed countries: a systematic review of quantitative studies

ABSTRACT Introduction: The reasons for vaccine hesitancy and its relation to individual socioeconomic status (SES) must be better understood. Areas covered: This review focused on developed countries with programs addressing major financial barriers to vaccination access. We systematically reviewed differences by SES in uptake of publicly funded childhood vaccines and in cognitive determinants (beliefs, attitudes) of parental decisions about vaccinating their children. Using the PRISMA statement to guide this review, we searched three electronic databases from January 2000 through April 2016. We retained 43 articles; 34 analyzed SES differences in childhood vaccine uptake, 7 examined differences in its cognitive determinants, and 2 both outcomes. Expert commentary: Results suggest that barriers to vaccination access persist among low-SES children in several settings. Vaccination programs could be improved to provide all mandatory and recommended vaccines 100% free of charge, in both public organizations and private practices, and to reimburse vaccine administration. Multicomponent interventions adapted to the context could also be effective in reducing these inequalities. For specific vaccines (notably for measles, mumps, and rubella), in UK and Germany, uptake was lowest among the most affluent. Interventions carefully tailored to respond to specific concerns of vaccine-hesitant parents, without reinforcing hesitancy, are needed.

Underlying factors impacting vaccine hesitancy in high income countries: A review of qualitative studies

ABSTRACT Introduction. While the scientific consensus on the benefits of vaccination is unambiguous, there is a growing proportion of the population that is skeptical about vaccination. The idea that vaccination programs are losing their momentum concerns public health agencies throughout the world. Many studies assessing determinants of vaccine acceptance have been published in the last decade. Areas covered. In this article, we review the existing qualitative literature on parents’ attitudes toward childhood vaccination. Studies were included if they: (1) focused on the views, decision-making, or experiences of caregivers (hereafter, referred to as ‘parents’) regarding vaccinations for young children; (2) used qualitative methods for both data and data analysis; (3) were conducted in countries that ranked ‘very high’ on the 2016 United Nations Human Development Index; and (4) had been peer-reviewed. Twenty-two (22) studies met our inclusion criteria and were reviewed, using the socio-ecological model as a conceptual framework. Expert commentary. Parental vaccination decisions are complex and multi-dimensional. Experiences, emotions, routine ways of thinking, information sources, peers/family, risk perceptions, and trust, among other factors, inform parents’ attitudes and decision-making processes. Further research is needed in order to design evidence-informed responses to vaccine hesitancy appropriate to the setting, context, and hesitant subgroups.