Axel Nordberg

Bifunctional Dendrimers: From Robust Synthesis and Accelerated One‐Pot Postfunctionalization Strategy to Potential Applications

A fourth wheel: Two sets of bifunctional AB(2)C dendrimers having internal acetylene/azides and external hydroxy groups were constructed utilizing benign synthetic protocols. An in situ postfunctionalization strategy was successfully carried out to illustrate the chemoselective nature of these dendrimers. The dendrimers were also transformed into dendritic nanoparticles or utilized as dendritic crosslinkers for the fabrication hydrogels.

Highly Adhesive Phenolic Compounds as Interfacial Primers for Bone Fracture Fixations

Bone fractures are today stabilized with screws and metal plates. More complicated fractures require alternative treatments that exclude harsh surgical conditions. By adapting the benign and UV initiated thiol-ene reaction, we efficiently fabricated triazine-based, fiber-reinforced adhesive patches within 2 s. To enhance their bone adhesion properties, we found that a pre-treatment step of bone surfaces with phenolic dopamine and poly(parahydroxystyrene) compounds was successful. The latter display the greatest E-module of 3.4 MPa in shear strength. All patches exhibited low cytotoxicity and can therefore find potential use in future treatments of bone fractures.

Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications

Two sets of heterofunctional dendritic frameworks displaying an inversed and exact number of ene and azide groups have successfully been synthesized and post-functionalized with biorelevant molecules. Their facile scaffolding ability enabled the fabrication of soft and azide functional dendritic hydrogels with modulus close to muscle tissue. The dendritic scaffolds are furthermore shown to be promising primers for the development of novel bone fracture stabilization adhesives with shear strengths succeeding commercial Histroacryl®.

Fiber Reinforced Adhesive Patch (FRAP): A New Technology for Minimal Invasive Treatments of Bone Fractures

Instead of screws and metal plates we have developed a unique adhesive implant to stabilize the various types of bone fractures defined as the Fiber Reinforced Adhesive Patch (FRAP) technology. The new implant consists of an adhesive strengthened with fibers to form a composite patch. The FRAP technology is developed as a degradable adhesive facilitating a mechanically strong triazine system based on non-toxic allylic and thiol compounds. The thiolene cross linking strategy is highly desirable in a surgical environment as it can be performed via minimally invasive optical fibers and with excellent tolerance to oxygen. The number of layers and the size of the FRAP technology is chosen by the surgeon depending on the fracture characteristics and the anticipated load on the fracture. When at place, the tailor-made FRAP technology is photo-cured by UV light to a hard composite thereby bridging and stabilizing the fracture or the skull bone after neurosurgical operations. The experimental and numerical analysis on bovine bone fractures shows that the new FRAP technology should become an excellent alternative or complement to existing metal implants.

Stability and fibre reinforced adhesive fixation of vertebral fracture in the upper cervical spine

Stability and fibre reinforced adhesive fixation of vertebral fractures in the upper cervical spine