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Ayako Nakamura

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Publication

Featured researches published by Ayako Nakamura.

Bioorganic & Medicinal Chemistry Letters | 2011

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.

Oana Cociorva; Bei Li; Tyzoon K. Nomanbhoy; Qiang Li; Ayako Nakamura; Kai Nakamura; Masahiro Nomura; Kyoko Okada; Shigeki Seto; Kazuhiro Yumoto; Marek Liyanage; Melissa C. Zhang; Arwin Aban; Brandon Leen; Anna Katrin Szardenings; Jonathan S. Rosenblum; John W. Kozarich; Yasushi Kohno; Kevin Shreder

The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this class were potent and highly selective GSK-3 inhibitors.

Archive | 2008

Spirocyclic aminoquinolones as gsk-3 inhibitors

Oana Cociorva; Yasumichi Fukuda; Yasushi Kohno; Bei Li; Kyoko Okada; Ayako Nakamura; Masahiro Nomura; Shigeki Seto; Anna Katrin Szardenings; Kazuhiro Yumoto

Archive | 2007

Aminoquinolones as GSK-3 Inhibitors

Oana Cociorva; Bei Li; Anna Katrin Szardenings; Yasumichi Fukuda; Masahiro Nomura; Shigeki Seto; Kazuhiro Yumoto; Kyoko Okada; Ayako Nakamura

Archive | 2008

SPIROCYCLIC AMINOQUINOLNES AS GSK-3 INHIBITORS

Oana Cociorva; Yasumichi Fukuda; Yasushi Kohno; Bei Li; Kyoko Okada; Ayako Nakamura; Masahiro Nomura; Shigeki Seto; Anna Katrin Szardenings; Yumoto Kazuhiro

Archive | 2017

composto, composição farmacêutica, método para tratar, prevenir ou melhorar uma doença mediada por gsk-3, uso de um composto, e, artigo de fabricação.

Ayako Nakamura; Bei Li; Katrin Szardenings; Kazuhiro Yumoto; Kyoko Okada; Masahiro Nomura; Oana Cociorva; Shigeki Seto; Yasumichi Fukuda; Yasushi Kohno

Archive | 2008

Aminoquinolones spirocycliques utilisées en tant qu'inhibiteurs de gsk-3

Oana Cociorva; Yasumichi Fukuda; Yasushi Kohno; Bei Li; Kyoko Okada; Ayako Nakamura; Masahiro Nomura; Shigeki Seto; Katrin Szardenings; Kazuhiro Yumoto

Archive | 2008

Spirocyclische aminochinolone als gsk-3-inhibitoren

Oana Cociorva; Yasumichi Fukuda; Yasushi Kohno; Bei Li; Ayako Nakamura; Masahiro Nomura; Kyoko Okada; Shigeki Seto; Katrin Szardenings; Kazuhiro Yumoto

Archive | 2007

Aminoquinolones en tant qu'inhibiteurs du GSK-3

Oana Cociorva; Bei Li; Anna Katrin Szardenings; Yasumichi Fukuda; Masahiro Nomura; Shigeki Seto; Kazuhiro Yumoto; Kyoko Okada; Ayako Nakamura

Archive | 2007

Aminoquinolones utilisées comme inhibiteurs de la gsk-3

Oana Cociorva; Bei Li; Katrin Szardenings; Yasumichi Fukuda; Masahiro Nomura; Shigeki Seto; Kazuhiro Yumoto; Kyoko Okada; Ayako Nakamura

Archive | 2007

Aminochinolone als GSK-3-Hemmer

Oana Cociorva; Bei Li; Anna Katrin Szardenings; Yasumichi Fukuda; Masahiro Nomura; Shigeki Seto; Kazuhiro Yumoto; Kyoko Okada; Ayako Nakamura

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Collaboration

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Masahiro Nomura

Tohoku University

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John W. Kozarich

Merck

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Tyzoon K. Nomanbhoy

Scripps Research Institute

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Tomohiro Ide

University of Tsukuba

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