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Ayako Nasu

Kikkoman

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Featured researches published by Ayako Nasu.

Carbohydrate Research | 1998

New enzymatic synthesis of 63-modified maltooligosaccharides and their inhibitory activities for human α-amylases

Riichiro Uchida; Ayako Nasu; Shoichi Tokutake; Kouichi Kasai; Koichiro Tobe; Nobuyuki Yamaji

Ten new 6(3)-modified maltopentaoses and tetraoses were synthesized by enzymatic reactions utilizing cyclodextrin glycosyltransferase (EC 2.4.1.19) and subsequent human salivary alpha-amylase (HSA) (EC 3.2.1.1). Among these compounds, alpha-D-glucopyranosyl-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose (11) and alpha-D-glucopyranosyl-(1-->4)-(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose (12) showed strong inhibitory activities for human pancreatic alpha-amylase (HPA) and HSA. The IC50 of 6(3)-deoxymaltopentaose 11 (8.0 x 10(-5) M for HPA, 1.0 x 10(-4) M for HSA) and 6(3)-deoxymaltotetraose 12 (2.0 x 10(-3) M for HPA, 2.0 x 10(-3) M for HSA) were lower than that of 6(3)-deoxymaltotriose [(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)-alpha-D- glucopyranosyl-(1-->4)-D-glucopyranose 13; 2.0 x 10(-3) M for HPA, 4.2 x 10(-2) M for HSA].

Chemical & Pharmaceutical Bulletin | 1999

Synthesis of new N-containing maltooligosaccharides, α-amylase inhibitors, and their biological activities

Riichiro Uchida; Ayako Nasu; Shoichi Tokutake; Kouichi Kasai; Koichiro Tobe; Nobuyuki Yamaji

Archive | 2000

Malto-oligosaccharide derivatives and uses thereof

Riichiro Uchida; Ayako Nasu; Yukihiko Iwai; Takao Someya; Koichiro Tobe

Carbohydrate Research | 1996

A convenient preparation of maltooctaose and maltononaose by the coupling reaction of cyclomaltodextrinase

Riichiro Uchida; Ayako Nasu; Kouichiro Tobe; Tetsuya Oguma; Nobuyuki Yamaji

Chemical & Pharmaceutical Bulletin | 1997

An Efficient Preparation of Acetyl Isoflavone Glucoside

Toru Izumi; Ayako Nasu; Shigehiro Kataoka; Shoichi Tokutake; Akio Obata; Koichiro Tobe

Archive | 1985

Process for preparation of N6-substituted 3',5'-cyclic adenosine monophosphate and salt thereof

Shigehiro Kataoka; Ayako Nasu; Nobuyuki Yamaji; Motohiko Kato

Journal of pharmacobio-dynamics | 1992

Effect of adenosine 3',5'-cyclic monophosphate derivatives on acute liver injury induced by carbon tetrachloride

Makoto Saito; Ayako Nasu; Shigehiro Kataoka; Nobuyuki Yamaji; Atsushi Ichikawa

Journal of pharmacobio-dynamics | 1989

Cytotoxic Effect of 8-Amino Adenosine 3', 5'-Cyclic Monophosphate on FM3A Mouse Mammary Tumor Cells

Makoto Saito; Ayako Nasu; Shigehiro Kataoka; Katsunori Ohshita; Nobuyuki Yamaji

Archive | 1996

Malto-oligosaccharide derivative, and production and use of the same

Mamoru Kikuchi; Katsuko Matsuura; Ayako Nasu; Riichiro Uchida; Jun Yamakoshi; Nobuyuki Yamatsugu; 理一郎 内田; 信幸 山次; 純 山越; 克子 松浦; 護 菊地; 綾子 那須

Chemical & Pharmaceutical Bulletin | 1991

Studies on the Synthesis of COmpounds Related to Adenosine 3', 5'-Cyclic Phosphate. IX. Synthesis and Cytotoxic Effect of Adenosine 3', 5'-Cyclic Alkylphosphoramidates

Makoto Saito; Shigehiro Kataoka; Ayako Nasu; Nobuyuki Yamaji; Atsushi Ichikawa

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Nobuyuki Yamaji

Niigata University

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Shigehiro Kataoka

Kikkoman

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Riichiro Uchida

Kikkoman

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Koichiro Tobe

Kikkoman

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Makoto Saito

Kikkoman

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Motohiko Kato

University of Tokyo

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Takao Someya

Kikkoman

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Yukihiko Iwai

Kikkoman

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Atsushi Ichikawa

Kyoto University

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Shoichi Tokutake

Kikkoman

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