Ayako Nasu
Kikkoman
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Publication
Featured researches published by Ayako Nasu.
Carbohydrate Research | 1998
Riichiro Uchida; Ayako Nasu; Shoichi Tokutake; Kouichi Kasai; Koichiro Tobe; Nobuyuki Yamaji
Ten new 6(3)-modified maltopentaoses and tetraoses were synthesized by enzymatic reactions utilizing cyclodextrin glycosyltransferase (EC 2.4.1.19) and subsequent human salivary alpha-amylase (HSA) (EC 3.2.1.1). Among these compounds, alpha-D-glucopyranosyl-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose (11) and alpha-D-glucopyranosyl-(1-->4)-(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)- alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose (12) showed strong inhibitory activities for human pancreatic alpha-amylase (HPA) and HSA. The IC50 of 6(3)-deoxymaltopentaose 11 (8.0 x 10(-5) M for HPA, 1.0 x 10(-4) M for HSA) and 6(3)-deoxymaltotetraose 12 (2.0 x 10(-3) M for HPA, 2.0 x 10(-3) M for HSA) were lower than that of 6(3)-deoxymaltotriose [(6-deoxy-alpha-D-glucopyranosyl)-(1-->4)-alpha-D- glucopyranosyl-(1-->4)-D-glucopyranose 13; 2.0 x 10(-3) M for HPA, 4.2 x 10(-2) M for HSA].
Chemical & Pharmaceutical Bulletin | 1999
Riichiro Uchida; Ayako Nasu; Shoichi Tokutake; Kouichi Kasai; Koichiro Tobe; Nobuyuki Yamaji
Archive | 2000
Riichiro Uchida; Ayako Nasu; Yukihiko Iwai; Takao Someya; Koichiro Tobe
Carbohydrate Research | 1996
Riichiro Uchida; Ayako Nasu; Kouichiro Tobe; Tetsuya Oguma; Nobuyuki Yamaji
Chemical & Pharmaceutical Bulletin | 1997
Toru Izumi; Ayako Nasu; Shigehiro Kataoka; Shoichi Tokutake; Akio Obata; Koichiro Tobe
Archive | 1985
Shigehiro Kataoka; Ayako Nasu; Nobuyuki Yamaji; Motohiko Kato
Journal of pharmacobio-dynamics | 1992
Makoto Saito; Ayako Nasu; Shigehiro Kataoka; Nobuyuki Yamaji; Atsushi Ichikawa
Journal of pharmacobio-dynamics | 1989
Makoto Saito; Ayako Nasu; Shigehiro Kataoka; Katsunori Ohshita; Nobuyuki Yamaji
Archive | 1996
Mamoru Kikuchi; Katsuko Matsuura; Ayako Nasu; Riichiro Uchida; Jun Yamakoshi; Nobuyuki Yamatsugu; 理一郎 内田; 信幸 山次; 純 山越; 克子 松浦; 護 菊地; 綾子 那須
Chemical & Pharmaceutical Bulletin | 1991
Makoto Saito; Shigehiro Kataoka; Ayako Nasu; Nobuyuki Yamaji; Atsushi Ichikawa
