Aydan Dag
Istanbul Technical University
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Featured researches published by Aydan Dag.
Polymer Chemistry | 2010
Aydan Dag; Hakan Durmaz; Volkan Kirmizi; Gurkan Hizal; Umit Tunca
As a new synthetic route, we here employed sequential double click reactions involving azide–alkyne and Diels–Alder reactions for the preparation of multi-miktoarm star block copolymers by using the arm-first approach.
Toxics | 2017
Fatemeh Bahadori; Hayat Onyuksel; Aydan Dag; Gülaçtı Topçu
Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations of chemotherapeutics currently consist of SAS. According to our knowledge, a specific toxicity comparison based on material differences has not yet been performed. The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM) made of a lipid-based amphiphilic distearoyl-sn-glycero-phosphatidylethanolamine-polyethylene glycol (PEG)-2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and PEG. The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using Sulforhodamine-B, WST-1, Acridine Orange/Ethidium Bromide and alkaline single-cell gel electrophoresis assays. Results showed that SSM in conc. of 40 mg/mL shows very low cytotoxicity at the end of 24, 48 and 72 h. The DNA damage caused by SSM was much lower than PM while the latter one showed significant toxicity by causing apoptosis with the ED50 value of 3 mg/mL. While the DNA damage caused by SSM was ignorable, some DNA chain breaks were detected on cells treated with PM.
Macromolecules | 2007
Hakan Durmaz; Aydan Dag; Ozcan Altintas; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2008
Aydan Dag; Hakan Durmaz; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2008
Aydan Dag; Hakan Durmaz; Emrah Demir; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2008
Hakan Durmaz; Aydan Dag; Alp Hizal; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2009
Aydan Dag; Hakan Durmaz; Umit Tunca; Gurkan Hizal
Journal of Polymer Science Part A | 2010
Hakan Durmaz; Aydan Dag; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2011
Aydan Dag; Hatice Sahin; Hakan Durmaz; Gurkan Hizal; Umit Tunca
Journal of Polymer Science Part A | 2009
Aziz Gozgen; Aydan Dag; Hakan Durmaz; Okan Sirkecioglu; Gurkan Hizal; Umit Tunca