Ayşegül Turan

A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and Bowen's disease: a therapeutic challenge.

Epidermodysplasia verruciformis (EV) is a very rare and chronic disease characterized by a susceptibility to cutaneous infections by a group of phylogenetically related human papillomavirus (HPV) types. We present here a 52‐year‐old man previously diagnosed and treated as squamous cell carcinoma but also found to have epidermodysplasia verruciformis lesions in association with Bowens disease. The patient was effectively treated with a combination of interferon therapy (6 million units, twice a week) and topical imiquimod for Bowens disease (five times a week). We conclude that topical imiquimod is very effective in the treatment of Bowens disease and may be combined with systemic interferon therapy in rare cases with multiple vivid presentations of HPV infections.

Parry–Romberg syndrome associated with borreliosis: could photochemotherapy halt the progression of the disease?

Parry–Romberg syndrome (PRS) or progressive hemifacial atrophy is a rare entity characterized by unilateral atrophy of the skin, subcutaneous tissue and sometimes bone and cartilage. Although this syndrome has overlapping features of scleroderma ‘en coup de sabre’, it shows little or no sclerosis and may affect the entire distribution of the trigeminal nerve including the eye and tongue. As the pathogenesis is unknown, no effective therapy exists. We present here the third case of PRS associated with borreliosis and more interestingly two cases whose progressive course have been stabilized with gel PUVA therapy.

A case of generalized granuloma annulare with myelodysplastic syndrome: successful treatment with systemic isotretinoin and topical pimecrolimus 1% cream combination

© 2006 The Authors 693 JEADV 2007, 21, 681–721 Journal compilation

Treatment of infiltrating basal cell carcinoma with the combination of intralesional IFNα‐2b and topical imiquimod 5% cream

References 1 Packer RH, Fields JP, King LE Jr. Granuloma annulare in herpes zoster scars. Cutis 1984; 34: 177–179. 2 Fischer G, Jaworski R. Granuloma formation in herpes zoster scars. J Am Acad Dermatol 1987; 16: 1261–1263. 3 Guill MA, Goette DK. Granuloma annulare at sites of healing herpes zoster. Arch Dermatol 1978; 114: 1383. 4 Schena D, Barba A, Chieregato C. Granulomatous folliculitis as a manifestation of post-herpetic isotopic response. J Eur Acad Dermatol Venereol 2001; 15: 473–475. 5 Wolf R, Brenner S, Ruocco V, et al. Isotopic response. Int J Dermatol 1995; 34: 341–348. 6 Ruocco V, Ruocco E, Ghersetich I, et al. Isotopic response after herpesvirus infection: an update. J Am Acad Dermatol 2002; 46: 90–94. 7 Author Rongioletti F, Ghigliotti G, De Marchi R, et al. Cutaneous mucinoses and HIV infection. Br J Dermatol 1998; 139: 1077–1080. 8 Magro CM, Dawood MR, Crowson AN. The cutaneous manifestations of human parvovirus B19 infection. Hum Pathol 2000; 31: 488–497.

Premature sebaceous hyperplasia with pre-pubertal onset.

of thyroid cancer; metastases occur more frequently in lymph nodes and less often in the lung and bone. Cutaneous metastases from papillary thyroid carcinoma are extremely rare; this is the first case report of the cutaneous metastasis of papillary thyroid carcinoma that developed on the site of incision for thyroidectomy. Most cutaneous metastases in a surgical scar occur as a result of the implantation of tumor cells or direct extension during surgery and usually appear within a year of surgery. The present patient is unusual because the interval between thyroidectomy and the development of cutaneous metastasis to the operation scar was five years. Several mechanisms for the occurrence of cutaneous metastasis from internal malignancy have been proposed, including direct extension, hematogenous spread, lymphatic spread, and the implantation of exfoliated tumor cells during surgery. Tumor cell implantation during surgery may be the most likely pathogenesis of metastasis to a surgical scar. However, in the present case, this is less likely because systemic metastases had been detected three years prior to the development of the skin lesion, and the period between the thyroidectomy and the cutaneous metastasis extended to five years. Alternatively, an alteration in local lymphatic drainage in the region of the scar may be the mechanism responsible for tumor cell implantation. Although hematogenous metastasis is possible, why the metastasis occurred in the scar rather than elsewhere remains open to question. Assuming that this was not a random phenomenon, we suggest that there is a predilection for metastasis to occur at an operation scar as a result of an alteration in the microscopic anatomy around the scar, including in the lymphatic channels, or because the local environment of the scar is more susceptible to metastatic tumor cells. It is possible that this may reflect an altered adhesion molecule profile or altered local immunosurveillance mechanisms. In conclusion, although the exact pathogenesis of metastasis remains unknown, we report this case of a papillary thyroid carcinoma metastasis on a thyroidectomy scar on the neck as representing an interesting occurrence. Ji Hae Lee, MD Kyoung Eun Jung, MD Hei Sung Kim, MD Jun Young Lee, MD Hyung Ok Kim, MD Young Min Park, MD Department of Dermatology Seoul St. Marys Hospital College of Medicine Catholic University of Korea Seoul South Korea

Acquired bilateral nevoid telangiectasia syndrome with gastrointestinal involvement

ejd.2011.1404 Auteur(s) : Aysegul Turan1 draysegulgocer@yahoo.com, Hayriye Saricaoglu1, Emel Bulbul Baskan1, Murat Keskin2, Saduman Balaban Adim3, Hakan Turan4, Sukran Tunali1 1 Uludag University Medical Faculty, Dermatology Department, Bursa, Turkey 2 Uludag University Medical Faculty, Gastroenterology Department, Bursa, Turkey 3 Uludag University Medical Faculty, Pathology Department, Bursa, Turkey 4 Duzce University Medical Faculty, Dermatology Department, Duzce, Turkey Unilateral nevoid telangiectasia [...]