Ayşen Bingöl

Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency

Abstract:  Defects in the interleukin 12 (IL‐12)/interferon gamma (IFN‐γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL‐12 receptor beta 1 (IL‐12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL‐12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.

A Patient With Coexistent Type 1 Diabetes Mellitus and ANCA-Negative Granulomatosis With Polyangiitis

158 ranulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis (WG) is a necrotizing vasculitis involving small and medium sized vessels with the formation of non-caseified granulomas in involved organs.1 It represents a systemic disease that may affect many organ systems together with formation of granulomatous inflammation, although upper-lower respiratory tract and renal involvement are typical for this disorder.2 In this report, we describe a child with type 1 diabetes mellitus who was diagnosed with GPA based on respiratory signs and symptoms. The coexistence of these two conditions has never been reported in our country. A Patient with Coexistent Type 1 Diabetes Mellitus and ANCA-Negative Granulomatosis with Polyangiitis

Diagnostic Dilemma in Allergy and Coronary Syndromes: Kounis Syndrome or Adrenaline Effect?

Öz DOI: 10.4274/cayd.83097 J Pediatr Emerg Intensive Care Med 2018;5:25-30 Ebru Atike Ongun1, Nilgün Erkek2, Fırat Kardelen3, Ayşen Bingöl4, Oğuz Dursun1 1Akdeniz University Faculty of Medicine, Division of Pediatric Critical Care, Antalya, Turkey 2Akdeniz University Faculty of Medicine, Division of Pediatric Emergency Care Medicine, Antalya, Turkey 3Akdeniz University Faculty of Medicine, Division of Pediatric Cardiology, Antalya, Turkey 4Akdeniz University Faculty of Medicine, Division of Pediatric Allergy and Immunology, Antalya, Turkey Case Report / Olgu Sunumu Address for Correspondence/Yazışma Adresi: Ebru Atike Ongun MD, Akdeniz University Faculty of Medicine, Division of Pediatric Critical Care, Antalya, Turkey E-mail: ebruongun@akdeniz.edu.tr ORCID ID: orcid.org/0000-0002-1248-8635 Received/Geliş Tarihi: 26.07.2017 Accepted/Kabul Tarihi: 03.09.2017 Presented at XIII. Pediatric Emergency Care and Pediatric Critical Care Congress, 2016, İzmir, Turkey Copyright 2018 by Society of Pediatric Emergency and Intensive Care Medicine Journal of Pediatric Emergency and Pediatric Intensive Care published by Galenos Yayınevi.

Normal sweat chloride test does not rule out cystic fibrosis

Başaran AE, Karataş-Torun N, Maslak İC, Bingöl A, Alper ÖM. Normal sweat chloride test does not rule out cystic fibrosis. Turk J Pediatr 2017; 59: 68-70. A 5-month-old patient presented with complaints of fever and cough. He was hospitalized with the diagnosis of bronchopneumonia and pseudo-Bartters syndrome. Patient was further investigated for diagnosis of cystic fibrosis. The chloride (Cl) level in sweat was determined within the normal range (25.1 mmol/L, 20.3 mmol/L). CFTR (Cystic Fibrosis Transmembrane Regulator gene; NM_000492.2) genotyping results were positive for p.E92K; p.F1052V mutations. The patient was diagnosed with cystic fibrosis. In our patient, with features of CF and normal sweat test, mutation analysis was helpful for the diagnosis of cystic fibrosis.

Does atopy affect the course of viral pneumonia

Abstract Background The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. Methods Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild–moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia. Results A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1–2.4), parental asthma (RR: 1.5, 95% CI: 1.1–2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2–2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1–3.5) were more common in the severe pneumonia group. Conclusions When patients with mild–moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children.