B.-C. Wang

Practical aspect of sulfur single-wavelength anomalous scattering phasing

Direct Methods solved in the practice the phase problem for small molecules, but did not play a central role for the evolution of the methods traditionally used in macromolecular crystallography. The joint probability distribution technique has been recently coupled with the ability of treating measurement and model errors, so making Direct Methods competitive with the traditional techniques used for dealing with SIR, MIR, SAD, MAD, SIRAS, MIRAS cases. We describe the first applications of Direct Methods to real cases: the new procedures show a high degree of automatism and efficiency.