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Dive into the research topics where B. Katherine Price is active.

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Featured researches published by B. Katherine Price.


Nature | 2009

Longitudinal unzipping of carbon nanotubes to form graphene nanoribbons

Dmitry V. Kosynkin; Amanda L. Higginbotham; Alexander Sinitskii; Jay R. Lomeda; Ayrat M. Dimiev; B. Katherine Price; James M. Tour

Graphene, or single-layered graphite, with its high crystallinity and interesting semimetal electronic properties, has emerged as an exciting two-dimensional material showing great promise for the fabrication of nanoscale devices. Thin, elongated strips of graphene that possess straight edges, termed graphene ribbons, gradually transform from semiconductors to semimetals as their width increases, and represent a particularly versatile variety of graphene. Several lithographic, chemical and synthetic procedures are known to produce microscopic samples of graphene nanoribbons, and one chemical vapour deposition process has successfully produced macroscopic quantities of nanoribbons at 950 °C. Here we describe a simple solution-based oxidative process for producing a nearly 100% yield of nanoribbon structures by lengthwise cutting and unravelling of multiwalled carbon nanotube (MWCNT) side walls. Although oxidative shortening of MWCNTs has previously been achieved, lengthwise cutting is hitherto unreported. Ribbon structures with high water solubility are obtained. Subsequent chemical reduction of the nanoribbons from MWCNTs results in restoration of electrical conductivity. These early results affording nanoribbons could eventually lead to applications in fields of electronics and composite materials where bulk quantities of nanoribbons are required.


Nature Nanotechnology | 2008

Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications.

Ennio Tasciotti; Xuewu Liu; Rohan Bhavane; Kevin Plant; Ashley D. Leonard; B. Katherine Price; Mark Ming Cheng Cheng; Paolo Decuzzi; James M. Tour; Fredika M. Robertson; Mauro Ferrari

Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion.


Journal of the American Chemical Society | 2009

Antioxidant Single-Walled Carbon Nanotubes

Rebecca Lucente-Schultz; Valerie C. Moore; Ashley D. Leonard; B. Katherine Price; Dmitry V. Kosynkin; Meng Lu; Ranga Partha; Jodie L. Conyers; James M. Tour

Single-walled carbon nanotubes (SWCNTs) and ultrashort SWCNTs (US-SWCNTs) were functionalized with derivatives of the phenolic antioxidant, butylated hydroxytoluene (BHT). By using the oxygen radical absorbance capacity (ORAC) assay, the oxygen radical scavenging ability of the SWCNT antioxidants is nearly 40 times greater than that of the radioprotective dendritic fullerene, DF-1. In addition, ORAC results revealed two divergent trends in the antioxidant potential of SWCNTs, depending on the type of functionalization employed. When existing pendant sites on US-SWCNTs were further functionalized by either covalent or noncovalent interactions of the existing pendant sites with a BHT derivative, the amount of BHT-derivative loading proportionately increased the overall antioxidant activity. If, however, functionalization occurred via covalent functionalization of a BHT-derivative directly to the SWCNT sidewall, the amount of BHT-derivative loading was inversely proportional to the overall antioxidant activity. Therefore, increasing the number of pendant sites on the SWCNT sidewalls by covalent functionalization led to a concomitant reduction in ORAC activity, suggesting that the nanotube itself is a better radical scavenger than the BHT-derivatized SWCNT. Cytotoxicity assays showed that both nonfunctionalized and BHT-derivatized SWCNTs have little or no deleterious effect on cell viability. Therefore, SWCNTs may be attractive agents for antioxidant materials and medical therapeutics research.


ACS Nano | 2010

Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified Paclitaxel.

Jacob M. Berlin; Ashley D. Leonard; Tam T. Pham; Daisuke Sano; Daniela C. Marcano; Shayou Yan; Stefania Fiorentino; Zvonimir L. Milas; Dmitry V. Kosynkin; B. Katherine Price; Rebecca Lucente-Schultz; Xiaoxia Wen; M. Gabriela Raso; Suzanne L. Craig; Hai T. Tran; Jeffrey N. Myers; James M. Tour

Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mixed with paclitaxel. This formulation of PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) is stable for at least 20 weeks. The PTX/PEG-HCCs formulation was as effective as PTX in a clinical formulation in reducing tumor volumes in an orthotopic murine model of oral squamous cell carcinoma. Preliminary toxicity and biodistribution studies suggest that the PEG-HCCs are not acutely toxic and, like many other nanomaterials, are primarily accumulated in the liver and spleen. This work demonstrates that carbon nanomaterials are effective drug delivery vehicles in vivo when noncovalently loaded with an unmodified drug.


Journal of Nanomaterials | 2009

Vapor Sensing Using Conjugated Molecule-Linked Au Nanoparticles in a Silica Matrix

Shawn M. Dirk; Stephen W. Howell; B. Katherine Price; Hongyou Fan; Cody M. Washburn; David R. Wheeler; James M. Tour; Joshua Whiting; R. Joseph Simonson

Cross-linked assemblies of nanoparticles are of great value as chemiresistor-type sensors. Herein, we report a simple method to fabricate a chemiresistor-type sensor that minimizes the swelling transduction mechanism while optimizing the change in dielectric response. Sensors prepared with this methodology showed enhanced chemoselectivity for phosphonates which are useful surrogates for chemical weapons. Chemoselective sensors were fabricated using an aqueous solution of gold nanoparticles that were then cross-linked in the presence of the silica precursor, tetraethyl orthosilicate with the -, -dithiolate (which is derived from the in situ deprotection of 1,4-di(Phenylethynyl-,-diacetylthio)-benzene (1) with wet triethylamine). The cross-linked nanoparticles and silica matrix were drop coated onto interdigitated electrodes having 8 m spacing. Samples were exposed to a series of analytes including dimethyl methylphosphonate (DMMP), octane, and toluene. A limit of detection was obtained for each analyte. Sensors assembled in this fashion were more sensitive to dimethyl methylphosphonate than to octane by a factor of 1000.


Journal of the American Chemical Society | 2006

Single Wall Carbon Nanotube Amplification: En Route to a Type-Specific Growth Mechanism

Richard E. Smalley; Yubao Li; Valerie C. Moore; B. Katherine Price; Ramon Colorado; Howard K. Schmidt; Robert H. Hauge; and Andrew R. Barron; James M. Tour


Journal of the American Chemical Society | 2006

Functionalization of single-walled carbon nanotubes "on water".

B. Katherine Price; James M. Tour


Journal of the American Chemical Society | 2005

Green Chemical Functionalization of Single-Walled Carbon Nanotubes in Ionic Liquids

B. Katherine Price; and Jared L. Hudson; James M. Tour


Chemistry of Materials | 2009

Mechanically Assisted Exfoliation and Functionalization of Thermally Converted Graphene Sheets

Zhong Jin; Jay R. Lomeda; B. Katherine Price; Wei Lu; Yu Zhu; James M. Tour


Chemistry of Materials | 2007

Repetitive Functionalization of Water-Soluble Single-Walled Carbon Nanotubes. Addition of Acid-Sensitive Addends

Jason J. Stephenson; Jared L. Hudson; Ashley D. Leonard; B. Katherine Price; James M. Tour

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Hai T. Tran

University of Texas MD Anderson Cancer Center

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Jacob M. Berlin

City of Hope National Medical Center

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Jeffrey N. Myers

University of Texas MD Anderson Cancer Center

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M. Gabriela Raso

University of Texas MD Anderson Cancer Center

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