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Featured researches published by B P Herring.


Hypertension | 1991

Vascular smooth muscle contractile elements. Cellular regulation.

James T. Stull; P J Gallagher; B P Herring; Kristine E. Kamm

For many years the simple view was held that contractile force in smooth muscle was proportional to cytosolic Ca2+ concentrations ([Ca2+],). With the discovery that phosphorylation of myosin light chain by Ca2+/calmodulin-dependent myosin light chain kinase initiated contraction, regulation of the contractile elements developed more complex properties. Molecular and biochemical investigations have identified important domains of myosin light chain kinase: light chain binding sites, catalytic core, pseudosubstrate prototope, and calmodulin- binding domain. New protein phosphatase inhibitors such as okadaic acid and calyculin A should help in the identification of the physiologically important phosphatase and potential modes of regulation. The proposal of an attached, dephosphorylated myosin cross bridge (latch bridge) that can maintain force has evoked considerable controversy about the detailed functions of the myosin phosphorylation system. The latch bridge has been defined by a model based on physiological properties but has not been identified biochemically. Thin-filament proteins have been proposed as secondary sites of regulation of contractile elements, but additional studies are needed to establish physiological roles. Changes in the Ca2+ sensitivity of smooth muscle contractile elements with different modes of cellular stimulation may be related to inactivation of myosin light chain kinase or activation of protein phosphatase activities. Thus, contractile elements in smooth muscle cells are not dependent solely on [Ca2+], but use additional regulatory mechanisms. The immediate challenge is to define their relative importance and to describe molecular-biochemical properties that provide insights into proposed physiological functions.


Journal of Biological Chemistry | 1991

Molecular Characterization of a Mammalian Smooth Muscle Myosin Light Chain Kinase

P J Gallagher; B P Herring; S. A. Griffin; James T. Stull


Journal of Biological Chemistry | 1991

The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin

P J Gallagher; B P Herring


Journal of Biological Chemistry | 1993

A molecular mechanism for autoinhibition of myosin light chain kinases.

P J Gallagher; B P Herring; A Trafny; J Sowadski; James T. Stull


Journal of Biological Chemistry | 1990

Domain characterization of rabbit skeletal muscle myosin light chain kinase

B P Herring; James T. Stull; P J Gallagher


Progress in Clinical and Biological Research | 1990

Myosin phosphorylation in smooth and skeletal muscles: regulation and function.

James T. Stull; B. F. Bowman; P. J. Gallagher; B P Herring; Li Hsu; Kristine E. Kamm; Y. Kubota; S. A. Leachman; H. L. Sweeney; Malú G. Tansey


Journal of Biological Chemistry | 1992

Substrate specificity of myosin light chain kinases.

B P Herring; P J Gallagher; James T. Stull


Journal of Biological Chemistry | 1995

Photoaffinity Labeling of a Peptide Substrate to Myosin Light Chain Kinase

Zhong-Hua Gao; Gang Zhi; B P Herring; Carolyn R. Moomaw; L. Deogny; Clive A. Slaughter; James T. Stull


Journal of Biological Chemistry | 1990

Acidic residues comprise part of the myosin light chain-binding site on skeletal muscle myosin light chain kinase

B P Herring; D P Fitzsimons; James T. Stull; P J Gallagher


American Journal of Physiology-cell Physiology | 1989

Molecular characterization of rat skeletal muscle myosin light chain kinase

B P Herring; M. H. Nunnally; P J Gallagher; James T. Stull

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James T. Stull

University of Texas Southwestern Medical Center

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P J Gallagher

University of Texas Southwestern Medical Center

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Kristine E. Kamm

University of Texas Southwestern Medical Center

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S. A. Griffin

University of Texas Southwestern Medical Center

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A Trafny

University of California

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B. F. Bowman

University of Texas Southwestern Medical Center

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Carolyn R. Moomaw

University of Texas Southwestern Medical Center

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Clive A. Slaughter

University of Texas Southwestern Medical Center

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D P Fitzsimons

University of Texas Southwestern Medical Center

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Gang Zhi

University of Texas Southwestern Medical Center

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