B.S. Trembly

Combined microwave heating and surface cooling of the cornea

The authors investigated a nonsurgical means of reshaping the cornea to correct hyperopia, keratoconus, or myopia. The object was to heat the central stroma of the cornea to the shrinkage temperature of collagen, 55-58 degrees C. The heating device was an open-ended, coaxial, near-field applicator driven at 2450 MHz; it incorporates cooling of the cornea surface by slow of saline. The system was investigated theoretically by computing the 2-D, axisymmetric temperature distribution with the finite-element method. The system was investigated experimentally by heating excised steer corneas. Histology showed that the system could shrink the stroma to a depth of 0.6 mm while sparing the epithelium in 75% of the cases; the diameter of shrinkage was 1.3 mm. Theory predicted a significantly deeper and narrower region of shrinkage than was observed.<<ETX>>

SAR Patterns from an Interstitial Microwave Antenna-Array Hyperthermia System

In recent years, a number of groups have been investigating the use of interstitial microwave antenna-array hyperthermia (IMAAH) systems for the treatment of superficial and deep-seated tumors. A critical parameter in any hyperthermia system is the SAR (specific absorption rate) pattern, which gives information about the energy absorption in the tumor and surrounding tissue. In this paper, we compare the theoretical and measured values of the SAR distribution for an array of four 915-MHz antennas implanted on the corners of a 2-cm square array. The overall length of the antennas was assumed to be 7 cm theoretically and was either 6 or 7 cm for the measurements. In general, there was good agreement between the theoretical predictions and the experimental results. In particular, both theory and experiment demonstrated that the maximum SAR occurred in the junction plane of the antenna array and at the center of the square array. Similarly, both showed that the Iongitudinal extent of the heating pattern is about 5 cm for a single antenna, but closer to 3 cm for an array where the Iongitudinal extent is defined by the length in the longitudinal direction where the SAR is greater than 50 percent of the maximum. The experiments showed that the SAR patterns were quite reproducible, and that the use of double stub tuners to minimize the reflected power for each antenna resulted in poorer SAR patterns due to phase variations created by the tuners. However, the use of an attenuator with each antenna to equalize the maximum SAR from each antenna did improve the SAR distributions slightly.

SAR distributions for 915 MHz interstitial microwave antennas used in hyperthermia for cancer therapy

Theoretical and experimental specific absorption rate (SAR) distributions are presented for single insulated antennas operating at 915 MHz in muscle phantom; the SAR is deduced from measured temperature rise. Results show that dipoles with lengths much shorter than their resonant length have a characteristically large reactive input impedance component and a substantially smaller absolute SAR magnitude than resonant dipoles. All cases investigated demonstrate that the maximum SAR occurs near the junction, regardless of insertion depth. Experimental results show that an antenna with the tip section equal to a quarter-wavelength and the insertion depth equal to a half-wavelength achieves a substantial increase in the longitudinal power distribution compared to other antenna designs that were evaluated.<<ETX>>

Control of the SAR Pattern Within an Interstitial Microwave Array through Variation of Antenna Driving Phase

The interstitial microwave antenna-array hyperthermia (IMAAH) system produces a pattern of specific absorption rate (SAR) that is nonuniform within a 2-cm square array driven in phase at 915 MHz. Theory and experiment show that the point of phase coherence (maximum SAR) can be shifted to a point where the SAR is small by changing the antenna driving phases. Rapid shifting makes the time-average SAR more uniform in the direction perpendicular to the antennas. In 95 percent of the antenna junction plane, the time-average SAR is constant within 10 percent.

Theoretical and experimental SAR distributions for interstitial dipole antenna arrays used in hyperthermia

Theoretical predictions and experimental measurements of power deposition in muscle tissue phantoms are compared for various arrays of microwave dipole antennas used for hyperthermia cancer therapy. The antennas are linear coaxial dipoles which are inserted into small nylon catheters implanted in the tumor volume. The specific absorption rate (SAR) patterns for a 2-cm square array of four 915-MHz antennas are presented for both resonant and nonresonant dipoles. Arrays of dipoles with lengths much shorter than the resonant half-wavelength have a far more reactive input impedance and a much smaller absolute SAR magnitude in the array center than is seen for arrays of resonant dipoles, and the maximum SAR shifts from the array center to the antenna surfaces. The absolute length of the volume heated by the small-diameter antennas with the longer half-wavelength was longer than that of the larger-diameter antennas. SAR distributions for 4-cm square arrays of eight and nine antennas fed with equal amplitude and phase are also compared. It is shown that much of the array volume has a power deposition less than 25% of the maximum SAR and that the distribution is nonuniform for both the eight- and nine-antenna configurations. >

The effect of air cooling on the radial temperature distribution of a single microwave hyperthermia antenna in vivo

Canine skeletal muscle was heated with a single microwave antenna within a brachytherapy catheter driven at 2000 MHz. The radial, steady-state temperature distribution was measured with and without air cooling of the antenna, as produced by room temperature air flowing in the catheter at 7.5 l/min. The axial temperature distribution was also measured with air cooling. In the antenna junction plane the area heated to a given temperature increased by a factor of four with air cooling when the same antenna temperature was enforced. With the same maximum temperature enforced, the area would increase by a factor of 2.5 with air cooling. The axial temperature distribution was not compromised by air cooling.

Comparison of power deposition by in-phase 433 MHz and phase-modulated 915 MHz interstitial antenna array hyperthermia systems

The interstitial microwave antenna array hyperthermia (IMAAH) system produces a pattern of specific absorption rate (SAR) that is nonuniform within a 2-cm square array when driven in phase at 915 MHz. It was found that phase modulation makes the time-averaged SAR pattern significantly more uniform in planes perpendicular to the antennas. To drive antennas in phase at 433 MHz similarly improves SAR uniformity when the antennas are of resonance length. >

Effect of phase modulation on the temperature distribution of a microwave hyperthermia antenna array in vivo.

Perfused, canine skeletal muscle and the brain tumour of a cancer patient were heated with an array of four parallel, interstitial antennas placed on the corners of a 2-cm square and driven at 915 MHz. The temperature distributions along the axial and diagonal catheters were measured with equal-phase driving of the antennas and with several time-varying schemes of driving phase differences among the antennas. When equal-phase driving was replaced by a rotating scheme of 90 degrees driving phase differences, the tissue area in the junction plane heated above a normalized index temperature of 0.6 increased by a factor of about 1.25. With a rotating phase of 135 degrees, the same area increased by a factor of about 1.6. The axial temperature distribution was not affected significantly by driving phase.

Theoretical and experimental analysis of air cooling for intracavitary microwave hyperthermia applicators

An intracavitary microwave antenna array system has been developed and tested for the hyperthermia treatment of prostate cancer at Thayer School of Engineering and Dartmouth-Witchcock Medical Center. The antenna array consists of a choked dipole antenna inserted into the urethra and a choked dipole antenna eccentrically embedded in a Teflon obturator inserted into the rectum. To prevent unnecessary heating of the healthy tissue that surrounds each applicator, an air cooling system has been incorporated into the rectal applicator. The air cooling system was designed and modeled theoretically using a numerical solution of heat and momentum equations within the applicator, and an analytical solution of the Pennes bioheat equation in tissue surrounding the applicator. The 3D temperature distribution produced by the air-cooled rectal applicator was measured in a perfused canine prostate.<<ETX>>

Pattern of response to interstitial hyperthermia and brachytherapy for malignant intracranial tumour: a CT analysis.

Interstitial microwave hyperthermia in combination with iridium-192 brachytherapy has been administered to 23 cases of malignant brain tumours in a phase one clinical trial to assess the feasibility and safety of this treatment. In order to quantify the acute and long-term response of tumour and surrounding brain to this treatment, a morphometric computed tomography scan analysis was performed in 18 evaluable patients. Volumes defined by the outer margin of the contrast-enhancing rim, by the hypodense necrotic region within the enhancing rim and by the surrounding hypodensity region were calculated from computer measurements. Hyperthermia equipment performance (HEP) was calculated for the evaluation of heating. After the treatments, the volume of the inner hypodensity region decreased in seven patients and the volume increased in 11 patients. In five patients, the outer margin of the contrast-enhancing lesion showed an initial increase in volume followed by a decrease and in these patients higher HEP and longer survival were observed significantly. The volume of the surrounding hypodensity region varied following treatments, but in most instances, the region subsequently increased in the interval immediately prior to death. Contribution of heat effect to these changes are discussed and the significance of aggressive heating, which provides transient opening of blood brain barrier, is shown.