B. Wolf

Intelligent Mobile Lab for Metabolics in Environmental Monitoring

Abstract The flexible and modular setup of an intelligent mobile lab (IMOLA) that can be equipped with biosensor chips for monitoring of cellular metabolism is described. An application as an environmental monitoring system is described by recording the extracelluar acidification and cellular respiration of Chlorella kessleri after exposure to the herbicide metamitron. The adaptability of the IMOLA system to future developments in the field of biosensors or cellular metabolism analysis is emphasized.

Cellular Assays with Multiparametric Bioelectronic Sensor Chips

During recent years, sensor chip-based systems have been developed which monitor functional changes of living cells. Key elements of such cellular assays are silicon or glass chips with integrated sensors for physicochemical parameters, i.e. pH, pO 2 . electric impedance and temperature. Analysis of these primary parameters yields information about cell metabolism, cell growth and adhesion, and cell morphological changes. The operation principles of individual sensor types are described together with examples of experimental results.

Cellular signaling: aspects for tumor diagnosis and therapy.

Abstract Cells are organic microsystems with functional compartments interconnected by complex signal chains. Intracellular signaling routes and signal reception from the extracellular environment are characterized by redundancy, i.e., parallel pathways exist. If a cell is exposed to an external “signal input”, the signal processing elements within the cell provide a response that will be a pattern of reactions manifest as a metabolic, morphologic or electric “signal output”. Cell-chip hybrid structures are miniaturized analytical systems with the capability to monitor such cell responses in real time and under continuous control of the environmental conditions. A system analysis approach gives an idea of how the biological component of these hybrid structures works. This is exemplified by the putative role of the microenvironmental pH as a parameter of the utmost importance for the malignant “mode” of tumor cells, which can be monitored and modeled on such hybrid structures.

Home care: A telematic rehabilitation exerciser

This paper deals with the development of a system established on a telematic rehabilitation exerciser, a plug-PC and a real-time web-animation. An easy to use device, which allows a telematically controlled training at home is target of this project. It is thereby based on the diagnosis and therapy platform COMES® of the Heinz Nixdorf-Lehrstuhl für Medizinische Elektronik of the Technische Universität München. In COMES® mobile measured vital parameters are intelligently evaluated by an expert system before they are provided to the user along with medical information and trends. A Java application allows the real-time data, which is sent by a telematic exerciser and received over the Bluetooth interface of the plug-PC to be filtered and transmitted over a SQL-connection on, to a database. These data is retrieved by the animation and evaluated in form of a game. To visualize this web-animation, the screen of a potential terminal device is splitted in two and taking only a small horizontal part, this animation is shown on the screen. The other part could be filled by a TV-programm, Video or Skype window depending on the abilities of the terminal device which could be any device with an internet browser (e.g. a Smart TV).