Babak Nasr

Electrical resistivity of nanocrystalline Al-doped zinc oxide films as a function of Al content and the degree of its segregation at the grain boundaries

Highly transparent and conducting Al-doped ZnO (AZO) films are prepared via sol-gel method with a broad range of nominal Al-doping. The film porosity and morphology is determined by the rate of temperature ramping during the drying of the gel phase. The minimum resistivity is observed to occur around 1.5–2 at. % Al-doped films, irrespective of the morphology and microstructure. It is found by local chemical analysis that Al tends to segregate at the grain boundaries and above a critical concentration, the segregated Al starts to dominate the electronic transport in nanocrystalline AZO. The optical measurements corroborate these findings showing a systematic increase in carrier density only up to 1.5–2 at. % Al-doping. It is concluded that the presence of the resistivity minimum is not merely determined by a solubility limit but is a result of the interplay between the changing carrier concentration and carrier scattering at the segregated Al.

Solution-processed oxide semiconductor SnO in p-channel thin-film transistors

A p-type inorganic oxide semiconductor, tin monoxide (SnO), is developed by a solution process. SnO thin-film transistors (TFTs) in the p-channel enhancement mode are fabricated by spin-coating a precursor solution followed by postannealing, showing a highest field-effect mobility of 0.13 cm2 V−1 s−1, threshold voltage of −1.9 V, and on/off drain current ratio of 85.

Vertical Nanowire Electrode Arrays as Novel Electrochemical Label‐Free Immunosensors

A new method for the fabrication of a label-free electrochemical immunosensor based on vertical nanowires (VNWs) is proposed. The VNWs are functionalized to detect antibodies against a major astrocytic structural protein component, glial fibrillary acidic protein (GFAP). It is revealed that the interaction of GFAP-antibody with functionalized VNWs leads to a clear change in device conductance and the corresponding capacitance.

Temperature tolerance study of high performance electrochemically gated SnO2 nanowire field-effect transistors

Electrochemically gated field-effect transistors are fabricated with single crystalline SnO2 nanowires as a transistor channel. Excellent transistor performance and a very low-voltage operation (≤2 V) have been demonstrated. Thermal stability of the FETs is systematically examined up to 180 °C; while unchanged transistor characteristics are obtained up to 70 °C; short exposure at 110 °C is also found permissible, making such devices compatible to be integrated directly to organic photovoltaics or to various biomedical appliances.

Self-Organized Nanostructure Modified Microelectrode for Sensitive Electrochemical Glutamate Detection in Stem Cells-Derived Brain Organoids

Neurons release neurotransmitters such as glutamate to communicate with each other and to coordinate brain functioning. As increased glutamate release is indicative of neuronal maturation and activity, a system that can measure glutamate levels over time within the same tissue and/or culture system is highly advantageous for neurodevelopmental investigation. To address such challenges, we develop for the first time a convenient method to realize functionalized borosilicate glass capillaries with nanostructured texture as an electrochemical biosensor to detect glutamate release from cerebral organoids generated from human embryonic stem cells (hESC) that mimic various brain regions. The biosensor shows a clear catalytic activity toward the oxidation of glutamate with a sensitivity of 93 ± 9.5 nA·µM−1·cm−2. It was found that the enzyme-modified microelectrodes can detect glutamate in a wide linear range from 5 µM to 0.5 mM with a limit of detection (LOD) down to 5.6 ± 0.2 µM. Measurements were performed within the organoids at different time points and consistent results were obtained. This data demonstrates the reliability of the biosensor as well as its usefulness in measuring glutamate levels across time within the same culture system.

A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening

The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 µg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems.

Facile fabrication of electrolyte-gated single-crystalline cuprous oxide nanowire field-effect transistors.

Oxide semiconductors are considered to be one of the forefront candidates for the new generation, high-performance electronics. However, one of the major limitations for oxide electronics is the scarcity of an equally good hole-conducting semiconductor, which can provide identical performance for the p-type metal oxide semiconductor field-effect transistors as compared to their electron conducting counterparts. In this quest, here we present a bulk synthesis method for single crystalline cuprous oxide (Cu2O) nanowires, their chemical and morphological characterization and suitability as active channel material in electrolyte-gated, low-power, field-effect transistors (FETs) for portable and flexible logic circuits. The bulk synthesis method used in the present study includes two steps: namely hydrothermal synthesis of the nanowires and the removal of the surface organic contaminants. The surface treated nanowires are then dispersed on a receiver substrate where the passive electrodes are structured, followed by printing of a composite solid polymer electrolyte (CSPE), chosen as the gate insulator. The characteristic electrical properties of individual nanowire FETs are found to be quite interesting including accumulation-mode operation and field-effect mobility of 0.15 cm(2) V(-1) s(-1).

GFAP Antibody Detection Using Interdigital Coplanar Waveguide Immunosensor

Glioma is the most common primary brain tumor with its early detection remaining a challenge. Autoantibodies against glial fibrillary acidic protein (GFAP) have shown the highest differential expression compared with the other glioma expressed autoantibodies. In this paper, an immunosensor to detect GFAP antibody levels is developed using an interdigital coplanar waveguide (ID-CPW). The ID-CPW is fabricated on an SiO2/Si substrate with the CPW and inter-digital electrode conducting layers made using Cr/Au. The sensor is functionalized, and protein extracted from astrocytes is immobilized on the surface. Sensitivity and dynamic range are ascertained using varying the concentrations of a commercial, polyclonal antibody to GFAP. The electrical detection of antigen-antibody binding is performed in both dry and wet environments across the 1-25-GHz range. Our results show that the proposed sensor can detect antibodies to GFAP to a minimum concentration of 2.9 pg/ml with a turnaround time in less than 3 h. Our electrical measurements indicate an improved sensitivity compared with the state-of-the-art optical detection methods. The immunosensor, developed to detect antibody against GFAP, is the first to show the applicability in the detection of glioma using the GFAP autoantibodies.

Graphene foam as a biocompatible scaffold for culturing human neurons

In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.

A Silk Fibroin Bio-Transient Solution Processable Memristor

Today’s electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmentally friendly solution processable memristive crossbar arrays using silk fibroin protein which demonstrated bipolar resistive switching ratio of 104 and possesses programmable device lifetime characteristics before the device gracefully bio-degrades, minimizing impact to environment or to the implanted host. Lactate dehydrogenase assays revealed no cytotoxicity on direct exposure to the fabricated device and support their environmentally friendly and biocompatible claims. Moreover, the correlation between the oxidation state of the cations and their tendency in forming conductive filaments with respect to different active electrode materials has been investigated. The experimental results and the numerical model based on electro-thermal effect shows a tight correspondence in predicting the memristive switching process with various combinations of electrodes which provides insight into the morphological changes of conductive filaments in the silk fibroin films.