Bahaddurghatta E. Kumara Swamy

Electrochemical Sensor for the Determination of Paracetamol at Carbamazepine Film Coated Carbon Paste Electrode

Abstract The electrochemical behavior of paracetamol (PC) was investigated at carbamazepine (CBZ) film coated carbon paste electrode in 0.2 M PBS of pH 7.4 by cyclic voltammetric technique. The modified electrode was exhibited a good electrochemical activity towards the oxidation of paracetamol, which results in a noticeable improvement of the peak currents and feasible oxidation as compared to the bare carbon paste electrode. Under optimal experimental conditions the electrochemical response to PC was linear in the concentration range from 1.0×10−4 M to 3.94×10−4 M with a detection limit of 0.24 μM by cyclic voltammetric technique. The sensitivity, long-term stability, reproducibility was shown by the modified electrode. Finally, the proposed method was successfully applied to determine PC in pharmaceutical samples.

Niacin Film Coated Carbon Paste Electrode Sensor for the Determination of Epinephrine in Presence of Uric Acid: A Cyclic Voltammetric Study

Abstract Voltammetric resolution of neurotransmitter epinephrine (EP) in presence if uric acid (UA) was achieved at niacin film coated carbon paste electrode (niacin/CPE) in 0.2 M PBS of pH 7.4 by cyclic voltammetry (CV) technique. The fabricated electrode remarkably enhanced an electrocatalytic activity towards the oxidation of epinephrine, resulting in the irreversible general 2-electrontransfer adsorption controlled phenomenon. The effect of several experimental parameters were discussed. Such as, scan rate, pH and concentration. Under optimal conditions, the anodic peak current (Ipa) was proportional to epinephrine concentration over the range 20.66-174.4 μM, (r2=0.9976) with a detection limit of 11.3 nM by CV technique. The sensitive, selective and reproducible result obtained at the niacin/CPE. Finally, the developed method was successfully applied for determination of epinephrine in pharmaceutical samples.