Bahar Oc
Selçuk University
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Featured researches published by Bahar Oc.
Heart Surgery Forum | 2007
Meral Kanbak; Fatma Saricaoglu; Seda Banu Akinci; Bahar Oc; Huriye Balci; Bilge Celebioglu; Ülkü Aypar
BACKGROUND Inhalation anesthetics such as isoflurane, sevoflurane, and desflurane are widely used in clinical practice; however, there is no study for comparing these drugs in cardiac surgery with respect to postoperative cognitive outcome and S100 beta protein (S100 BP) levels. In this study, we evaluated the effect of sevoflurane, isoflurane, and desflurane anesthesia on neuropsychological outcome and S100 BP levels in patients undergoing coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). MATERIALS AND METHODS Forty-two male patients were prospectively randomized and classified into 3 groups according to the volatile agents used; isoflurane, sevoflurane, desflurane. All patients had a sufficient education level to participate in neuropsychological testing and a normal carotid Doppler ultrasonography. Blood samples for analysis of S100 BP were collected before anesthesia (T1), before heparinization (T2), 15 minutes into CPB (T3), following protamine administration (T4), postoperatively (T5), 24 hours after the operation (T6), postoperative day 3 (T7), and postoperative day 6 (T8). The neuropsychological tests, including Mini-Mental State Examination (MMSET) and visual-aural digit span test (VADST), were administered 1 day prior to surgery and on the third and sixth postoperative days. RESULTS The postoperative third and sixth day MMSET scores and third day visual-written subtest scores in the sevoflurane group were significantly lower than in the isoflurane and desflurane groups (P < .05). S100 BP levels increased with the beginning of anesthesia in the sevoflurane and desflurane groups. Although S100 BP decreased to baseline levels on postoperative day 1 in the sevoflurane group, this was significantly higher on the third and sixth days postoperatively in the desflurane group (P < .05). In the isoflurane group, the S100 BP level was significantly higher than the baseline level only after CPB (P < .05). CONCLUSION Our study suggests that isoflurane is associated with better neurocognitive functions than desflurane or sevoflurane after on-pump CABG. Sevoflurane seems to be associated with the worst cognitive outcome as assessed by neuropsychologic tests, and prolonged brain injury as detected by high S100 BP levels was seen with desflurane.
Journal of International Medical Research | 2012
Inci Kara; Seza Apiliogullari; Bahar Oc; Jale Bengi Celik; Ates Duman; Çetin Çelik; Nu Dogan
OBJECTIVE: Gynaecological oncological surgery (GOS) includes a wide variety of surgical procedures and postoperative pain is a major concern. This study compared the impact of intrathecal morphine (ITM) plus patient-controlled analgesia (PCA) with PCA alone on morphine consumption, pain relief and patient satisfaction after GOS. METHODS: Sixty women undergoing GOS under general anaesthesia were randomized to receive either 0.3 mg ITM or placebo. On arrival at the postanaesthesia care unit each patient received a morphine PCA pump. The three primary outcome measures were pain, patient satisfaction scores evaluated using a 100-mm visual analogue scale and cumulative PCA morphine consumption. RESULTS: No significant differences were observed in the demographic data. Cumulative PCA morphine consumption was significantly lower in the ITM group compared with the control group. Fatigue scores were lower in the ITM group compared with the control group but did not reach statistical significance. Pain, sedation and patient satisfaction scores, and the rate of side-effects were similar for the two groups. CONCLUSIONS: Administering ITM in GOS could improve postoperative analgesia and reduce morphine consumption without serious side-effects.
Cardiovascular Journal of Africa | 2014
Oguzha Arun; Bahar Oc; Mehmet Oc; Ates Duman
BACKGROUND Peri-operative management of infants with trisomy 18 syndrome is challenging due to various congenital cardiac and facial anomalies. CASE REPORT We report the anaesthetic management of a 13-day-old neonate with 1 540 g body weight, undergoing closure of patent ductus arteriosus and pulmonary artery banding. Anaesthesia was induced with sevoflurane, fentanyl and rocuronium. Despite dysmorphic facial features, ventilation and endotracheal intubation were achieved uneventfully. Anaesthesia was maintained with sevoflurane and fentanyl and was uneventful. The patient was transferred to the neonatal ICU intubated and with ventilatory support. The baby was extubated on the second day postoperatively. CONCLUSION Our knowledge of the proper anaesthetic technique for children undergoing palliative or corrective surgery is limited. Further case reports will increase our experience in peri-operative management of children with trisomy 18.
Pediatric Anesthesia | 2013
Seza Apiliogullari; Bahar Oc; Inci Kara; Derya Çelik; Ates Duman; Hakan Senaran
1. Large clinical trials to study rare thrombotic complications of TXA in children are lacking. More than 90% of TXA is cleared in humans by renal excretion. TXA is a small molecule, and it is expected to be cleared by renal dialysis. 2. Infants with immature renal function and children with significant renal dysfunction might be at higher risk of thrombotic complications with TXA, especially with high doses. 3. In the setting of unknown incidence of rare thrombotic complications and optimal dosing regimen for infants and children, risks, benefits, and alternative therapy to antifibrinolytics need to be discussed and taken into perioperative management decisions.
Renal Failure | 2012
Bahar Oc; Seda Banu Akinci; Meral Kanbak; Eda Satana; Bilge Celebioglu; Ülkü Aypar
Background: There are few data on the effects of anesthesia and cardiopulmonary bypass (CPB) on perioperative renal function in children with cyanotic congenital heart disease undergoing open heart surgery. This study aims to investigate the perioperative renal function in cyanotic versus acyanotic children undergoing sevoflurane anesthesia for open heart surgery. Methods: After receiving ethical committee approval, 12 acyanotic patients (preoperative oxygen saturation: SaO2 > 85%) and 12 cyanotic children (SaO2 < 85%) were included. Sevoflurane was administered at concentration levels of 2% before CPB and 1–2% during CPB after standard anesthesia induction. Inorganic fluoride, electrolytes, creatinine, urea nitrogen in serum and urine samples, and N-acetyl-β-d-glucosaminidase (NAG) in urine samples were measured before induction, before CPB, during CPB, after CPB, at the end of surgery, and at 24th h postoperatively. Results: The levels of serum uric acid levels were higher in the cyanotic group (p < 0.05). There were no differences in the levels of serum creatinine and urine creatinine, urea nitrogen, and electrolytes between the two groups. Serum inorganic fluoride levels were always higher in the acyanotic group than in the cyanotic group, but these differences between the groups reached statistical significance at two measurement times (before CPB and end of surgery) (p < 0.05). Urinary inorganic fluoride levels increased with time in both groups. Although urinary NAG increased significantly after the CPB in the cyanotic group, the differences between the two groups did not reach statistical significance. Conclusions: We have concluded that renal function was not affected during open heart surgery with sevoflurane anesthesia, in both cyanotic and acyanotic children.
Journal of Obstetrics and Gynaecology Research | 2015
Ergun Gunduz; Oguzhan Arun; Sengal Taylan Bagci; Bahar Oc; Alper Salman; Setenay Arzu Yılmaz; Çetin Çelik; Ates Duman
To assess the effects of propofol and sevoflurane on the contraction elicited by dopamine, adrenaline and noradrenaline on isolated human umbilical arteries.
Arsiv Kaynak Tarama Dergisi | 2014
Bahar Oc; Oguzhan Arun; Murat Öncel; Ates Duman
Yabanci cisim aspirasyonlari cocukluk doneminin gercek acil vakalari arasinda yer almaktadir. Mortalite ve morbidite oranlari girisim oncesi cocugun klinige basvurusunda var olan semptomlari ile dogrudan iliskilidir. Anestezi uygulamasinda kardiyopulmoner arrestten, sadece yabanci cisim aspirasyonu hikayesi olmayan hafif respiratuar semptomlara kadar degisen klinikle karsimiza gelebilirler. Tani haftalar ya da aylar boyunca konamayabilir ve ortaya cikan akciger problemi kotulesebilir. Tani asamasinda oncelikle akciger filmi ya da yuksek cozunurluklu bilgisayarli tomografiden yararlanilmaktadir. Bronkoskopi, cesitli anestezi yontemleri ile birlikte tani konulmasi, taninin dogrulanmasi hem de yabanci cismin havayolundan cikarilmasinda kullanilmaktadir. Anesteziye bagli mortalite ve morbiditenin azaltilmasi yonunde uygulanacak anestezi yontemi konusunda ortak bir gorus bulunmamasina ragmen her gecen yil anestezi alaninda kaydedilen farmakolojik ve teknik ilerlemelerle mortalite ve morbiditede anlamli duzeyde azalma izlenmektedir. Uygulanacak ventilasyon modlari ve anestezi yontemi bronkoskopist ve anestezistin isbirligi ile uyumuna baglidir. Bu derlemede cocuklardaki yabanci cisim obstruksiyonlarindaki anestezi yonetimine ait ozelliklerin sunulmasi amaclanmistir.
International Journal of Medical Sciences | 2011
Gülperi Çelik; Bahar Oc; Inci Kara; Mümtaz Yılmaz; Ali Yuceaktas; Seza Apiliogullari
Middle East journal of anaesthesiology | 2006
Fatma Saricaoglu; Seda Banu Akinci; Bahar Oc; Meral Kanbak; Akbulut B; Bilge Celebioglu
Annals of Thoracic and Cardiovascular Surgery | 2014
Oguzhan Arun; Bahar Oc; Ates Duman; Serkan Yildirim; Murat Simsek; Bora Farsak; Mehmet Oc