Bahram Khoobehi

Intravitreal Liposome-encapsulated Triofluorothymidine in a Rabbet Model

Two groups of albino rabbits received an intravitreal injection of liposome-encapsulated trifluorothymidine. One group underwent a clearance study using high-performance liquid chromatography. The results of this study demonstrated a prolonged vitreal drug level within the range of ID50 for many strains of herpesvirus and human cytomegalovirus (CMV) at 28 days after injection. The eyes of another group were evaluated with preoperative and postoperative indirect ophthalmoscopy, electroretinography, and histologic examination. No retinal toxicity was found.

Liposome-Encapsulated 5-Fluorouracil: A New Approach to PVR

Proliferative vitreoretinopathy (PVR) is one of the leading causes of failure in retinal reattachment surgery. This process involves the formation of membranes on the inner and outer retinal surfaces, as well as in the vitreous, and is followed by proliferation and eventual contraction with resultant retinal traction and finally retinal detachment. The main cellular components of these membranes include retinal pigment epithelial cells, glial cells, and fibroblasts.